Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of 500K mutations across 522 domains. The study by @BenLehner and Toni Beltran @mutatoni is out in @Nature. ✍️ Illustration by @QueraltTolosa

The genetic architecture of protein stability by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel nature.com/articles/s41586-0… @CRGenomica @sangerinstitute @ALLOXbio

Excited to share @AlbertIltirda's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with @aj4re @CRGenomica @sangerinstitute biorxiv.org/content/10.1101/…

How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s41588-0…

The gut microbiome influences metabolites, hormones and immune function Perturbing gut microbiota therefore impacts homeostasis across somatic tissues Could it also affect the reproductive system - and even offspring? See our results👇& tweetorial🧵 rdcu.be/dGpoc

That's the Src kinase domain alone. Here's the allosteric map of the kinase domain in the context of the full-length protein ( SH2, SH3, SH4 etc).

Thread by @ToniBeltran13 about the Src kinase allosteric map. And here is one view of the map. @CRGenomica @sangerinstitute

Excited to share a new, MUCH IMPROVED version of our deep indel mutagenesis (DIM) manuscript: biorxiv.org/content/10.1101/… See the thread below for details.

Very happy to share what I've been working on in Barcelona with @BenLehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)

Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.1101/…

Excited to finally share some of my PhD work on quantifying the effects of indel mutations on protein stability and function using deep mutational scanning. From sunny @CRGenomica together with @ToniBeltran13 and guidance from @BenLehner biorxiv.org/content/10.1101/…

New preprint from the lab: Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function. First paper from Magda with @ToniBeltran13 biorxiv.org/content/10.1101/…

Interested in spending 5 months in @CRGenomica Barcelona 🌊and learning how to CRISPR ✂️🧬? We @mirimiam are looking for a paid 💸 intern that will work on genome engineering using stem cells. Salary & relocation flights covered. More details here: crg.eu/en/content/training/u… 1/2