ALT Figure 5. ror1/2 and ryk are co-expressed dynamically with fzd1/2/7 and fzd5/8. (A) ror1/2 is co-expressed with both frizzled (fzd) receptors during the mid-blastula stage. ror1/2 is downregulated in the ventral ectoderm during mesenchyme blastula and gastrula stages, where fzd1/2/7 is upregulated and co-expressed with fzd5/8 only in the mesoderm cells. (B) ryk is also co-expressed with both fzd receptors but shows increased expression in the posterior pole of the embryo during the mid-blastula stage. At the mesenchyme blastula stage, ryk maintains co-expression with both fzd receptors, but by the gastrula stage, it is excluded from embryonic territories overlapping with fzd1/2/7 but maintains co-expression with fzd5/8 in the anterior neuroectoderm. DAPI, 4′,6-diamidino-2-phenylindole.