Good readers make good writers. The #papers365 accountability account of a new PI (@Annika_Barber). Mastodon: @papersofnote@drosophila.social
Joined June 2020
- Tweets 7,087
- Following 17
- Followers 1,046
- Likes 314
129 Photos and videos
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18 Jun 2022
Also...🚨THIS IS PAPER #730!!!🚨 I really read, and tweetorialized, 730 papers in 730 days! Stay tuned for statistics and the top 20 favorites of 2021-22. You can see all the papers I've read here, with links to tweetorials: docs.google.com/spreadsheets…
18 Jun 2022
Human body temperature rhythms have been noted since the 1840s, but what about brain temp? Brain temp management is a keystone of neuroprotective ICU treatment, but turns out we don't know what temp your brain should be when! 😱 @neurocool to the rescue. doi.org/10.1093/brain/awab46…
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6 Nov 2024
I can't justify staying in this space. This account will be deleted within the next ~48 hours as soon as I have a current backup of my tweets for my personal notes. I'd love to see you on 🦋! Or email me your papers! Or see me IRL!
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1 Jul 2024
If you missed hearing about papers - I got you! July special edition #papers365 on Bsky! Username is annikabarber.
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1 Jul 2024
I don't log in here more than once every 6 months or so - find me elsewheres on the internets.
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13 Jul 2023
Annika is still reading, but mostly board books because she has a new grandbaby and is helping with grand baby #1! Will return to tweeting papers when I'm done with "But Not the Hippopotamus." 🦛
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7 Jul 2023
Desert Drosophila have hard lives...and they sleep more! @party_mcfly_ and not-on-twitter colleagues in the Donlea lab show that D. mojavensis not only sleeps more than melanogaster, they *increase* sleep with food and water deprivation. 🪰🌵doi.org/10.1101/2023.05.27.5…
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7 Jul 2023
But *why* do desert flies sleep more? They turn out to be very resilient to food and food water deprivation, with elevated sleep time upon nutrient deprivation. Survival during nutrient deprivation was correlated with increased sleep in the Mojave subspecies.
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7 Jul 2023
Many animals show sleep *loss* during stress, but D. mojavensis sleeps more during nutritional stress and this seems to provide survival advantages. Mechanism TBD, but could be related to waste clearance or energy use. A cool new phenomenon to understand sleep evolution!
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6 Jul 2023
I love a co-transmission mystery story, and @GriffithFlyLab delivers! Gal4 reporters suggest that glutamatergic and gabaergic fly neurons also express acetylcholine. But fluorophore-tagged transporter genes show no overlap...the secret sauce is microRNA. doi.org/10.1126/sciadv.adg98…
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6 Jul 2023
Another piece of evidence used a split GFP on VGAT and VAChT, which would only assemble and fluoresce if both transporters were in the same vesicle and there is signal, which increases in older flies (30 days).
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6 Jul 2023
All this suggests that flies have miRNA regulated tuning of cotransmission in Glu- and GABA-ergic neurons, which may be dynamically regulated by environmental conditions, allowing neurons to rapidly change the magnitude or even sign (Glu & GABA are inhibitory, ACh is excitatory).
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6 Jul 2023
Just so y'all know, I also read fiction, and I keep a spreadsheet of that too. Unlike papers, I give everything book a 1-5 rating! 🔥 (Or DNF if it's really bad).
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5 Jul 2023
How early do babies get circadian rhythms? Not soon enough amiright? 😅 Keenan Bates in @ErikHerzog's lab finds that mice develop fetal rhythms in sync with mom as early as embryonic day (E)15.5! That's about 75% of the way through gestation. doi.org/10.1101/2023.06.30.5…
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5 Jul 2023
E15.5 is already known to be a critical time in maternal-fetal communication, as it's when 11β-hydroxysteroid dehydrogenase (11β-HSD) levels drop in the placenta, which could allow maternal glucocorticoids to avoid inactivation and entrain fetal rhythms.
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5 Jul 2023
This imaging paradigm is looking at whole fetus PER2::LUC, and isn't describing whether the SCN is wired up and rhythmic. So I'm curious what happens after birth when the pups no longer have a maternal entrainment signal, and their own brain clock is probably not quite wired up.
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