Omics research at the intersection of molecular and computational sciences, led by @MartinAlexSmith@UNSWBABS leveraging all the hardware from @ramacgenomics
RNA is far more than a messenger.
Its structures regulate, evolve, and catalyze — carrying out functions DNA and proteins cannot alone.
But predicting #RNA structure from sequence is still extremely difficult.
In our latest NAR paper, we present a way forward.
🧵 ⤵️
Latest work from the lab: Genomic benchmarking strategies combined with interpretable machine learning reveal features that are important for improving #RNA structure prediction performance
Do long non-coding RNAs form conserved, functional secondary structures?🧬䷰𐂷 How can we systematically assess this?
We compared 2 tools fit for this task (SISSIz & R-scape) across 2 genomic benchmarking strategies.
Spoiler: machine learning wins (🧵/10)
biorxiv.org/content/10.1101/…
.@martinalexsmith was awarded the best talk for the Translational Award category at the #Zero Childhood Cancer National Symposium last May @KidsCancerInst
I'm recruiting a Postdoctoral Fellow for a 3-year academic level A appointment ($106K - $113K plus 17% superannuation and annual leave loading) to lead research projects in genomics & computational biology in stunning Sydney (🧵⬇️)
linkedin.com/jobs/view/39313…
Come say hi if you're at #LorneGenome @GenomeConf, poster #234. Ask me about nanopore direct RNA sequencing, long non-coding RNA function and pediatric leukemias.
Second poster (#149) from @therealsmithlab tonight at #LorneGenome @GenomeConf by @BiologistQuirky: A comparative benchmarking of conserved RNA secondary structure prediction tools for the systematic annotation of non-coding RNAs. Ask Vanda about R-scape, SISSIz & lncRNAs
Tonight at #LorneGenome @GenomeConf Poster 116, @AnshulStudiosus from @therealsmithlab:
Improving single cell transcriptomics with long reads. Ask Anshul about nanopore RNA-seq #bioinformatics benchmarking & discovery of cell-type specific lncRNAs
Very happy this is going out in Open Early Access!! It's been a labor of love for many involved! #RNA004 - higher accuracy & output, w/ more to come with the big RNA dorado release (v0.4.3) tinyurl.com/dorado-RNA. Mods, tails & more! See below for more info! @nanopore#directRNA
We will be soon be hiring a postdoctoral research officer (Level A) in Sydney to work on developing new applications for single-cell, single-molecule transcriptomics. Stay tuned.
We have received funding from @IVADO_Qc & @GenomeQuebec in collaboration with Dr Michael Chassé's team at @CRCHUM to explore the potential of real-time transcriptomic profiling in intensive care.
ivado.ca/en/2023/01/24/genom…
Nicholas Geoffrion has joined nanopore.ca@nanopore_ca to provide software engineering, data analysis and computational infrastructure support. He has lengthy experience integrating software solutions for genomics laboratories.
All @nanopore_ca services are maintained and will be managed through @CR_CHUSJ via a new Integrative Genomics platform, joining forces with experts from the single-cell sequencing core facility.
After over two years smashing out nanopore libraries and doing great research, @bulking_neuron has left the lab to join @nanopore as an Account Executive for Québec, Eastern Ontario and the Maritimes. Thanks for everything Bastien and we look forward to future collaboration 🧬
On recrute! Si vous connaissez quelqu'un qui serait possiblement intéressé de contribuer à l'implémentation de la génomique 🧬💻 unimoléculaire au Canada, 👇
linkedin.com/jobs/view/36586…