Joined November 2016
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- Following 1,145
- Followers 1,057
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267 Photos and videos
Arsene Mekinian retweeted
Apr 24
En ce 24 avril, la République commémore le génocide des Arméniens de 1915 et s'incline devant la mémoire des victimes.
C'est une occasion de se souvenir, de transmettre et de souligner le lien indissoluble qui unit la France à l'Arménie et les Français aux Arméniens.
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Arsene Mekinian retweeted
Apr 11
Can HCQ delay or prevent onset of rheumatoid arthritis? The StopRA trial found HCQ did not prevent development of clinical RA at 36 months among at-risk individuals
Read the April Arthritis & Rheumatology Editor's Pick:
doi.org/10.1002/art.43366
ALT April 2026 Arthritis & Rheumatology editor's pick banner
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Bardy R, Detournay E, Guedon AF, Mekinian A, Morard M, Kraeber-Bodéré F, Jamet B, Besson FL, Espitia O. Prognostic Value of Cranial Arteries Involvement on 18F-FDG PET/CT at Giant Cell Arteritis Diagnosis in a Multicenter Cohort. Clin Nucl Med. 2026 Mar 24. doi: 10.1097/
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Arsene Mekinian retweeted
Apr 6
Whole-exome seq study of 174 patients with SLE treated with glucocorticoids identified heterozygous variants in ANK1 and EPB41, associated with higher risk of steroid-induced osteonecrosis of the femoral head
Arthritis & Rheumatology
doi.org/10.1002/art.70153
ALT Diagram showing ANK1 and EPB41 as susceptible genes for SONFH. The effects of ANK1 and EPB41 variants lie on a phenotypic spectrum, ranging from nondamaging, asymptomatic on one end of the spectrum, to severe clinical hemolytic anemia on the other end of the spectrum. The variants identified in our study represent a milder intermediate phenotype. The carriers of a single altered copy (heterozygous state) demonstrate increased osmotic fragility and reduced red blood cell deformability compared to non-carriers, which does not produce hemolysis or anemia but represents a subclinical phenotype. However, this partial impairment appears sufficient to predispose individuals to the development of osteonecrosis in the presence of the second hit (i.e., corticosteroid exposure).
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Arsene Mekinian retweeted
New content online: Fertility, pregnancy and lactation in women with systemic lupus erythematosus dlvr.it/TRw43w
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Arsene Mekinian retweeted
POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes) syndrome is a rare multisystem disorder where early identification is essential for better long term outcomes. Yet it is often misdiagnosed. Gonçalves et al review the condition here:
jnnp.bmj.com/content/early/2…
And this is a related editorial: jnnp.bmj.com/content/early/2…
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Arsene Mekinian retweeted
Mar 30
Phase 3b TOGETHER-PsA trial of ixekizumab tirzepatide in comorbid overweight or obese adults with PsA showed clinically meaningful improvement of psoriatic disease, physical function, weight reduction, & quality-of-life, with no new safety concerns
A&R
doi.org/10.1002/art.70134
ALT Ixekizumab with Tirzepatide Achieved Greater Disease Control than Ixekizumab Alone in Adults with Psoriatic Arthritis and Overweight or Obesity: Results from the TOGETHER-PsA Trial. A graphical abstract
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Presented at #ISNWCN:
Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy. Full phase 3 APPLAUSE-IgAN trial results: nejm.org/doi/full/10.1056/NE…
@ISNWCN
ALT A figure showing the change from baseline in the estimated glomerular filtration rate (eGFR) for iptacopan and placebo as the estimated slope for the primary end point (primary analysis).
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Arsene Mekinian retweeted
Mar 28
At least 12 million babies have been born thanks to in vitro fertilisation (IVF), but how did we reach this miraculous milestone?
In the 1950s, British scientist Robert Edwards began his research on the biology of fertilisation and soon realised that fertilisation outside the body could be used to treat infertility. He discovered important principles for human fertilisation including how human eggs mature, and first succeeded in accomplishing fertilisation of human egg cells in test tubes – or more precisely, cell culture dishes – in 1969.
Despite his breakthrough, there was a problem that a fertilised egg could not develop beyond a single cell division. Edwards suspected that eggs that had matured in the ovaries before removal would function better, and looked for possible ways to obtain such eggs in a safe way.
His collaboration with gynaecologist Patrick Steptoe enabled IVF to grow from experimental to practical medicine. Together, they used laparoscopy – a technique pioneered by Steptoe – to remove eggs and put them in a cell culture before adding sperm, which enabled the fertilised eggs to form into early embryos.
On 25 July, 1978, Louise Brown, the world’s first “test tube baby” was born. IVF treatment began the previous year when a fertilised egg was developed into an embryo and returned to her mother, Lesley Brown. Louise’s birth marked a major milestone in reproductive medicine and gave hope to millions of people struggling with infertility.
Edwards and Steptoe established the Bourn Hall Clinic in Cambridge – the world’s first centre for IVF therapy – and refined their technology. By 1986, 1,000 children had already been born following IVF at the clinic.
Today, IVF is a sophisticated and widely accessible fertility treatment option that has allowed millions to experience the joy of parenthood.
Learn more about Robert Edwards: nobelprize.org/prizes/medici…
Photo: iLexx via Getty Images.
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Arsene Mekinian retweeted
2025 update of EULAR recommendations for the management of Behçet’s syndrome
⏩Mucocutaneous and joint involvement: Colchicine is first-line; apremilast or TNFαi for refractory cases.
⏩Organ-threatening: GC IS, with prompt use of monoclonal TNF
ard.eular.org/article/S0003-…
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Presented at #AAD2026:
In the VALOR trial of brepocitinib in adults with dermatomyositis, the 30-mg dose (but not the 15-mg dose) led to greater improvement on a composite myositis index at 52 weeks than placebo. Serious infections were more frequent with the 30-mg dose. Full trial results: nejm.org/doi/full/10.1056/NE…
@AADmember
ALT A figure showing the Total Improvement Score among the patients with treatment-resistant dermatomyositis who received 30 mg of brepocitinib, 15 mg of brepocitinib, or placebo daily for 52 weeks.
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Images in Clinical Medicine: Massive Intravascular Hemolysis from 𝘊𝘭𝘰𝘴𝘵𝘳𝘪𝘥𝘪𝘶𝘮 𝘱𝘦𝘳𝘧𝘳𝘪𝘯𝘨𝘦𝘯𝘴 Bacteremia nejm.org/doi/full/10.1056/NE…
#EmergencyMedicine #IDTwitter
ALT Panel A: Photo of the specimen. Panels B and C: A postmortem review of a peripheral-blood smear showing numerous dehemoglobinized red cells with intracellular and extracellular bacilli. Panel D: Cardiac tissue showing numerous gram-positive and gram-negative bacilli, with gram-positive organisms predominating.
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Arsene Mekinian retweeted
Rare. Un témoignage et quelques images sur l'#Artsakh #HautKarabakh depuis son nettoyage ethnique par l'Azerbaïdjan en 2020-2023. Un pays désert, sans vie, sans âme, où toute trace de présence des #Armeniens est effacée. Les 15 derniers #Armeniens sont partis en février 2026.
Mar 19
Korean Blogger Shows #Artsakh Under Azerbaijani Occupation: Empty Cities, Tourist Restrictions, and Erasure of Centuries-Old Armenian Identity
A South Korean travel blogger has published a rare video of his recent trip to Artsakh, providing one of the few internal perspectives on the region following its transition to #Azerbaijani control and the ethnic cleansing of the #Armenian population in 2023.
Traveling through Shushi, Askeran, and Stepanakert, YoungMin Skies captured empty streets, destroyed sites, and what he described as a systemic attempt to erase #Armenian traces and redefine the identity of the occupied region.
The trip to #Artsakh took place as part of an organized group; according to the blogger, obtaining individual permission proved virtually impossible. Tourists were not allowed to leave the minibus, and access to sites was strictly controlled, effectively shaping the narrative presented to them.
The blogger also drew personal parallels between his family's history in North Korea and the Armenians deprived of access to their ancestral lands, noting a similar experience of loss and forced displacement from one's homeland.
According to him, traveling through the practically deserted territory left an oppressive impression. Upon entering Stepanakert, the former capital, his initial emotions were: "Tragedy, sadness. Everywhere you look, there are empty houses."
The blogger emphasized the scale of desolation and destruction in the city. Many Armenian sites have been destroyed, rebuilt, or repurposed. However, the iconic "We Are Our Mountains" monument, also known as "Tatik-Papik," remains untouched. In his view, this is a political decision: despite attempts to erase #Armenian heritage, the monument has been left as a controlled symbol, demonstrating that the authorities decide which elements of the past to preserve.
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Arsene Mekinian retweeted
Mar 13
NEJM: Obinutuzumab in Active Systemic Lupus Erythematosus
A phase 3 trial of obinutuzumab, an anti-CD20 monoclonal antibody, showed potent B-cell depletion and clinical efficacy active systemic lupus erythematosus without evidence of nephritis.
buff.ly/1vYVMAS
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Arsene Mekinian retweeted
Mar 13
#Antiphospholipid antibodies and #cardiovascular #thrombosis, now in @NatRevCardiol 👇:
dlvr.it/TRQCr6
Systematic summary across various conditions. In some cases, we challenge the old conventional thinking...
Truly multidisciplinary, led by our 🌟fellow @SinaRsh
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Arsene Mekinian retweeted
Mar 11
Systematic review and meta-analysis estimated pooled prevalence of HCQ-retinopathy was 5% between 2008 to 2023, and cumulative incidence rose over time. Patients receiving HCQ >5 mg/kg/day of actual body weight had 4-fold higher risk
AC&R
doi.org/10.1002/acr.80033
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Arsene Mekinian retweeted
Mar 11
CAR-T cells targeting CD19 for the treatment of ANCA vasculitis
doi.org/10.1093/ckj/sfaf290
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Arsene Mekinian retweeted
Mar 11
Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease - Deboo - Arthritis Care & Research - Wiley Online Library #sjogrens #sjogrensfoundation
acrjournals.onlinelibrary.wi…
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Correspondence: Blinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome nejm.org/doi/full/10.1056/NE…
#Hematology #Immunology
ALT A figure showing treatment with CD19-directed bispecific T-cell engager in resistant immune thrombocytopenia and antiphospholipid syndrome.
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