Very cool structural biology and molecular pharmacology study on psychedelic mechanisms of action.
But, I cringe at references to hallucinations in mice, even with qualifiers about limitations of animal models. We need to be more precise in our descriptions of animal behavior!
🚨 The NO TRIP mushroom for depression
We finally know how psychedelics cause hallucinations vs. therapeutic effects at the 5-HT2A receptor.
Gi signaling drives the trip, Gq drives the relief.
And they just designed a non-hallucinogenic analog to prove it 🧵