Joined August 2017
- Tweets 223
- Following 88
- Followers 333
- Likes 143
36 Photos and videos
29 Oct 2025
🚀 New preprint from @epfl_en’s Laboratory of Computational Systems Biotechnology (LCSB)!
We present “Multi-omics–driven kinetic modeling reveals metabolic vulnerabilities and differential drug-response dynamics in ovarian cancer.”
🔗 biorxiv.org/content/10.1101/…
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29 Oct 2025
By integrating multi-omics data with enzyme kinetics, we generated a population of near–genome-scale kinetic models that capture BRCA1-mutant vs wild-type ovarian cancer physiology.
These models reveal network-wide control principles & drug-response dynamics.
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29 Oct 2025
This work by Toumpe, Masid, Hatzimanikatis & Miskovic (@epfl_en LCSB) provides a resource for exploring metabolic regulation, vulnerabilities, and precision oncology.
All models are openly available.
#systemsbiology #cancermetabolism #multiomics #precisiononcology #openscience
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the real LCSB retweeted
15 Aug 2025
Our review made the cover in ACS Synthetic Biology! 🎉🧬
We explore how large-scale kinetic models are shaping the future of metabolic engineering — check it out here 👉 pubs.acs.org/toc/asbcd6/14/8
Big thanks to the team and @ACSPublications! #MyACSCover #SyntheticBiology
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13 Aug 2025
Excited to share our new preprint, where we present NIS, a framework that distills GEMs into interpretable modules, enabling direct cross-species comparisons of fueling pathways, biosynthesis, and environmental exchanges.
Congratulations to the authors!
13 Aug 2025
đź‘Ź A big thank you to my co-authors Meric Ataman & Vassily Hatzimanikatis for this great collaboration!
🔍 Read more: doi.org/10.1101/2025.08.08.6…
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12 Mar 2025
Our latest work on Salmonella metabolism in the murine gut is now at @PLOSCompBiol ! Congratulations to the authors @EVayena, @FuchsiLea, @HomaMP4, Konrad Lagoda, Bidong Nguyen, Wolf D. Hardt, and @vassily_13!
journals.plos.org/ploscompbi…
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the real LCSB retweeted
18 Dec 2024
This work showcases one of the few successful integrations of kinetic modeling and experiments to optimize cell factories. It highlights the power of NOMAD (nature.com/articles/s41467-0…) in accelerating and improving strain design!
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the real LCSB retweeted
18 Dec 2024
Excited to share our preprint on boosting p-coumaric acid production in S. cerevisiae! 🎉 In collaboration with Irina Borodina's group (@Irina__Borodina), we used our NOMAD framework for strain design strategies. Read more: biorxiv.org/content/10.1101/…
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30 Aug 2024
A new baby from our creative workshop:
30 Aug 2024
Want to efficiently create large-scale dynamic models of metabolism that fit experimental data and reliably predict metabolic responses to various perturbations? Our new method does just that! Check it out here: nature.com/articles/s41929-0….
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4 Jul 2024
We are thrilled to announce that our generative ML method for kinetic modeling (biorxiv.org/content/10.1101/…) has been accepted to @NatureCatalysis. Congratulations to Subham (@astro_dank), Bharath (@bharathnarayana), Michael (@moret1788), Vassily (@Vassily_13), and Misko (@Misko_L34)
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22 Jun 2024
12 Jun 2024
Happy to share a preprint of our new work in which we combined graph-search algorithms and constraint-based optimization to find the best retrobiosynthesis pathways for producing valuable compounds in a host biorxiv.org/content/10.1101/…
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22 Jun 2024
Our latest work is now out at Metabolic Engineering! Congratulations to the authors @oftadehomid and @Vassily_13!
22 Jun 2024
Our new paper describes how computational models can capture the #plasmid metabolic burden and help optimize #recombinant expression of proteins
sciencedirect.com/science/ar…
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7 Feb 2024
Our recent publication in @NatureComms, “Rational strain design with minimal phenotype perturbation” by Narayanan et al., has been showcased in the recent Editors’ Highlights for Biotechnology and Methods focus (nature.com/collections/idhhg…).
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7 Feb 2024
Congratulations to Bharath (@bharathnarayana), Daniel (@realDRWeilandt), Maria, Misko (@Misko_L34), and @Vassily_13 for this nice work (nature.com/articles/s41467-0…)
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1 Feb 2024
Check out our preprint on now on bioaRxiv!!!
Congratulations to all the authors! @oftadehomid @aslisahin2205 @EVayena @vassily_13
1 Feb 2024
A preprint of our recent work is now available! In this paper we present a framework to infer nutrient competition and cross-feeding in microbial communities. Many thanks for the support we received from @NCCRMicrobiomes.
biorxiv.org/content/10.1101/…
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the real LCSB retweeted
25 Jan 2024
Our latest work on metabolic engineering using kinetic models and process systems engineering methods is out nature.com/articles/s41467-0…! Congrats to Bharath (@bharathnarayana), Daniel (@realDRWeilandt
), Maria, Misko (@Misko_L34), and @Vassily_13
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27 Sep 2023
Excited to announce that our latest work in now online ! This time the team significantly expanded on their previous tool, BridgIT, an enzyme annotation for orphan and novel reactions, to bring you the new and improved BridgIT ! Read the thread below to find out more :)
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27 Sep 2023
Curious and want to dive deeper? Check out our preprint on Bioarxiv: biorxiv.org/content/10.1101/…
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27 Sep 2023
Congratulations to all the authors for this fantastic achievement! Homa (@HomaMP4), Anastasia (@AnastasiaSves), Misko (@Misko_L34) and Vassily (@vassily_13) !!
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