Developmental and stem cell biology lab. Understanding the control of cell identity and plasticity and how to use it in regenerative medecine @KCLstemcells
Joined May 2019
- Tweets 995
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- Followers 1,109
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36 Photos and videos
Pinned Tweet
26 Aug 2021
So excited to share our new paper today @Nature
Truly interdisciplinary study: #computational modelling, #lineagetracing and #scRNASeq uncovers sustained plasticity in hepato-pancreato-biliary development (1/2)
disq.us/t/40i2bhl
@LabSpagnoli @KCLstemcells @kingsmedicine
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May 19
📣 New PRBB-CRG conference
📋 Mapping progenitor niche dynamics for regulation of cell fate
🗣️ Francesca Spagnoli (@LabSpagnoli) - @KCLstemcells
📆 May 22 - ⏰ 12:00
hosted by: @1jorgeferrer - @CRGenomica
📍 #PRBB Maria Skłodowska-Curie room
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May 16
🎇Great fun writing this #review with
#AlejoTorresCano, highly talented postdoc in @LabSpagnoli
🤔reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity
@wellcometrust @kingsmedicine @BreakthroughT1D @DUK_research
New online! Understanding development and cellular plasticity in the pancreas in health and disease dlvr.it/TSXJ51
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Spagnoli Lab retweeted
Drs. Alejo Torres-Cano (@LabSpagnoli) and Francesca Spagnoli explore how cellular plasticity and microenvironmental interactions drive #PancreaticDevelopment, regeneration, and disease, with implications for therapies for diabetes and pancreatic cancer.
Read the #review in @NatRevGastroHep: go.nature.com/4fjnL3m
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May 8
🎉 Very happy to have had the opportunity to contribute to this latest @DiseasePrimers #Review on #PancreaticCancer together with a number of great colleagues! @ednacukierman @EileenMOReilly @SaurLab @BarbaraGrnwald ...
Hope it is a useful read! 😊💜
nature.com/articles/s41572-0…
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Apr 28
My department at Oxford is recruiting junior faculty to the Ludwig Institute for Cancer Research. A collaborative and stimulating department, with great access to the breadth of the Oxford environment. The positions come with core funding and cutting edge technologies. If interested, apply here: shorturl.at/1ggGt
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Spagnoli Lab retweeted
14 Dec 2025
Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids biorxiv.org/content/10.64898… #biorxiv_devbio
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Spagnoli Lab retweeted
New research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬
kcl.ac.uk/news/research-reve…
Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791
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24 Nov 2025
🚨 here it is the #DashBoard accompanying our new paper (see 🧵 below)
➡️ spatial-pancreatic-maps.site…
😃 have fun exploring the dataset & #spatial #maps 🗺️
👏 👏 Kudo to Sami (#SiwanartaMa) MSc Bioinformatics for building the #DashBoard !!
13 Nov 2025
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations
Alejo Torres-Cano, who led the study
past & current team @LabSpagnoli
collaborators #VigilanteLab
@kingsmedicine
➡️ doi.org/10.1126/scia...
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13 Nov 2025
Spatially organized cellular communities shape functional tissue architecture in the pancreas | Science Advances science.org/doi/10.1126/scia…
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13 Nov 2025
Congrats Alejo Torres-Cano postdoc in the @LabSpagnoli @KCLstemcells
13 Nov 2025
🕰️ Alejo Torres-Cano and team at @KingsCollegeLon combine single-cell and spatial transcriptomics to map pancreatic cell populations across space and time, from embryonic development to adult homeostasis in mice.
@ScienceAdvances | bit.ly/4pcQAQR
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13 Nov 2025
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations
Alejo Torres-Cano, who led the study
past & current team @LabSpagnoli
collaborators #VigilanteLab
@kingsmedicine
➡️ doi.org/10.1126/scia...
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13 Nov 2025
We built ‘maps’ 💻showing that pancreatic progenitors and nearby supporting cells form niches &
used #stemcells 🧫to recreate pancreatic niches in the lab 🧪 & study how human beta cells develop
🙏 the Editor #ScienceAdvances & reviewers for great insights and comments
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13 Nov 2025
🙏🙏 all our fundings @EUCouncil @wellcometrust
@NC3Rs #FundaciónAlfonsoMartínEscudero #postdoc support
@KCLBMBioscience
@BT1DUK #T1DGrandChallenge @DiabetesUK for next step of these discoveries
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7 Oct 2025
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2 Oct 2025
📢 📢Delighted to announce our latest pre-print co-led by our fantastic and talented postdocs @IreneFaravelli and @bolanosAnton 👩🏻🔬👩🏼🔬💪! Human cortical organoids record developmental time for 5 years in vitro. 🧫🧠⏳. A huge collaborative effort, big thanks to all co-authors! 🧵👇
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Spagnoli Lab retweeted
16 Jun 2025
Dr. Lori Sussel, Director of the CU Diabetes Research Center, recently delivered a keynote lecture titled “Unraveling the Regulation of Islet Cell Fates” at the European Islet Study Group Meeting in Malmö, Sweden. The event was hosted by the Lund University Diabetes Center.
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Spagnoli Lab retweeted
18 Jun 2025
Image analysis opportunity in our lab @TheCrick - deadline June 25
crick.ac.uk/careers-study/va…
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2 Jun 2025
My Lab. and I are doing it again!!
🚶♀️🚶🏃♀️10K One Walk London for T1D research !!!
Please help us raise funds for Breakthrough T1D!
Your support will help change the lives of everyone affected with T1D - Thanks so much!
support.breakthrought1d.org.…
@BreakthroughT1D
@BT1DUK
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4 May 2025
Join us in Lausanne 🇨🇭 for the Lac Léman Regenerative Medicine Symposium, Sept 17–19, 2025! 🔬
Stem cells, aging, bioengineering — shaping the future of regenerative medicine.
habiblab.org/l2rm
🎟️ Students 25 CHF | Postdocs/Faculty 50 CHF | Industry 150 CHF
#L2RM
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