A global collaborative center with groundbreaking imaging tools & technical expertise to tackle large scale imaging data projects
Joined July 2019
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10 Photos and videos
Advanced Bioimaging Center @ UC Berkeley retweeted
Jun 12
Our June issue is live! š
nature.com/nmeth/volumes/23/ā¦
On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope.
Paper here: nature.com/articles/s41592-0ā¦
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Advanced Bioimaging Center @ UC Berkeley retweeted
May 27
One microscope, every scale. MOSAIC images life from single molecules to whole organisms: dividing cells, remodeling organelles, regenerating zebrafish, Alzheimer's tissue at the nanoscale, live mouse neural dynamics. Credit: Fu, Liu, Milkie, Ruan et al., Nature Methods (2026).
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Advanced Bioimaging Center @ UC Berkeley retweeted
May 22
Congrats to all 49 authors on the publication of our paper on the multimodal MOSAIC microscope, to be found here: nature.com/articles/s41592-0ā¦
A summary with movies I posted nearly a year ago can be found below.
21 Jul 2025
1/ Better late than never, hereās a long thread of threads summarizing our MOSAIC preprint.
If youāre curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If youāve come for eye candy, thereās plenty of that too below.
biorxiv.org/content/10.1101/ā¦
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Advanced Bioimaging Center @ UC Berkeley retweeted
May 22
MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @Eric_Betzig @ABCUCBerkeley @legant_lab
nature.com/articles/s41592-0ā¦
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We are recruiting an instrumentation scientist! aprecruit.berkeley.edu/JPF05ā¦
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Advanced Bioimaging Center @ UC Berkeley retweeted
2 Dec 2025
š¬š¦Check out our āImaging spotlightā on Volumetric Imaging via Photochemical Sectioning (VIPS) from @Ruixuan3, Srigokul Upadhyayula and colleagues.
VIPS helps researchers scale super resolution imaging to large whole-mount tissues.
focalplane.biologists.com/20ā¦
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Advanced Bioimaging Center @ UC Berkeley retweeted
16 Oct 2025
A new method called VIPS enables organ-wide nanoscale reconstruction for quantitative mapping of connectivity and molecular landscape in intact tissue.
Learn more this week in Science: scim.ag/3LdbQqH
ALT This three-dimensional rendering of a mouse olfactory bulb exposes axons and myelin sheaths, the neuronal wiring that transmits odor information.
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Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM photodegradable hydrogel petabyte-scale compute ā axons & myelin across mouse olfactory bulbs (WT vs NPC1).
ALT Cover: 3D WT bulb, wedge-out view; VIPS alternates light-sheet imaging & photochemical sectioning.
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This work was made possible in part by support from @cziscience @czbiohub @SloanFoundation @BerkeleyLab @HHMINEWS @ThePhilomathia @NIH @NERSC
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Advanced Bioimaging Center @ UC Berkeley retweeted
2 Oct 2025
Adaptive optical vision Fourier transformer (AOViFT): a machine learning framework for inferring image aberrations and restoring diffraction-limited performance.
nature.com/articles/s41592-0ā¦
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Advanced Bioimaging Center @ UC Berkeley retweeted
21 Jul 2025
1/ Better late than never, hereās a long thread of threads summarizing our MOSAIC preprint.
If youāre curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If youāve come for eye candy, thereās plenty of that too below.
biorxiv.org/content/10.1101/ā¦
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Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling nonāinvasive ināvivo imaging from molecules to organisms, is out.
biorxiv.org/content/10.1101/ā¦
@Eric_Betzig @legant_lab
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Advanced Bioimaging Center @ UC Berkeley retweeted
16 Jun 2025
The MOSAIC reconfigurable microscope by @Eric_Betzig et al is finally out!
MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics:
biorxiv.org/content/10.1101/ā¦
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Advanced Bioimaging Center @ UC Berkeley retweeted
21 Oct 2024
Unlocking the potential to image petabyte-scale datasets šµāš«! From #CZBiohubSF InvestigatorĀ Gokul Upadhyayula and co-corresponding authors &Ā @BerkeleyMCB colleagues Xiongtao Ruan and @Eric_Betzig.
17 Oct 2024
Out today from Ruan, Betzig, Upadhyayula and colleagues! PetaKit5D offers versatile processing workflows for petabyte-scale light sheet microscopy data. nature.com/articles/s41592-0ā¦
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We are excited to introduce PetaKit5D, a comprehensive suite of software tools designed to tackle challenges in the handling of large datasets and make processing of petabyte-scale datasets feasible: nature.com/articles/s41592-0ā¦
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PetaKit5D is a scalable and efficient software for processing large datasets from light sheet microscopy and other imaging modalities. It is available for use in MATLAB and Python, as well as a GUI that requires no coding. Try it and share your feedback!
github.com/abcucberkeley/Petā¦
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This work was led by Xiongtao Ruan and Matthew Mueller @ABCUCBerkeley @Eric_Betzig @berkeleyMCB @LBNLBioSci @LBNLresearch, and supported by @ThePhilomathia @czi @cziscience @HHMINEWS @HHMIJanelia @NERSC @SloanFoundation
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Advanced Bioimaging Center @ UC Berkeley retweeted
17 Oct 2024
Almost everyone in microscopy (especially LSFM) talks about data deluge, but the tools haven't kept apace with the problems. Check out PetaKit5D for processing and analyzing your huge datasets!
17 Oct 2024
Out today from Ruan, Betzig, Upadhyayula and colleagues! PetaKit5D offers versatile processing workflows for petabyte-scale light sheet microscopy data. nature.com/articles/s41592-0ā¦
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