Stochastic Biology Group: using maths, stats, and experiments to learn about biology and disease. We love organelles and oDNA, evolution, noise, and inference.
Joined January 2013
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374 Photos and videos
Iain Johnston retweeted
Jun 10
The majority of axonal mitochondria in mammalian neurons lack mitochondrial DNA and do not produce ATP biorxiv.org/content/10.1101/…
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Jun 9
Excited to share a new preprint!
Lots of evolutionary processes, from AMR to cancer, involve biology acquiring features (drug resistances, mutations, etc). These are sometimes called "accumulation pathways", an instance of discrete character evolution. 1/
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Jun 9
This sets up for a version of the Mk model that scales linearly in observations instead of exponentially in features, and can handle interactions, reversibility, coupling, missing data, and more. We think this could be quite a generally useful advance! 4/
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Jun 9
We apply it to the evolution of drug resistance in TB and Klebsiella, and show its interoperability with other problems. The link is
biorxiv.org/content/10.64898…
... would love to hear thoughts!
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May 17
It's 17th May and Norway is beautiful. Gratulerer med dagen! 🇳🇴
(lots going on in arXiv and other science news, but that's for later)
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David Attenborough, 'the voice for nature,' turns 100 reut.rs/48EFrlX reut.rs/48EFrlX
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Apr 28
The dish occupies a cubic metre and the bacteria are generating 10kW of heat. They can clearly access nutrients beyond currently understood biochem (and physics). The wobbly, hot mass has noticeably expanded while I've been typing. An alarm sounds. The sky darkens
#bionumbers
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Apr 2
Mitochondrial evolution special issue of Phil Trans now out! royalsocietypublishing.org/r…
Excited to be part of this, with some new perspectives on mtDNA segregation from our group royalsocietypublishing.org/r… and brilliant content from colleagues worldwide! Pics from current location 🇳🇴
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Mar 30
Oldest back from school today with an Easter graph theory challenge! "It's sort of a puzzle -- which bunnies can see which others, and the flower?"
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Iain Johnston retweeted
Mar 24
Blimey.
MitoTracker transfers from astrocytes to neurons independently of mitochondria: Cell Reports Methods cell.com/cell-reports-method…
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Mar 20
Celebrating (i) spring; (ii) grant award; (iii) first butterfly of the year (not pictured); (iv) forthcoming cool science! Best wishes to all!
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Iain Johnston retweeted
New OA Article: "High-frequency biparental inheritance of plant mitochondria upon chilling stress and loss of a genome-degrading nuclease" rdcu.be/e6GEA
Maternal inheritance of mitochondria breaks down in cold when a mitochondrial DNA degrading nuclease is defective.
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Iain Johnston retweeted
One of the most fascinating perspectives ever.
A symbiotic origin of the ribosome?
academic.oup.com/pnasnexus/a…
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Iain Johnston retweeted
Feb 12
If you love the organelles that power life, come to @GordonConf Mito & Chloroplasts July 19-24, Maine. Please RT.
This conference (rich tradition!) will span the evolution, metabolism, and synthetic biology of these organelles.
Many oral/poster slots:
tinyurl.com/5n6upfxr
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