Excited to share a preprint from my postdoc work in @seth_shipman’s lab!
We developed Detectrons — programmable biosensors that convert RNA signals into stable DNA barcodes inside living cells, enabling multiplexed RNA sensing. 🧵👇
biorxiv.org/content/10.64898…
Eugene Koonin @AudeBer discuss why some bacterial immune systems have no counterparts in eukaryotes, whereas a small subset of comparatively rare systems was co-opted as key elements of eukaryotic innate immunity 🦠🛡️🧍🏽♀️
🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research (1/8) biorxiv.org/content/10.1101/…
1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77
Our @MolecularCell Spotlight on the Hailong anti-phage system from the Kranzusch lab!
This defense uses "ssDNA tripwires" to trigger toxic ion channels 🧬⚡☠️
Fun write with Johannes Kühn!!
🧫 Save the Date!
We’re excited to announce an upcoming scientific seminar organised by our Early Career Team, with a spotlight on host–microbe crosstalk. Join us for a day of cutting-edge insights, discussion, and networking! Registration is open now - cphgut.ku.dk/events/seminar-…
OPEN CALL for PhD positions in our lab through the @semm_it program:
1️⃣ Microbiome signatures of early on-set colorectal cancer
2️⃣ High-resolution computational metagenomics for the study of human microbiome transmission
More info: semm.it/education/open-posit…
Apply by June 9!
Our new preprint, "Spatial constraints drive amylosome-mediated resistant starch degradation by Ruminococcus bromii in the human colon" is now on bioRxiv! Key findings in the thread below below biorxiv.org/content/10.1101/….
Our latest paper is out in science advances discussing cell division and morphogenesis control in S. aureus. Massive congratulations to Mariana and all of our other authors and collaborators!!
science.org/doi/10.1126/scia…
A large-scale literature review to which I contributed was recently published in Nature Medicine!!
"Clinical translation of microbiome research."
nature.com/articles/s41591-0…
If you are interested in phage satellites, we hope you'll enjoy this. Fun collaboration with the Rocha, Seed, Bikard, and Chen labs!
nature.com/articles/s41579-0…
I have been teaching classes on the gut #microbiome for almost 20 years and always struggled to have a good book to recommend. Finally there is one. Fergus Shanahan's "Fast Facts: The Gut Microbiome" provides expert insight, is brilliant, and it is free.
doi.org/10.1159/isbn.978-3-3…
Please spread the word! We have an opening in the Atkinson lab for a post-doc with a focus on molecular mechanisms of microbial immune systems. Can be a fully computational or experimental or hybrid project.
Read more & apply here:
lu.varbi.com/en/what:job/job…#phage#Bioinformatics