Microbiologist at @polybioRF: studying how persistent pathogens drive inflammaging, mitochondrial dysfunction & cognitive decline #longcovid #lyme #alzheimers
Joined September 2017
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8 Dec 2024
It was great to do this podcast. Persistent #viruses - and many bacteria, fungi and even parasite pathogens - directly hijack our #mitochondria. They can hack and distort human gene signaling that controls senescence & inflammaging. This knowledge is huge for longevity treatments
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Check out these talk summaries from our recent PolyBio Symposium👇
Highlights include that four groups — Tim Henrich (UCSF), Marcus Buggert (Karolinska), Nicolas Huot (Institut Pasteur), and Esen Sefik (Yale) — presented different lines of evidence (human gut biopsies, non-human primate models, humanized mice) all pointing to the same conclusion: SARS-CoV-2 persists in #LongCovid gut tissue and adjacent lymphoid structures, and that persistence drives ongoing immune dysregulation.
Jun 1
Written summaries of PolyBio’s Spring symposium presentations are available now! Check out shortened, simplified summaries, or full technical explanations of your favourite research projects.
Interactive resource: 2026-spring-symposium-polybi…
#longcovidresearch #mecfsresearch #lymeresearch
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6/ Researchers reported increased fibrin-amyloid microclots, elevated neutrophil activation and NET formation, platelet-monocyte aggregates, altered platelet serotonin, SARS-CoV-2 RNA detected in platelets, and evidence that Spike immune complexes can directly drive vascular injury.
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7/ Additional work is investigating whether SARS-CoV-2 persists within vascular tissue itself, potentially sustaining chronic inflammation and cardiovascular risk.
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May 24
Hey! If you’re in Boston check out my talk this Tues at @LongevityGL Aging Code Summit
I’ll overview mechanisms by which persistent infections can accelerate human aging processes. This includes how viruses, parasites & other pathogens directly hijack our mitochondrial activity
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Amy Proal, PhD retweeted
May 22
Follow along with the #polybiospringsymposium2026 in this thread👇🏻
11:00 am ET—Dr. Amy Proal kicked off this Spring symposium with an overview of PolyBio’s new commercialization network that will help translate Long COVID biomarkers from the lab & therapies from coordinated clinical trials into useful tools in the clinic. She also discussed how this commercialization infrastructure can be applied to other IACIs.
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May 21
Yes I am excited! Some of the updates on our Long COVID and related chronic illness projects will be truly interesting.
See you tomorrow!
PS: There is a Q&A at the end of each hour so get your questions ready
May 9
Excited for PolyBio’s upcoming Spring symposium on Friday, May 22? Here’s the full program of presenters you’ll hear from!
From novel platforms of detection for SARS-CoV-2 & herpesviruses implicated in Long COVID, to updates on clinical trials & the Long COVID Cure Initiative, this scientific symposium has a presentation lineup you won’t want to miss. 🧵
polybio.org/2026-spring-symp…
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Apr 27
This is an incredible $10M donation to our PolyBio Long COVID Cure Initiative (LCCI) Program. Funds are from the Park-Pagliuca Fund: a philanthropic collaboration between the families of Todd Park & Steve Pagliuca, each of whom have family members impacted by Long COVID
Apr 27
Breaking: Park-Pagliuca Fund Donates $10 Million to PolyBio Long COVID Cure Initiative
PolyBio Research Foundation today announced a $10M donation to support the Long COVID Cure Initiative (LCCI), a program designed to deliver treatments to millions of Long COVID patients by translating key academic findings into real-world diagnostic tests, faster and more targeted clinical trials, and accessible, patient-ready therapies.
prnewswire.com/news-releases…
ALT A man with reddish brown hair wears a blue surgical mask and lab goggles and looks under a lab hood to pipette liquid.
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Apr 27
12/ This is the systems-level approach that transformed HIV from fatal to manageable - and it's now being built for Long COVID
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Apr 27
So let's go! We've put out a lot of papers and changed the field, but people are still sick. Let's get all of these scientific advances out of academic labs and into patients' lives.
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