@mghmedres intern | prev @harvardMITmdphd @broadinstitute @macosko lab
Joined July 2012
- Tweets 97
- Following 295
- Followers 224
- Likes 828
1 Photos and videos
Tushar Kamath retweeted
May 12
Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.
With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…
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Tushar Kamath retweeted
Mar 2
2/8 Introducing Synapse-seq: our AAV-based tool for mapping brainwide presynaptic projections or postsynaptic distributions of molecularly-defined neurons, via protein-guided RNA barcoding & single-cell/spatial readouts: doi.org/10.64898/2026.02.26.…
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Tushar Kamath retweeted
3 Dec 2025
We are thrilled to have the following superstars join our fellowship program in July 2026. Congratulations to Erik, Wes, Tushar, Brian, May and Shawna, and congratulations to the MGH GI Division for recruiting such talent. Welcome to the family!
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19 Feb 2025
A truly impressive synthesis of bio-psycho-social!
19 Feb 2025
Excited to share new work from our team! Cognitive Behavioral Stress Management (CBSM) has been effective at reducing stress, and enhancing downstream neuroendocrine functioning, among women with breast cancer. But- this work has been in predominately high SES samples. @NGoelMD
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Tushar Kamath retweeted
12 Nov 2024
The first piece of work from my PhD has now been uploaded to biorXiv! Short 🧵below:
12 Nov 2024
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Tushar Kamath retweeted
7 Nov 2024
Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC
Led by the fantastic Hui Li, and co-supervised by @XihongLin
#ASHG24 poster 4089F
medrxiv.org/content/10.1101/…
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9 Jul 2024
A particularly exciting way to look at transcriptional data using lessons learned from statistical genetics!
8 Jul 2024
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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Tushar Kamath retweeted
8 Jul 2024
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
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7 May 2024
Exciting stuff from @LaylaSiraj @julirsch and friends!
6 May 2024
Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays!
biorxiv.org/content/10.1101/…
See below for a 🧵. 1/n
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29 Mar 2024
What a fantastic presenter at SCGD!
29 Mar 2024
Talk by @fluorocore on generalising single-cell analysis methods to spatial data #singlecellgenomicsday
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15 Mar 2024
Thrilled to have matched at @MGHMedicine in the Stanbury PSTP! Thanks to all my mentors, family, and friends for the support and love.
Thank you to all the patients who have taught me so much so far and the ones that I will learn from on my next journey!
Doctorin’ soon! 🩺🫡
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Tushar Kamath retweeted
13 Dec 2023
We now know the locations of cell types in a full mammalian brain.
Our work reveals the brainstem’s absolutely stunning cellular complexity. How and why does it arise?
Visit braincelldata.org to plot genes, localize types, and get markers.
nature.com/articles/s41586-0…
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Tushar Kamath retweeted
13 Dec 2023
Slide-tags unifies the single cell spatial genomics worlds. It solves three key problems with existing spatial methods:
1) Cell segmentation (the biggest problem)
2) robustness and scalability (well-powered case-control studies now possible)
3) Multiomics (ATAC, RNA, etc)
13 Dec 2023
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
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Tushar Kamath retweeted
30 Nov 2023
Excited to share the next chapter of primate genomics in @Nature, where we (@illumina, @IBE_Barcelona, and @bcmhouston) created a multiple sequence alignment of 239 primate species to better understand non-coding regulatory elements!
nature.com/articles/s41586-0…
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Tushar Kamath retweeted
22 Nov 2023
Excited to announce I will be starting my lab in @BIDMCpath @BIDMC_CancerCtr at @BIDMC . Using chemical genomic approaches and thorough biochemistry we will focus on revealing new mechanisms of metabolism regulated cell death with a special focus on metal (copper) biology.
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28 Sep 2023
Excited to share the final version of our manuscript detailing our work in understanding some of the earliest cellular changes in AD from brain biopsies of living individuals: cell.com/cell/fulltext/S0092…
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28 Sep 2023
A sentimental thanks to @macosko for all his support on what is likely the final contribution from my graduate thesis.
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28 Sep 2023
I remember @macosko describing this project to me in my first week as a graduate student -- awestruck both then and now, I am immensely grateful to all those patients who contributed their brain tissue while still alive (!) to our efforts to understand Alzheimer's disease.
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