Neuroscience stuff | Postdoc @Stanford_PMHW | github.com/adpines |

Joined September 2018
48 Photos and videos
pines retweeted
May 16
PNAS Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function This study developed a new brain stimulation method called traveling-wave transcranial alternating current stimulation (twtACS). Unlike conventional brain stimulation, twtACS creates electrical waves that move across the brain in a specific direction, similar to natural neural traveling waves. The researchers showed that these artificial traveling waves could: Change the timing of neural activity in the brain Control how signals propagate across brain regions Improve cognitive performance in humans depending on the direction of the wave They confirmed these effects using: Human intracranial recordings Monkey neural recordings Human behavioral experiments The study suggests that traveling waves are not just correlated with cognition but may causally influence cognitive function. This introduces a new way to noninvasively manipulate brain communication and potentially treat neurological disorders. pnas.org/doi/full/10.1073/pn…
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pines retweeted
How does TMS — a treatment for depression — reshape dysfunctional brain circuits? In our new Cell paper, we identify a cell type-specific prefrontal mechanism linking accelerated iTBS to antidepressant-like behavioral effects and circuit plasticity. cell.com/cell/fulltext/S0092…
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pines retweeted
What are the neural correlates of human behavior? Much research has approached versions of this question between individuals but not within individuals. Are results from these 2 approaches similar? No! In over 4000 individuals, the neural correlates of cognitive control diverged between vs. within individuals -- a case of non-ergodicity and Simpson’s paradox. We think that non-ergodicity may be an important principle in human neuroscience. [1/12]
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pines retweeted
Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development. 🔗 bit.ly/3QMLG0K
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pines retweeted
Our first work from my PhD period: biorxiv.org/content/10.64898… In this study, we propose a computational model and theoretical framework for neural dynamics. This is only a starting point, but it also reflects our broader academic ambition.
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pines retweeted
We think of white matter as highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My PhD paper, “Two Axes of White Matter Development”, is now out in @NatureComms!🧠 🔗bit.ly/wm2axes
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pines retweeted
My second first author paper of graduate school - Sex differences in response to violence: role of salience network expansion and connectivity on depression - is now published in Translational Psychiatry! rdcu.be/eLYg6

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pines retweeted
30 May 2025
Emotions are core to the human experience 😆😮🙂😊☹️😠😳😑. But how do they arise? Our brain-wide ⚡recordings in humans and mice reveal some answers @ScienceMagazine. A big team effort and debut paper from @Stanford's new Human Neural Circuitry program. bit.ly/4dEyX7Z
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5 May 2025
Congrats Paula!!
🧵1/7 New paper out! We explored how cognitive behavioral therapy (BIT ) affects brain activity & inhibitory task performance in hoarding disorder. Thankful for @CRodriguezMDPhD @LMWilliams_PhD @pineurosci @pineurosci @Stanford_PMHW @warmxue mentorship! sciencedirect.com/science/ar…
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22 Apr 2025
The electric fields given off by TMS are super distributed: this is a great one for piecing apart the implications of that spread for individual treatment outcomes. Congrats Divya!
Check out our recent work demonstrating that the scalp-based Beam/F3 method is a reliable way to target the dLPFC in #TMS for depression! We learn more by integrating personalized E-field models… 👀 With @NoahSPhilipMD, @LMWilliams_PhD, and others. 👉 sciencedirect.com/science/ar…
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pines retweeted
Breathing isn’t just for life—it’s a brain pacemaker! This excellent review reveals how each breath sends sensory waves that globally synchronize neural networks - with implications for "functional connectivity". Congrats to the authors! 👉 doi.org/10.1038/s41583-025-0…

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pines retweeted
‼️PhD Position now available in my lab‼️ Do you like: * Neurodegenerative disease? * Neuroimaging and/or multi-omics? * AI and data-driven life science? Want to work with @RikOssenkoppele Alexandra Young and Laura Wisse? Apply here: lu.varbi.com/what:job/jobID:… Please rt/share 🙏
Whelp. Maybe a good time to mention that I am about to open a new PhD position in Sweden that just happens to be exactly four years in length. Any aspiring PhD candidates in neurodegenerative imaging or multiomics who want to "take a break" from the US, please get in touch!
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21 Mar 2025
Seems relevant to all the white matter targets popping up in brain stim. Not just a highway anymore!
20 Mar 2025
We think of white matter as the brain's highways—uniform conduits between cortices. What if we study development along tracts? Turns out the journey matters as much as the cortical destination! We're thrilled to share “Two Axes of White Matter Development”bit.ly/wmaxes
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pines retweeted
20 Mar 2025
Thrilled to announce our study, “Connectional Axis of Individual Functional Variability: Patterns, Structural Correlates, and Relevance for Development and Cognition,” now published in @PNASNews pnas.org/doi/abs/10.1073/pna…
Excited to share our work “Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition,” now out at @PNASNews pnas.org/doi/10.1073/pnas.24….
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Our preprint detailing our novel approach to identifying personalized neuromodulation targets to treat severe, refractory OCD using brain mapping is now out on MedRxiv. Here, we describe our first SEEG-guided DBS case for OCD at UCSF: medrxiv.org/cgi/content/shor…

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pines retweeted
(1/17) Now out on bioRxiv‼️Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025.02.24.6… Funded by @NIMHgov

Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health biorxiv.org/content/10.1101/… #biorxiv_neursci
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12 Feb 2025
!!!
What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵 jamanetwork.com/journals/jam…
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pines retweeted
Now out in @NatMentHealth 🥳🥳🥳 this is the 2nd study of my dissertation with Carrie Bearden, co-led with @dehughes14 💫💫nature.com/articles/s44220-0…

Check out @Sarah_Chang_ 's and my latest preprint: medrxiv.org/content/10.1101/…. We investigate the effects of attention and probe the developmental specificity of polygenic signal on psychotic-like experiences in adolescents using ABCD.
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pines retweeted
Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations biorxiv.org/cgi/content/shor… #biorxiv_neursci

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