Following President Trump’s directive to accelerate medical treatments for serious mental illnesses, FDA announced major steps to support the development of serotonin-2A agonists & related products—a class of medications historically referred to as "psychedelic" drugs. ✅ National priority vouchers for psilocybin (for treatment-resistant depression and major depressive disorder) ✅ National priority voucher for methylone (for post-traumatic stress disorder) ✅ First-ever noribogaine study authorized for alcohol use disorder ✅ Advancing guidance for sponsors developing these products Learn more: fda.gov/news-events/press-an…

This is intramuscular 5-MeO-DMT. 1g/10mL, synthetic, pharmaceutical-grade. It's also what Bryan Johnson used when he livestreamed his session to 700,000 people last month. He didn't just smoke it. He was injected and vaporized back-to-back using something called the Leckie Protocol. Enfold Institute in British Columbia has developed the Leckie Protocol through 650 facilitated sessions since 2019, and it addresses a problem that has limited 5-MeO-DMT's work for years. Vaporized 5-MeO hits in seconds and produces the full ego-dissolving, somatic release that makes this compound unlike anything else in the psychedelic pharmacopeia. But it metabolizes fast. The peak lasts only minutes, and most people have limited memory of what actually happened. The experience is more of a physiological event than a cognitive process. Intramuscular 5-MeO takes 3-5 minutes to onset and extends the plateau to 30-45 minutes, giving someone time to consciously participate in what's happening. The catch is that the slower onset gives the ego time to reassert itself, which means the full dissolution that makes vaporized 5-MeO so distinct rarely occurs through IM alone. The Leckie Protocol sequences both. IM goes first, vaporized immediately after. You get the rapid full-saturation peak from the vapor, and as that begins to clear at the 4-5 minute mark, the intramuscular dose reaches onset and sustains the experience into a longer working window. Depth plus duration, something neither route achieves on its own. I want to be direct about something: this is not a casual compound, and this is not a protocol for self-administration. 5-MeO-DMT is the most intense psychedelic substance available, and intramuscular delivery adds pharmacological complexity that demands clinical-grade preparation: verified 99% purity, sterile injectable solutions, micron filtration, and lab-grade scales. Enfold runs a 2:1 guest-to-facilitator ratio, embeds the high-dose session on day three of a five-day intensive, and precedes it with a low-dose ceremony specifically to calibrate individual sensitivity before anyone goes deep. That level of structure exists because this compound requires it. The fact that this went mainstream through a livestream is a double-edged situation. On one hand, millions of people now know that 5-MeO-DMT exists and that serious practitioners are developing sophisticated methods of working with it. On the other hand, the spectacle format strips away every piece of context that makes the work safe and meaningful: the preparation, the screening, the facilitator skill, the integration afterward. The protocol matters more than the performance. What's your read on 5-MeO-DMT getting this kind of public exposure?

Ayahuasca, DMT, and Mental Health: A Current Review of Scientific Studies link.springer.com/article/10…

A rigorous paper published in Nature supports the idea that the Eleusinian Mysteries may have been a psychedelic-based religion. Plato, Aeschylus, Augustus, Marcus Aurelius, and Plutarch are just a few of the historically significant figures known to have participated in these rites. Given how profoundly our modern world is shaped by the ideas of these thinkers - from philosophy to governance - one could argue that Western civilization itself has, in part, been influenced by #psychedelic wisdom. Now, imagine for a moment how much more intellectually vibrant, thoughtful, and humane our world could become (again) if we responsibly reintroduced these medicines into society. nature.com/articles/s41598-0…

Someone asks me: "What entities have I experienced on DMT?" I could write several books about this, and maybe I will. I don't take the semantic content of psychedelic experiences literally. But it's still fascinating. I've had over 1,000 DMT experiences, same with 5-MeO-DMT, and I've encountered many "realms" and many different kinds of beings. I've always been fascinated by Buddhism, and recently I was reading about all the Buddhist heavens and hells, and the beings that inhabit them. It struck me that the entire Buddhist ecosystem of World Systems is a better guide for making sense of these intelligences than, say, simply "advanced ETs", "fallen angels", or "trickster beings". It really is a UNIVERSE or MULTIVERSE out there! There's a vast combinatorial explosion of things that may happen. I sort of understand, I think, the basic principles for how these experiences unfold and why they feel the way they do. But I would say I've only begun to really explore the intelligences that live and emerge in them. Knowing a certain magical number for a dynamic system vs. truly knowing in practice what you can do with it are two very different things. Some of the realms are actually very endearing and friendly. For example, what I now associate with the "Heaven of the Four Kings" in Buddhism is a place that rests "right above us" and is like this universe but just a bit more pleasant, peaceful, and magical. I don't mean to overfit on Buddhism, but the descriptions they use are genuinely evocative. Here you'll see small light beings, fairies, gnomes, magical turtles, strange looking mushrooms, and a lot of cute beings that have the vibe of being like kids or innocent creatures, half-animal half-magical. I get the impression the place is governed by a vast benevolent intelligence that functions as, more or less, a parental figure making sure these beings don't fight each other and are well fed. Like a vast zoo of peaceful, but sometimes a bit selfish, beings that love to bask in the sun, hang out in meadows, enjoy pretty bell music, and look at fireflies next to an enchanted tree. Go a bit further up and you experience more sophisticated aesthetic beings. Beings that make works of art with their mind, and assemble to perform plays for each other. More or less as intelligent as humans but clearly more "spiritual" and "emotional." Further up there is a realm of beings who "sing with their emotions" and don't care about external sensory pleasures anymore. Further up yet and you encounter beings whose body is just light and "glass" or some kind of semi-transparent media. Further up and there are beings who embody pure space or pure "being" and often believe they're God. And then on strange trips, sometimes I go "sideways" to other world systems, where the more blatantly hyperdimensional beings come from. These feel less like a level of reality and more like entities from an entirely different parallel universe with different laws. Some of these beings feel to me as profoundly benevolent. Others are neutral. And certainly there are negative, parasitic ones too. There are big "hubs" where many realities and world systems meet, and there you might encounter vast Buddhaminds that work as a kind of traffic controller and priest, purifying and clarifying the minds of those who get near. You also "become" part of it when you are near it, but this feels very beneficial and illuminating. Like mindmelding with a cross between a saint and a mathematical genius. I absolutely love this realm, and have only experienced it a handful of times (probably 4, maybe 5). But there are also hypertechnological realms. I've been "oriented" to the Galactic Federation, or whatever that was, and shown a vast network of civilizations a bit more advanced than Earth. This one feels very good and positive. But there are also "rogue" civilizations that don't want to be part of it, and are critical of the collective. They would take over if they could. While I said I don't take this content literally, I do find it fascinating and a valuable object of study. Why these semantic landscapes? Why these textures of meaning? The QRI perspective (3D tactile field mapping to 2.5D visual field in multiple ways at once, giving rise to exotic resonant modes, annealing, Bayesian energy sinks, emergent hyperbolic geometry, liquid crystals, recursive beamsplitter architecture, etc.) has a lot to say about this, but it still feels weird and unusual. And, frankly, at least some of the hyperdimensional beings escape even my most ambitious mathematical modeling of the phenomenology. This doesn't stop me from trying to figure it out. And I'm optimistic our modeling is getting genuinely closer to the phenomenon. Just a few more years of study and we will have figured it out, promise! :-)

The Transfiguration and the glorified body of Jesus are one and the same: the plasma body, or the Tibetan Rainbow Body, a form made of pure energy. He can appear however He wants before His disciples because He can control what they perceive. The plasma body can manipulate the fabric of material reality; it is a form capable of influencing electromagnetic waves. You can also achieve this body, it will come naturally at the end of the cycle, or you can accelerate the process. This is what Jesus was teaching; He did not want you to worship Him, but to believe in Him, follow His path, and make the same choices.

After a century of searching, a student found the LSD-like fungus. For centuries, Indigenous peoples in Mesoamerica have used morning glory vines in sacred rituals, thanks to the vines’ potent psychedelic seeds. Scientists knew these seeds contain ergot alkaloids—powerful compounds from the same chemical family that eventually gave rise to LSD—but there was a persistent puzzle: plants don’t make ergot alkaloids. Only certain fungi do. Yet no one, not even Albert Hofmann (the chemist who discovered LSD in the 1930s), could find the fungus living inside the plant. Then a college student cracked the mystery. Corinne Hazel, an undergraduate studying environmental microbiology at West Virginia University, was examining seeds of the popular “Heavenly Blue” morning glory when she spotted an almost invisible layer of fuzz on the seed coat. Under the microscope and through DNA analysis, that delicate fuzz revealed itself to be an entirely new species of fungus, now formally named Periglandula clandestina—a nod to its secretive, clandestine lifestyle. The fungus lives in quiet symbiosis with the vine, producing ergot alkaloids that almost certainly defend the plant against herbivores while also delivering the mind-bending effects humans have sought for generations. Hazel’s find does more than close a long-standing scientific whodunit. It has immediate implications for medicine, agriculture, and neuroscience. Modern researchers are already investigating ergot alkaloids for treating migraines, Parkinson’s, dementia, and other conditions. Understanding exactly how this hidden fungus manufactures the compounds could help develop safer, more precise versions of these drugs—and perhaps prevent the occasional outbreaks of ergot poisoning that still plague grain crops. What began as a student’s close look at a garden flower has quietly rewritten a chapter of botany, mycology, and psychedelic history. ["WVU student discovers long-awaited mystery fungus sought by LSD’s inventor." WVU Today, 2025]

From one brain to 29: How 5-MeO-DMT research evolved from ceremonial EEG caps to peer-reviewed Cell Reports. The science is finally catching up to what pioneers mapped a decade ago. adultintraining.us/post/from… #5MeODMT #Psychedelics #Neuroscience #PsychedelicScience

The Sufi mystic Rumi says, ‘Everything in the universe is within you. Ask all from yourself.’ And this is true in all religions. Jesus says the Kingdom of God is within you. Your soul is a portal to the stars, and only by purifying your heart can you reach the Divine Throne.

A significant portion of known psychedelics were discovered because Alexander Shulgin invented the first biodegradable pesticides for Doe Chemical. As thanks, they built him a lab, fully funded it, and gave him full autonomy over his research. He spent the rest of his life synthesizing and self-testing hundreds of phenethylamines and tryptamines, the two major classes of psychedelic compounds.

Aya: Awakenings is a documentary journey into the world and visions of Amazonian shamanism, adapted from the cult book 'Aya: a Shamanic Odyssey' by Rak Razam. Get it here: buff.ly/XXGEqDh

Rak Razam talks with independent researcher, author and lecturer Jan Irvin from Gnostic Media about his forthcoming documentary on Gordon Wasson, an influential New York banker and the godfather of the modern psychedelic movement. Listen here: buff.ly/t2n5CUH

In this continuation of In a Perfect World 33, Rak interviews author and academic Robert Forte about the origins of the Psychedelic Movement and its manipulation by the power elites as a social engineering tool for control. Listen here: buff.ly/JtNPWYF

"A regular series of 'experiential journalism' podcasts exploring the evolution of the new global paradigm. In a Perfect World will chart the meetings, musings and collective dreamings of gonzo reporter Rak Razam." Get it here: buff.ly/DtsSKLc

Experiential journalist Rak Razam chats with "radical anthropologist" and global freakologist Graham St John about the evolution and current direction of Global Trance Culture. Listen here: buff.ly/SbJJEQn

Rak talks with Kilindi, an African-American warrior-teacher who works with psilocybin mushrooms as entheogenic guides in mapping the inner realms. Listen here: buff.ly/h3HpnVu

Join Rak and Rev. Aryshta, Dean of the Sacred Foundation, an organization dedicated to re-establishing the sacred traditions of ancient mystery schools and their entheogenic usage. Aryshta is a modern-day Priestess of Isis... Listen here: buff.ly/miWBRHq

Rak delves deep into an intimate discussion with psychotherapist, Navigating Altered States practitioner and Tantric Sex coach Meriana Dinkova about the mind, body, and soul connection. What are the connections between flesh and spirit? Listen here: buff.ly/39eGtaQ

On a noisy karmic car ride to Uki, in Northern New South Wales, with my good friend and cosmic sister Phe Gitsham. Chinese medicine practicioner, dream-shaman, pre-cog, trance medium, nagual... Listen here: buff.ly/WuC1xI0

Rak gets all down-to-earth with Shane and Margaret, shamanic practitioners 'not shamans!' in Australia, trained in the Peruvian style with both Wachuma and Ayahuasca entheogenic sacraments... Listen here: buff.ly/y89IJHA