Technology. Personal Science. Microbiome. Quantified Self. #DeSci. China 中国 Japan 日本. Longevity. Linguistics. Heideggerian AI richardsprague.eth

Joined October 2007
813 Photos and videos
LLMs are fundamentally just “transformers” that convert one series of tokens/text into another. Meanwhile, we humans are very good at remembering stories and social relationships. Here’s a brilliant idea to “translate” the complicated facts about cell biology into memorable stories and characters. This could work for lots of things that are ordinarily hard to remember lesswrong.com/posts/BJ7AqXei…
30
Cancelled my @evernote account at last. I've been a paying member since 2009, but their $275/yr price change was too much for me. Claude helped me migrate all 43k notes to Obsidian. So long!
6
494
Yup, I find Zipf characteristics in my own app and phone usage. Claude ActivityWatch makes analysis like this trivial open.substack.com/pub/person…
1
41
I used to read 50-100 books / year, but now I maybe read 5. AI, including “vibe-reading” is just a more productive use of my time. arnoldkling.substack.com/p/w… @KlingBlog

1
68
I tested the physician-grade @EvidenceOpen AI-driven clinical chatbot against Claude. Yes, it's nice that OpenEvidence uses top journals but I concluded that Claude is better for personal scientists. personalscience.com/p/person…
100
I've known for years that I'll feel more rested all day when I wake up with a low resting heart rate (RHR), but how can I reliably get there? I've been feeding a ton of detailed information into Claude the last few weeks and to my surprise it found one important driver I hadn't considered: the amount of protein I ate the day before.
1
77
I'm not quite ready to bet on this possibility but IMHO those open models are awfully good
Hard to see how any of the ai providers have any kind of moat. Claude is as per usual down so I just switched to @grok and ran my query through it. The result was more than sufficient and I solved my problem while Dario fails to populate his data centers with sufficient numbers of geniuses.
2
90
Another useless genetics report from @23andme . Why pay $100 to see if you _might_ be at risk when a $20 blood test can tell you for sure.
2
77
You’ve been wearing a fitness tracker for years. Isn’t it time to make a thorough long-term analysis with actionable, non-obvious conclusions? open.substack.com/pub/person…
52
“Beware of unearned wisdom” - Carl Jung
This was the most profound experience of my life. I am stunned beyond comprehension. This molecule is without peer. The 27mg dose opened up what felt like pure consciousness and intelligence. A majestic reveal of existence itself. In all its incomprehensible glory and majesty. It is impossible to explain with words. Whatever you imagine, multiply it by 1,000 and then add infinite width and depth and dimensions. But entrance was not granted without prerequisite. Existence demanded that I submit. That I say yes; without attachment and without condition. Yes to existence; yes to the dissolution of self; yes to release control; yes, to all. My ego registered the ask and panicked. It wanted control. It was desperate for control. It pleaded to escape from the torrent of light and essence that threatened to rip my sanity into chards. The urge to eject was overwhelming. Terror thundered throughout my mind and body. It took everything within me to release. I overcame and was treated with bliss that defies imagination. A euphoria colored with perfect harmony of all things. An orchestra of essence washed over me and swept me up in dance. It was home. The highest aspiration of intelligent life. For some reason, stored and tucked away as the ultimate prize. A single concept emerged in omnipresence: we cannot grok the preciousness of our existence. Yet it is everything we’ve ever wanted and more. The state we long for without knowing it exists. This caused me great pain and heartache. A swell of loyalty and devotion emerged inside me, pledging allegiance to existence. To become a warrior and caretaker of life on earth. To protect at any cost the candle of consciousness that has miraculously emerged in this part of the galaxy. What awaits will wipe all your tears, soothe all your sorrows, and infinitely exceed your wants.
59
Inevitably people will need to make peace with AI-generated writing. As LLMs get better and better, the commitment to "original creative expression and storytelling" will fade as we prioritize good writing regardless of the source.
1
1
55
I tried this popular ketone "energy-shot" and measured my ketones afterwards. Result: bubkas, nada, zilch. The reason: it's a fine drink, I suppose, but for people with my genes it does nothing. 1/2
1
71
Human challenge trials! Volunteers agree to be infected and try some new therapeutic -- it's a thing. I wonder how the rest of us can volunteer? @shelbynewsad . shelbyann.substack.com/p/sca…

1
2
2
522
Tons of new food products at @NatProdExpo last week, but I was most impressed by how Claude improved my workflow at big trade conferences: upload photos from each booth and auto-generate a summary personalscience.com/p/person…
48
We'll know AI has arrived when something like this has a noticeable affect on markets, a la Robinhood/Gamestop. Then come the regulators!
🚨 Someone just open sourced an AI hedge fund with 18 agents that think like Wall Street legends. Warren Buffett. Charlie Munger. Michael Burry. Cathie Wood. Bill Ackman. All running on your laptop. It's called AI Hedge Fund. You give it stock tickers. 18 AI agents analyze the company from every angle. Then they vote on whether to buy, sell, or hold. Not a toy. Not a dashboard. A full multi-agent investment research system. No Bloomberg Terminal. No $25K brokerage minimums. No financial advisor fees. Just AI agents doing what hedge funds charge 2-and-20 for. Here's who's on your team: → Warren Buffett Agent. Only buys wonderful businesses at fair prices → Charlie Munger Agent. Demands a margin of safety on every pick → Michael Burry Agent. The Big Short contrarian hunting deep value → Cathie Wood Agent. Innovation and disruption. High conviction growth → Bill Ackman Agent. Activist investor. Takes bold positions → Ben Graham Agent. The godfather of value investing. Hidden gems only → Aswath Damodaran Agent. The Dean of Valuation. Story meets numbers → Plus 11 more specialized agents covering technicals, sentiment, risk, and fundamentals Here's how it works: → You enter stock tickers (AAPL, NVDA, TSLA, whatever you want) → Agents pull real financial data. Earnings, balance sheets, insider trades, news → Each agent analyzes the data through their own investment philosophy → A Risk Manager agent checks position sizing and portfolio exposure → A Portfolio Manager agent takes all signals and makes the final call → You get a buy/sell/hold decision with full reasoning from every agent Here's the wildest part: You can turn on --show-reasoning and watch each agent explain their logic step by step. Warren Buffett agent breaks down the moat. Michael Burry agent flags the hidden risks. Cathie Wood agent finds the disruption angle. They literally argue with each other. It has a full backtester. Run your strategy against historical data and see how it would have performed. Full web UI included. Not just a terminal tool. A real dashboard. Works with OpenAI, Claude, Groq, DeepSeek, or fully local with Ollama. Your data never has to leave your machine. Data for AAPL, GOOGL, MSFT, NVDA, and TSLA is completely free. No API key needed. 46.7K GitHub stars. 8.1K forks. Actively maintained. 100% Open Source. MIT License.
207
My first @AlaskaAir flight with @Starlink onboard. super fast, low latency, nice. Thanks @TMobile !
67