Biology doesn’t change at the border. Autism risk does not depend on the flag printed on a vaccine schedule. What matters is exposure biology: •antigen load •timing •cumulative dose •developmental windows Those are measured by large birth-cohort and registry studies that follow children from birth using medical records — the right design for outcomes diagnosed years later. Arguing about schedule labels is a distraction. Causation lives in mechanisms, dose–response, and replication — not semantics.

This beautifully sweet guy is our people, @Cvanderpunk2. 🥹🥹🥹 💗🎨💗

It is interesting to me that many people assume dementia “runs in the family,” when most dementia cases are actually sporadic rather than directly inherited. Family history can increase risk, but truly hereditary forms are relatively rare. #Alzheimer, for example, is the most common cause of dementia, accounting for an estimated 60–80% of cases. Yet only about 5% of Alzheimer’s cases are caused by inherited genetic mutations, and these forms usually begin at a younger age. Most cases develop from a combination of aging, vascular health, lifestyle and environmental exposures, including to pathogens. We know that conditions such as high blood pressure, diabetes, high cholesterol, obesity, and heart disease damage blood vessels and increase dementia risk because the brain depends heavily on healthy circulation. These conditions can disrupt the blood–brain barrier (BBB), increasing its permeability and allowing inflammatory molecules and other harmful substances to affect brain tissue. Physical inactivity and poor sleep also play an important role. Regular exercise supports blood flow, reduces inflammation, and improves insulin sensitivity, while chronic sleep disruption is associated with increased accumulation of abnormal proteins linked to Alzheimer such as tau (NFTs) and amyloid (AB). What receives less attention is the growing evidence that some infections may also contribute to dementia risk through several possible mechanisms. Can be direct infection of the brain cells (seen in HIV, #Covid, herpesviruses and others) or by chronic immune activation and inflammation, which damage blood vessels and contribute to vascular impairment. There is also growing research linking reactivation of dormant viruses after an infection, and interactions between infections contributing to dementia in some individuals. Overall, chronic systemic inflammation appears harmful to brain health. Repeated severe infections or persistent inflammatory states may contribute through vascular damage and prolonged immune activation. There is still a great deal we do not understand about dementia and neurodegenerative diseases, which is one reason why truly effective treatments are still not available.

Amazing

Best advice I have had all day.

Don’t let anyone ruin your day. You’re an adult, do it yourself….

Happy Barack Obama appreciation day #ObamaDayJune14 #smokefléét

Trump's reflecting pool is a cesspool

Happy Barack Obama appreciation day #ObamaDayJune14 #smokefléét

Why One Nation's 'solution' to housing issues is the most expensive possible way to save $4,700. Fiscal blundering aside, it's a bad, bad idea, when you consider that most Australians want to 'age in place' rather than be booted out of their family home and go and live in a nursing home. Not going to win them any votes. Sorry, @PaulineHansonOz. linkedin.com/pulse/dear-one-…

Happy Barack Obama appreciation day #ObamaDayJune14 #smokefléét

In Brazil, a 21-year old woman thought she was going base-jumping, but instead she was tossed off a bridge by employees who forgot to attach her to ropes or a safety harness. She fell 40M to her death. People are not okay.

Happy Barack Obama appreciation day #ObamaDayJune14 #smokefléét

The Kennedy Center is BACKKKKKKKKKKKKKK!

Our warriors have achieved good results in applying long-range sanctions against important facilities on the territory of Russia and in the temporarily occupied territories of Ukraine. More than 700 kilometers from our state border, in Russia’s Yaroslavl region, SSU warriors struck an oil facility that was important for the reserves of the aggressor state. Warriors of our army reached their targets in Russia’s Tula region – specifically, the Azot plant, whose operations are critical to explosives production capabilities. Air traffic restrictions were imposed at six Russian airports, and overall, since yesterday evening, 28 regions of Russia have been under air raid alerts. There were also hits on the occupier’s military logistics in the temporarily occupied territory of Ukraine. Ukraine is carrying out its plan of long-range sanctions against Russia and the assigned tasks regarding mid-range strikes in response to Russia’s refusal to end this war. We have offered the Russian leadership every possible format for negotiations – and the only response was continued aggression and attempts to expand it. It stands to reason that the war is coming back to where it came from. Ukraine needs peace. Glory to Ukraine!

Just broke two of my old Queen records. Now I want to break three.

The work crew is really groovin’ as Trump’s name is ripped off the Kennedy Center. 😂 “Young man, pick yourself off the ground” … peak YMCA celebration vibes. 🎶 America is healing one scaffold dance at a time! 🕺 #YMCA #KennedyCenter

A blind Ukrainian veteran has made 1,000 pottery pieces — plates, mugs, candle holders — but has never seen a single one. Ivan Shostak lost his eyesight in Bakhmut after a Russian blast. “I learned you can live in total darkness,” he says, AP. 1/

So Zelensky desecrated the White House by not wearing a suit but this is ok?????

Done. Mesa Amphitheatre. Phoenix, Arizona. Proud of my gang. 42°outdoor set and didn’t drop a song. Kudos too to that undeterred, intrepid audience. Stirling attendance! In your service. :-)

Pure hell in Vasylkivka, Dnipropetrovsk region. russians dropped 12 KAB glide bombs on a market. A fucking market. A Saturday morning — people just coming out to sell what they have. Just a regular, everyday market… gone in an instant.