INFJ; Physician-Scientist; Plant dad 🌱
Joined March 2012
- Tweets 9,854
- Following 973
- Followers 1,812
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80 Photos and videos
Audacity MD retweeted
Having read the @gmcuk Outcomes for Graduates of Medical Schools, I suggest all UK Medical Students sit USA exams, USMLE. There's a serious danger UK Medical Qualifications might not be recognised outside UK - so little emphasis on Medical Knowledge & Expertise. @DrLKVaughan
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Audacity MD retweeted
Jun 8
Sit on any UK commuter train at 7:43am on a Monday and you'll see something that should be more uncomfortable than it is.
A carriage of adults in their thirties and forties, standing up shoulder to shoulder, headphones in, eyes locked on the floor or their phones, completely silent. Some of them have been doing this exact journey for 6, 8, 12 years.
Nobody is talking, nobody is making eye contact, and everyone has already rehearsed the next 12 hours in their head before the train has even left the station.
This is what the country quietly calls 'a good job in the city.'
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Jun 7
Nothing truly great or worthwhile has ever been achieved without enthusiasm.
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Can’t even remember the last time I touched cash
wait ppl actually rely only on apple pay and don't bring their physical cards with them🧍🏼♀️
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HLA sensitization poses major challenges to kidney transplantation. A new report describes transplantation in two highly sensitized candidates after desensitization with dual CAR T-cell therapy. Read the full report: nej.md/4forWeq
Correspondence: Kidney Transplantation after Clearing Anti-HLA Antibodies with CD19 CAR T Cells nej.md/4e1Gn5E
ALT The graph illustrates delisted anti-HLA antibodies levels over 450 days relative to CAR T-cell infusion. The x-axis represents days, while the y-axis shows mean fluorescence intensity. Three antibody types are tracked: HLA-A, HLA-B, and HLA-DR.
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In an African study of severe malaria in children with partially artemisinin-resistant parasites with PfK13 mutations, artesunate did not lead to worse outcomes, which suggests that parenteral artesunate may still be used. Full SMAART-CHARISMA study results: nej.md/4ejFV3X
ALT Green background with white text. A correspondence discusses malaria treatment, noting no link between ART-R parasites and worse clinical outcomes in patients treated with artesunate. It supports the continued use of parenteral artesunate as first-line therapy for severe malaria, even in settings with widespread ART-R. By K. Maitland et al., with a note to read the study in NEJM on intravenous artesunate in Uganda.
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Audacity MD retweeted
If your main criticism of a new cancer drug that doubles overall survival is “it’s not a cure”, please work on developing intellectually rigorous clinical trial assessments.
And while we’re at it, how about some empathy? An extra YEAR of life is nothing to balk at
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Audacity MD retweeted
I still think MDPI journals can have legit papers every now and then, but they are totally buried in a mountain of low-quality papers and terrible reviews.
Long story short, I avoid citing MDPI stuff in general because they ignore reviewers.
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Audacity MD retweeted
In January, I reviewed a Review for a crappy MDPI journal.
It was 100% AI, missing citations, etc. I sent a massive report, and the authors withdrew it.
Today, I see it published without a single change in another even crappier MDPI journal.
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Audacity MD retweeted
Immigrants from banned countries contributed nearly 24 000 physicians and 56 000 nurses to the US workforce in 2023, with higher presence in counties with workforce shortages and vulnerable populations.
#ARM26 @AcademyHealth
ja.ma/4u5s7Pd
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Audacity MD retweeted
Jun 1
As a non-oncologist, i feel quite comfortable jumping on the bandwagon here. I can count the number of times I've seen unsolvable problems in medicine get solved in my lifetime. No, this is not a cure, but there has been no greater challenge than pancreatic cancer. Nothing worked. Now this...
These results are simply spectacular
Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
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Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) nej.md/4nWaxvM
#ASCO26 | @ASCO
ALT A two-panel line graph shows overall survival in two populations, comparing darovasertib (blue line) and chemotherapy (gray line) treatments. Panel A depicts the RAS G12 population, while Panel B shows the overall population. Hazard ratios and confidence intervals are detailed in each panel.
ALT This image shows two line graphs titled "Progression-free Survival in the RAS G12 Population" and "Progression-free Survival in the Overall Population." Both graphs compare survival rates over 13 months between two groups: one receiving darovasertib and the other receiving chemotherapy. Accompanying the graphs are tables detailing the number of events and patients at risk for each treatment group.
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Audacity MD retweeted
Jun 1
An INCREDIBLE advance in pancreatic cancer. Compared to conventional treatment, Daraxonrasib, a new RAS inhibitor, was shown to increase survival in metastatic pancreatic cancer in this landmark NEJM trial:
> Median survival doubled
> 12-month survival tripled (18% to 53%)
> Less discontinuation (1.2% vs 11.2%)
Pancreatic cancer carries one of the worst prognosis - most cases carry a KRAS mutation which is targeted by this new class of treatment, bringing much needed hope to patients with this cancer, and potentially affecting other sites 🤞👏
nejm.org/doi/full/10.1056/NE…
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Audacity MD retweeted
Jun 1
RAS finally getting drugged is one of the great stories in modern biology, and almost nobody outside oncology understands why it's such a big deal.
YOU'LL LEARN SOMETHING AWESOME TODAY.
i am going to keep this as understandable (and simple) as i can.
OPEN THE THREAD.
🧵
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
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Audacity MD retweeted
May 28
Necessity is the mother of invention, or maybe the father in this case. 😂🥰
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Nature research paper: Universal transcriptomic hallmarks of mammalian ageing and mortality
go.nature.com/3PHno8u
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The US National Science Foundation (NSF) — a major funder of basic research — has restricted the flow of new research grants to a group of elite universities, Nature has learnt.
go.nature.com/4uMeoxS
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Audacity MD retweeted
May 27
Kaizen - A Japanese concept of continuous improvement.
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Audacity MD retweeted
May 26
University of California STEM professors want standardized tests back due to severe math deficiencies among students:
“We now observe preparation gaps so severe that instructors must reteach middle school mathematics”
“The current admissions metric, based primarily on GPA & essays, can no longer reliably distinguish readiness for university-level STEM majors in an era of severe grade inflation & AI assisted application essays”
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