Scientist, Entrepreneur, Dad, Teacher, Mentor. Tweets are personal opinions. bsky.app/profile/achemsynbio…
Joined November 2013
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49 Photos and videos
Abhishek Chatterjee retweeted
Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
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Chintan's @cpsoni_74 work demonstrating the efficient incorporation of non-α-amino acid backbones into proteins expressed in both E. coli and mammalian cells, just came out! A great collaborative effort from @cgem_cci! pubs.acs.org/doi/10.1021/jac…
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An accompanying paper from @AlannaSchepartz and Jamie Cate groups shows how the E. coli ribosome supports the incorporation of the non-α-amino acid monomers pubs.acs.org/doi/10.1021/jac…
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Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/…
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2 Oct 2025
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by @conor_loynd, @SinghaSoumya, and @SCanarelli! We introduce a new generation of BONCAT tools for versatile characterization of newly synthesized proteins in pathogenic bacteria rdcu.be/eI4M5
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Abhishek Chatterjee retweeted
24 Aug 2025
A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery dlvr.it/TMfgwR
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15 Sep 2025
Cool work from @Han_Xiao2016 on site-specific incorporation of an environment-sensitive fluorescent noncanonical amino acid to visualize protein microenvironment changes in living cells
15 Sep 2025
Genetically incorporating environment-sensitive noncanonical amino acids containing rotor-based fluorophores to target proteins enables real-time visualization of microenvironment changes in protein substructures
nature.com/articles/s41589-0…
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22 Aug 2025
Our work @cgem_cci on co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yielding novel backbone modifications. nature.com/articles/s41589-0…
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Abhishek Chatterjee retweeted
8 Aug 2025
Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research! science.org/doi/10.1126/scie…
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Abhishek Chatterjee retweeted
24 May 2025
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share!
youtube.com/watch?v=8YhJM6zx…
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Abhishek Chatterjee retweeted
15 May 2025
Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab.
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drive.google.com/file/d/1I-U…
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Abhishek Chatterjee retweeted
12 May 2025
Writing in @J_A_C_S, we report a sugar-derived single-addition monomer that can be added together with other monomers in #ROMP and install functional groups at the chain end of metathesis polymers. #glycotime #polymer #NSFfunded
pubs.acs.org/doi/10.1021/jac…
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NIH is centralizing peer review of all applications for grants, cooperative agreements and research and development contracts within the agency’s @CSRpeerreview. This is expected to save NIH more than $65 million annually & make the review process more efficient. go.nih.gov/iGmUyfH
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Abhishek Chatterjee retweeted
1 Mar 2025
This isn't science fiction. This is real sequencing biotechnology just introduced by Roche. Wild and wonderful.
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Abhishek Chatterjee retweeted
27 Feb 2025
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…
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Abhishek Chatterjee retweeted
25 Feb 2025
Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no role.
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Abhishek Chatterjee retweeted
15 Feb 2025
1/ After residency at Mass General Hospital, I reported to Atlanta to meet my fellow CDC Epidemic Intelligence Service Officers.
I have never felt so intimidated by my peers
The best and the brightest, they were star clinicians, had served in disaster zones; MD/PhDs and MSF.
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12 Feb 2025
Thrilled (and relieved) to finally have this review by Arianna, Zeyi, and Kaitlyn out! Everything you've ever wanted to know about genetic code expansion in mammalian cells! pubs.acs.org/doi/10.1021/acs…
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