Max Delbrück Center for Molecular Medicine, Berlin and Sanford Consortium for Regenerative Medicine, San Diego
Joined March 2017
- Tweets 566
- Following 119
- Followers 1,691
- Likes 889
106 Photos and videos
Maike Sander & Lab retweeted
A promising drug target for regenerating functional β-cell mass in diabetes!
@WorthamLab, @msanderlab & team @UCSanDiego discover the deacetylase SIRT2 restrains proliferation of pancreatic β-cells in a glucose-dependent manner: jci.org/articles/view/187020
The image shows labeling of SIRT2 (red), insulin (green), and nuclei staining (blue) in mouse pancreatic islet sections.
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21 Aug 2024
We are recruiting a postdoctoral researcher @MDC_Berlin
iPSC islet cell models
High throughput screens in iPSC models
Organ-on-a-chip
Genomics and computation
Please RT! DM if you want to learn more.
mdc-berlin.de/career/jobs/po…
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23 Apr 2024
I look forward to an exchange of science with colleagues at Heidelberg University. It’s been a while - I graduated from Heidelberg University in 1994.
23 Apr 2024
Join us for a talk by Maike Sander on "Understanding and Treating Diabetes with Islet Stem Cell Models" April 29, 2024 16:00, BioQuant, SR41
@UniHeidelberg @uniklinik_hd @msanderlab @MDC_Berlin
Please RT
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28 Feb 2024
Very honored to join the @ChariteBerlin faculty. I look forward to the work ahead with wonderful colleagues.
28 Feb 2024
On March 1, our Scientific Director Maike Sander (@msanderlab) will take up her appointment as professor for "Pancreatic Organoid Research and Disease Modeling" at @ChariteBerlin. Dean Joachim Spranger presented her with the certificate. Congratulations!
mdc-berlin.de/sander
ALT Maike Sander and Joachim Spranger with the certificate
ALT Maike Sander and Joachim Spranger with the certificate
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28 Feb 2024
Congratulations to @WorthamLab and the many other contributors. The study identifies Sirtuin-2 as a glucose-dependent regulator of beta cell proliferation.
28 Feb 2024
I’m excited to share our discovery of a novel regulator of adaptive beta cell proliferation–the protein deacetylase SIRT2–from work in @msanderlab together with many key contributors including Bastian Ramms, Chun Zeng, Jackie Benthuysen, and @someshtweet biorxiv.org/content/10.1101/…
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Thrilled to announce that registration and abstract submission for European Islet Study Group meeting in Helsinki, Finland, 18-20 June 2024 is NOW OPEN! helsinki.fi/en/conferences/e…
🚨Early-bird registration is March 15th, limited seats available🚨
Please RT ;)
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4 Jan 2024
Very much look forward to my upcoming visit to @CRGenomica - to learn about the outstanding science and to visit our @EULIFE_news partner institution. Of course, also to experience beautiful Barcelona.
4 Jan 2024
📣 PRBB-CRG conference
📋 Insights into diabetes from stem cell islet organoids and single-cell genomics
🗣️ Maike Sander @msanderlab
📆 Jan 12
⏰ 12:00 CET
🤝Hosted by Jorge Ferrer, CRG
📍Marie Curie room #PRBB
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25 May 2023
Out today @NatureGenet our work on mechanisms of beta cell dysfunctions in type 2 diabetes (T2D) combining single-cell genomics and Patch-seq. Congratulations to @GaoweiW @JoshChiou, Chun Zeng. Big thanks to @kjgaulton @seb11pr @bcellorg, F Kandeel, S Kim.
rdcu.be/dcZQs
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25 May 2023
We identified two distinct beta cell subtypes that exhibit an abundance shift in T2D. T2D risk variants are enriched in subtype-defining accessible chromatin. Both subtypes exhibit functional impairment in T2D, likely induced by the T2D-associated metabolic environment.
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6 May 2023
The @MDC_Berlin is seeking a Head of Innovation & Commercialization. An opportunity to shape a modern innovation office.
Please RT!
DM me with any questions.
19 Apr 2023
#NowHiring: join the #mdcBerlin as "Head of Innovation & Commercialization" and advise our scientists in creating industry alliances or spin-off companies.
📢 permanent, full-time position with great compensation and benefits‼️
𝗔𝗣𝗣𝗟𝗬: mdc-berlin.de/career/jobs/he… #JobOpening
ALT Graphic for a job opening at the Max Delbrück Center: Head of Innovation and Commercialization (Technology Transfer) (f/m/d). Apply by May 31, 2023. Located on the Campus Berlin-Buch.
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Maike Sander & Lab retweeted
23 Mar 2023
Retweeting our call for senior scientist or postdoc at the Max Delbrueck Center in Berlin with correct link to application website.
1. iPSC-islet organoids
2. Metabolomics
3. Single-cell biology and screens
mdc-berlin.de/career/jobs/se…
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Maike Sander & Lab retweeted
18 Apr 2023
It was a pleasant surprise to see the commentary on our recent JCI paper by @powersac_TN and Kristie Aamodt who provide an apt metaphor for the regulatory layers of beta cell function jci.org/articles/view/169718. Thanks for highlighting! Original article here: jci.org/articles/view/165208
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11 Apr 2023
We are thrilled to share our single-cell genomics analysis of stem cell islet differentiation in Dev Cell:
authors.elsevier.com/a/1gua-…
Congratulations to Han and Gaowei, who led this study, and thank you to collaborators @LabSpagnoli @kjgaulton @powersac_TN 1/2
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11 Apr 2023
We identified a pre-β-cell population in the fetal pancreas that produces serotonin under the control of the transcription factor CDX2. This transient pre-β-cell population resembles enterochromaffin cells in stem cell islets, suggesting these are not pancreas-aberrant. 2/2
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Maike Sander & Lab retweeted
22 Mar 2023
Join @msanderlab as a #postdoc! It aims to understand & reverse pancreatic beta cell dysfunction in #diabetes. It employs #hPSC-based models and interrogates these models combining functional & #singlecell based genomic assays. #postdocjobs
👉mdc-berlin.de/career/jobs/se…
ALT Senior research scientist / postdoc (F/M/D) Apply by April 30, 2023 Sander Lab
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21 Mar 2023
Join our team @MDC_Berlin as senior scientist or postdoc!
1. iPSC-islet organoids
2. Metabolomics
3. Single-cell biology and screens
recruitingapp-5471.de.umanti…
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Maike Sander & Lab retweeted
13 Mar 2023
Helmholtz delegation visit to Sydney. Wonderful discussions with a perfect view of Sydney harbor. @KatrinJM @msanderlab
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23 Feb 2023
We’re thrilled that our work on epigenomic regulation of adaptive insulin secretion is out @jclinicalinvest! A massive effort led by @WorthamLab, who will continue this research as faculty at UCSD. Thanks to @kjgaulton, @HuisingLab, Christian Metallo. 1/3
jci.org/articles/view/165208
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23 Feb 2023
We found that feeding increases H3K27 acetylation in pancreatic islets, and that the chromatin modifying enzyme Lsd1 mediates deacetylation of these sites between meals. Experimental manipulations that prevent resetting of feeding-induced changes cause insulin hypersecretion. 2/3
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23 Feb 2023
Sites of LSD1 recruitment in human islets are enriched for T2D-associated variants, revealing a potential mechanism whereby genetic background influences adaptive insulin secretion. Stay tuned to @WorthamLab who will continue this exciting research. Much more to come! 3/3
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