Gut microbes compensate for protein-deficient diets dlvr.it/TSzMYl

Researchers quantified associations between specific foods, broader dietary patterns and gut microbiome Find out more about diet-microbiome associations in 10,068 participants from the Human Phenotype Project @NatureMedicine  tinyurl.com/ms2s95jv

Dietary fat alters goblet cell function and microbial bile acid metabolism to promote intestinal lipid absorption in mice dlvr.it/TSz9qJ #MicroSky

This #GUTRecentAdvancesInBasicScience review synthesises emerging evidence linking the microbiome to cardiovascular disease, highlighting shared inflammatory and metabolic pathways. Fusco et al. present “Gut microbiota and atherosclerosis” - access it via bit.ly/48Lao7Y #GUTMicrobiota #Atherosclerosis @GiovanniCammar9 @gianluca1aniro

🧬CroCoDeEL is a new tool for detecting cross-sample contamination in metagenomic data.🐊🦠 The idea behind CroCoDeEL is simple and elegant. Imagine different cocktails poured into a row of glasses. If a drop from a Bloody Mary splashes into a Moscow Mule, the second glass gets a small, diluted but still recognizable trace of the first cocktail. CroCoDeEL looks for these suspicious “drops” in metagenomic profiles. In many ways, modern bioinformatics is the art of quality control. Samples from relatives — for example, a mother and her child — may naturally end up in neighboring wells on a plate. In that case, cross-contamination can be mistaken for microbiome heritability. The authors applied the tool to published datasets and found previously unnoticed contamination. In infant microbiome studies, some bacteria interpreted as possible mother-to-child transmission were likely contamination from maternal samples. This matters because such findings affect how we understand early microbiome development. Another example is the TwinsUK cohort, where CroCoDeEL identified 202 contaminated samples. Many shared the same sources, had higher species richness, and were more similar to each other than expected. nature.com/articles/s41467-0… #Microbiome #Metagenomics #Contamination #QC

See a brief review summarizing the use of synthetic microbial communities (SynComs) for revealing the ecology of specialized metabolites [my holiday break writing exercise] portlandpress.com/essaysbioc… [1/3]

Gut microbial diversity and inferred capacity to produce short-chain fatty acids are associated with acute stress reactivity in healthy adults The findings underscore the microbiota's potential to flexibly modulate human psychophysiology in stress: tinyurl.com/588x2cty

kuva v0.2.0 New plot types: Gantt, Network, Waffle, Horizon, PopulationPyramid, Joint, Clustermap, ROC, PR, Lollipop, Survival, Raincloud, Slope, Venn, Parallel, Mosaic, Streamgraph, Radar, Treemap, Sunburst, Bump, Funnel, Rose, Calendar, Legend, Text github.com/Psy-Fer/kuva

Prasad et al. present “Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach” via bit.ly/3QouXAU This work identifies a microbial metabolite linking intestinal dysfunction to retinal disease, offering both a biomarker and a potential therapeutic target. #DiabeticRetinopathy #Microbiota

Metformin, one of the most commonly prescribed drugs, was thought to work via the liver. Check that. It's primarily through the gut. @NatMetabolism nature.com/articles/s42255-0…

Is it time to include AI-based methods and approaches informed by the gut microbiome? @Elinav_Lab & colleagues update advances and opportunities @NatMetabolism  tinyurl.com/mvp6n7ys

New online! Next-generation probiotics: an outlook into current applications and future developments dlvr.it/TSRM6z

A microbiologist’s field guide to community ecology academic.oup.com/ismecommun/…

Genome-wide sweeps create ecological units in the human gut microbiome | Nature nature.com/articles/s41586-0…

A Bioinformatic Pipeline for Consensus Taxonomic Classification of Long-Read Amplicons biorxiv.org/content/10.64898…

The Diet–Microbiota–Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications mdpi.com/2072-6643/18/4/578

What happens to undigested protein in the gut? Super review of protein handling in the gut, and in particular in the colon. Read the full paper by @RobVBryant @Alice_APD nature.com/articles/s41575-0…

Dysbiosis in the skin microbiome is linked to dermatological diseases. This #ClinMicroRev article summarizes advances in understanding the composition and functions of the skin microbiome, its interaction with host immunity and impact on skin health. asm.social/2V8

A global group of 13 scientists and clinicians updates a consensus definition of gut health and implications from bench to bedside: tinyurl.com/ypehvcp9

Could microbial metabolites be potential biomarkers of sleep loss–associated health risks? Short-term sleep restriction in healthy humans alters 24-hour rhythmic profiles of microbially derived metabolites butyric acid and tryptophan @jclinicalinvest  tinyurl.com/3m4w4f6e