Metabolic #BariatricSurgery in youth with #diabetes and obesity is associated with improved kidney outcomes. However, the mechanisms underlying kidney protection is unclear. doi.org/10.1172/JCI198545 Here, Abhijit S Naik @minimalchange & team @UMichMedSchool explore structural and transcriptomic changes before and after vertical sleeve gastrectomy in kidneys of obese youth with diabetes, revealing targets for non-surgical interventions against #KidneyDisease.

JCI Insight - The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure insight.jci.org/articles/vie…

We propose GH-IGF1 mediated signaling as a potential risk factor for long term kidney allograft survival. medrxiv.org/content/10.1101/…

Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy biorxiv.org/content/10.1101/…

In the Literature commentary by @minimalchange and Frank C. Brosius: Cannabinoid Signaling in the Diabetic Proximal Tubule: Of Mice and Men buff.ly/3CcpKT8 (FREE)

kidney-international.org/art… Identification of glomerular cell type stress after kidney transplant at a single cell resolution. We observed significant reduction in nephrin and key integrin (ITGA3) both at an mRNA and protein level. Thanks KPMP, HCA, NIDDK @MiKTMC @UMichKidney

rdcu.be/cyIy8 The timing of ACE inhibition in relation to uni-nephrectomy has significant impact on hypertrophic stress associated single kidney outcomes. Ramifications for kidney transplantation and live donors? @UMichKidney @UMIntMed

Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan onlinelibrary.wiley.com/doi/… Our heuristic approach in testing the idea that podocyte injury and detachment continue across lifespan of allograft. @UMichKidney

SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease kidney-international.org/art… . @MiKTMC @UMichKidney @umichmedicine @Berthiercc @OlgaTroyanskaya .

#GraphicalAbstract doi.org/10.1016/j.kint.2020.… @minimalchange @UMichKidney

I think it is a very important cause of late kidney allograft failure! #ATC2020Virtual

New from a fantastic group @MiKTMC /Princeton as preprint that leverages the power of scRNAseq to demonstrate how cells in pathologic environments (e.g. diabetes) have their cellular machinery primed for viral (SARS-CoV-2) entry. medrxiv.org/content/10.1101/…

See our paper in KI that uses nephron segment specific urine mRNAs to explore how systemic blood pressure might initiate and drive subclinical glomerular injury and affects glomerulus >> tubular compartments. sciencedirect.com/science/ar… @UMichKidney @UMIntMed @MiKTMC @Kidney_Int

1/7 We just published a new single-cell transcriptomics study in @JCI_Insight using @KPMP, #NEPTUNE, and #ERCB data. insight.jci.org/articles/vie… Check out the single-cell data in our new tool: nephrocell.miktmc.org

See our article on impact of donor BMI on kidney allograft outcomes and an accompanying editorial @UMichKidney

University of Michigan spends record $1.62 billion on research in 2019 mlive.com/news/ann-arbor/201…

Dustin our star resident (University of Michigan) describing his work at Kidney week to KIDNEY STARS @UMichKidney @MiKTMC

Publish houses of brick, not mansions of straw : Nature News & Comment nature.com/news/publish-hous… via @NatureNews

Having a great time at #KPMP. So much amazing stuff going on here. Indebted to my mentors.