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10 Apr 2024
The final version of our work on initiation-elongation transition by mammalian Pol II is now online! We visualized key transition steps during initiation and early elongation.
Many thanks to Patrick @mpgpresident, Christian @c_dienemann, Elisa @EOberbeckmann and the Cramer lab!
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Yumeng Zhan retweeted
14 Dec 2024
Preprint Alert! Check out our take on the molecular basis for co-transcriptional H3K36me3 deposition by SETD2. biorxiv.org/content/10.1101/…
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Yumeng Zhan retweeted
3 Apr 2024
Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. removal of Pol II from the DNA template
Published in @Nature
nature.com/articles/s41586-0…
Many thanks to my mentor Patrick Cramer @mpgpresident for unwavering support
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23 Dec 2023
Glad to share our new preprint on promoter escape by mammalian Pol II! We captured five transcription intermediates (de novo initiated from the PIC) and visualized the key steps where the initially transcribing complex (ITC) transitions into an elongation complex (EC).
23 Dec 2023
In vitro system for the initiation-elongation transition captures early events in RNA polymerase II transcription: @ymzhan, @c_dienemann et al., @EOberbeckmann et al. biorxiv.org/content/10.1101/…
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23 Dec 2023
Our work leads to a simple, three-step model of promoter escape by mammalian Pol II, which is regulated by RNA length, transcription bubble rewinding and elongation factors. Big thanks to Patrick @mpgpresident, Christian @c_dienemann, Elisa @EOberbeckmann and the Cramer lab!
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Yumeng Zhan retweeted
23 Dec 2023
In vitro system for the initiation-elongation transition captures early events in RNA polymerase II transcription: @ymzhan, @c_dienemann et al., @EOberbeckmann et al. biorxiv.org/content/10.1101/…
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