@willjnathan profile picture
William Nathan @willjnathan

Postdoc in the Nussenzweig lab at NCI/NIH | DPhil from @UniofOxford via @NIHOxCam interested in DNA repair, cancer, and aging

Joined November 2023
  • Tweets 9
  • Following 51
  • Followers 8
Photos and videos
William Nathan retweeted
Cell@CellCellPress
Jun 11
Now online! DNA repair drives cisplatin-induced neuronal death dlvr.it/TT03lc

DNA repair drives cisplatin-induced neuronal death

In neurons, cisplatin-induced DNA damage is repaired by NER, but low dNTP pools cause NER to promote death rather than survival. Deoxynucleoside supplementation or genetic upregulation of dNTP...

cell.com
9
27
3,555
Why does cisplatin treatment cause neurons to die? We identify that too much DNA repair exhausts the low level of dNTPs in neurons and drives cisplatin neurotoxicity. From @nussenza lab. Thanks to our many great collaborators on this work! Check it out: cell.com/cell/fulltext/S0092…

DNA repair drives cisplatin-induced neuronal death

In neurons, cisplatin-induced DNA damage is repaired by NER, but low dNTP pools cause NER to promote death rather than survival. Deoxynucleoside supplementation or genetic upregulation of dNTP...

cell.com
1
4
8
439
Implications of this work lies in reducing cisplatin-induced peripheral neuropathy, a harmful cisplatin side effect. Increasing dNTP levels is a potential strategy to reduce cisplatin side effects in the nervous system and possibly other post-mitotic tissues.
1
79
Ribonucleotide-associated indels in CTE! Unclear why ssIndels aren’t repaired…or maybe MMR/another pathway doesn’t know which strand is correct and sometimes creates the dsIndel. Cool study science.org/doi/10.1126/scie…

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to exposure to repetitive head impacts (RHI), yet little is known about its pathogenesis. Applying two single-cell...

science.org
50
Interesting. Curious to see the follow-ups showing what exactly CIRBP does in DSB repair. nature.com/articles/s41586-0…

Evidence for improved DNA repair in the long-lived bowhead whale

Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

nature.com
37
William Nathan retweeted
Shilatifard Lab
@ShilatifardLab
19 Dec 2024
My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik @bkcenik did it and here it is cell.com/molecular-cell/full… Not only was she able to develop this method, which she calls TurboCAS, she was able to identify known & novel regulators of heat shock & Myc expression. Cannot wait to see what Bercin and TurboCAS will discover about the molecular basis of transcriptional regulation with great impact on clinic in the next few years! @NU_BMG_SQE @NUFeinbergMed @MolecularCell
2:34
8
65
268
32,911
William Nathan retweeted
Cell@CellCellPress
17 Sep 2024
Now online! In vivo DNA replication dynamics unveil aging-dependent replication stress dlvr.it/TDMNkz

In vivo DNA replication dynamics unveil aging-dependent replication stress

In vivo DNA replication dynamics in regenerating mouse livers unveil aging-dependent decline in replication efficiency and a crucial role of the ATR checkpoint kinase in mitigating inflammation...

cell.com
27
86
14,074
William Nathan retweeted
nature
@Nature
24 Apr 2024
Nature research paper: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase go.nature.com/3UgWdj5

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Nature - VVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high...

nature.com
7
25
17,630
William Nathan retweeted
nature
@Nature
25 Apr 2024
Nature research paper: Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers go.nature.com/4dfngDV

2
12
57
27,710
Load more