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18 Oct 2023
Towards a biologically annotated brain connectome | doi.org/10.1038/s41583-023-0…
How do we integrate local biological annotations with connectome wiring?
@VinceBazz @JustineYHansen lay out how to build and analyze annotated connectomes @NatRevNeurosci ⤵️
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Bratislav Misic retweeted
May 27
Our latest work is now out in @NatureNeuro 🎉
Using brain scans in 🐭mice and humans 👨 we show that variable patterns of brain activity in #autism reflect distinct underlying biological mechanisms!
👉nature.com/articles/s41593-0…
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Bratislav Misic retweeted
May 19
🔥Our opinion piece with @DuncanAstle on “why we might be better off accepting and embracing the fact that the brain’s connectivity profile is in no way optimal” is now out on @TrendsCognSci. There, we discuss implications for Neuro-AI and psychopathology.
cell.com/trends/cognitive-sc…
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Bratislav Misic retweeted
May 21
In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests.
Here's our new preprint doi.org/10.64898/2026.05.17.… led by @tianchuzeng @kkli20111 @ZShaoshi @ten_photos 1/N
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Bratislav Misic retweeted
May 21
MULTIORGAN networks across the human body over the course of aging & disease
A rapidly developing field shaped by @yetianmed & @JunhaoWen
Check out our Perspective in @NatureAging
rdcu.be/fjMAz
Concepts, priorities & recommendations to get started in the field
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Bratislav Misic retweeted
May 12
Disease biology is heterogeneous, but most research reduces it to group means
NEW WORK characterizing HETEROGENEITY in BRAIN and BIOCHEMICAL biomarkers across >1/2 million people & >30 disorders:
nature.com/articles/s41467-0…
Check out the online resource:
tinyurl.com/bdecwsnb
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Bratislav Misic retweeted
🔬 New preprint: We introduce NEOFC—a framework linking brain connectivity to neurotransmitter systems. Reveals robust neurochemical signatures, strong noradrenergic effects, and sensitivity to drugs & psychosis.
📄 biorxiv.org/content/10.64898…
#Neuroscience #Neuroimaging
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Bratislav Misic retweeted
Apr 14
Polysynaptic routes in the WHITE MATTER CONNECTOME reveal neuroanatomical basis for TMS therapy
Shorter anatomical routes between stimulation site & deep brain target predict superior response
A step fwd for Network Neuroscience!
Out now: @NatureNeuro
rdcu.be/fdl8x
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Bratislav Misic retweeted
Mar 31
The lab's first published paper is here and I could not be more excited!! If you're interested in proteomics, AI or both, it could be an interesting read. Congrats @anlijuncn for a great piece of work, and big shout out to our collaborators at @_neuroproteome and @biofinder_study
Mar 31
[1/7] Our work is now out in @NatureMedicine nature.com/articles/s41591-0… We developed a state-of-the-art AI-proteomics model for diagnosing multiple neurodegenerative diseases from blood plasma.
See previous thread for a summary – but some updates in the published version described below. ProtAIDe-Dx now outperformed both classic machine learning models and even foundation models like TabPFN!
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Bratislav Misic retweeted
Mar 27
Neuropeptides act as diverse signaling molecules that regulate both basic bodily functions and complex cognitive processes within the human brain.
doi.org/10.1038/s41593-026-0…
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Bratislav Misic retweeted
Mar 25
Mapping connectomes in disease?
Check out our article on clinical connectomics in @NeuroCellPress
- Tractography behavior in disease
- How to measure connectivity
- How pathology impacts each stage of connectome mapping
- Multiscale connectomics
cell.com/neuron/fulltext/S08…
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Bratislav Misic retweeted
Mar 18
Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function
#neuroscience
Mar 17
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s41593-026-0…
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@ericg_ceballos curates an atlas of neuropeptide receptors and relates it to brain function @NatureNeuro 🧩 🧠 ⤵️
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Bratislav Misic retweeted
Mar 18
Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function
#neuroscience
Mar 17
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s41593-026-0…
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@ericg_ceballos curates an atlas of neuropeptide receptors and relates it to brain function @NatureNeuro 🧩 🧠 ⤵️
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Mar 17
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s41593-026-0…
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@ericg_ceballos curates an atlas of neuropeptide receptors and relates it to brain function @NatureNeuro 🧩 🧠 ⤵️
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Mar 17
8⃣ Finally, we replicate all findings using alternative processing and analytical choices.
We also conduct multiple sanity check/domain knowledge experiments, including detailed analysis of peptides related to feeding, sexual dimorphism and vasomodulation.
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Mar 17
9⃣ Collectively, these results show that the neuropeptide receptors are highly organized across the human brain and closely intertwined with multiple features of brain structure and function.
paper: rdcu.be/e8zTZ
data code: github.com/netneurolab/cebal…
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