Excited to announce @focalpointlp's "Human 3" thesis: the era of exponential human flourishing. While modern medicine (Human 2) benefited society in incalculable ways, it ultimately fell short of its promise because the available tools forced it to operate at an incremental pace with long feedback loops. Today, exponential technologies like AI - which can parse through terabytes of scientific literature and data in seconds - and brain-computer-interfaces, biosensors and CRISPR - which enable real-time, read-write access to our biology - promise to rapidly accelerate the scientific method flywheel and lead to an exponential explosion in health, wellness and performance. Human 3 will elevate every area of health and wellbeing, but will have the biggest impact in areas where modern medicine has made the least progress: the mental health crisis, neurodegeneration, chronic disease and aging. These are the “focal points” of our investment strategy. Human 3 is not a “sector” - our companies combine life sciences, AI, hardware, software, deep tech & health tech in novel ways that often defy conventional categorization. Human 3 is a philosophy of vitality. It is a knowing that the “user experience” of the human body and mind is long overdue for an upgrade. It is the willingness to build and invest in that future. This is Human 3. This movement marks the third great epoch of human health: - Human 1 was defined by medieval practices like bloodletting and humorism - medicine before evidence. - Human 2 was the era of “modern” medicine, which began in the 1850s when Louis Pasteur popularized the germ theory of disease and the scientific method became the gold standard. Human 2 was constrained by both incremental tools and artificial boundaries between disciplines. - Human 3 builds on Human 2’s legacy of scientific rigour, but is accelerated by exponential technologies, transdisciplinary collaborations, and driven by a belief that we can do so much more to not just heal the sick, but to prevent illness in the first place and elevate the already healthy. We’ve already backed some of Human 3’s genre-defining companies like @KernaLabs , @motifneuro, @Psylo_Bio, NeuroBionics, Kadence Bio, @superpower and Aperture Therapeutics, at their earliest stages. We’ve helped them secure pharma partnerships, hire their best talent and raise millions in follow-on financing and we’re just getting started. If you're a founder starting something in Human 3, we hope you'll consider working with @samalanascience and me.

> my wife and I stopped by Corgi Cafe on Friday night to check the hype > place was absolutely packed, there were two guys sitting nearly on top of each other in a phone booth because there were no seats > three women in total: the barista, my wife, and a girl who was trying to get work done but kept getting hit on by a guy in a suit who told he her owned the cafe ☠️

*rust developers in shambles*

being in Chicago for a few days has made me realize how insanely early we are in the GLP-1 adoption cycle

Fellas, I hate to be the bearer of bad news, but most girls don’t want a skinny peptide boy

A great look at @coherenceneuro, a company we've been backing since 2024. Coherence is actually building something useful for a real market; the thousands of people who get diagnosed with glioblastoma - one of the deadliest brain cancers - each year.

*hits invest button

Long

Irish Zionism

One of my favorite parts of being an atheist is that I don’t have to invent ways to excuse or downplay this type of depravity

Why don’t they just tokenize the oil in the Middle East and transport it across permissionless financial rails, thereby avoiding the Strait of Hormuz altogether

are there any peptides that can make your hog bigger? asking not for a friend

anyone working on time travel or teleportation? dm me

What's your favorite lunch spot in San Francisco, and who wants to eat there with me?

I love Swedes. I came to the hair salon. An angelic-looking Swedish girl was cutting my hair, and we were chatting about life, languages, travel, and emigration. At some point in the conversation, I had to mention that Russia had put me on its list of terrorists. The girl, excited: – Yaaay! That’s awesome!

bold email coming from a group that is hosting an upcoming conference on "neuro ethics" #EpsteinFiles

Attention Space 🚀 founders. I'm helping a new, stealth, space-focused VC fund set up meetings with pre-seed -> Series B founders. DM if interested!

Had a great time at the JPM Healthcare conference!

West Hollywood exists

If I don’t get a sick vintage car by the end of the Trump admin, I’m suing