Researching skeletal development, repair, and neoplasia @JohnsHopkins. BST Pathologist @JHUPath.
Joined June 2017
- Tweets 375
- Following 622
- Followers 602
- Likes 1,026
42 Photos and videos
Excited to share our recent paper in @ScienceTM ! We highlight tendon-associated sensory nerves are not only pain-transmitting fibers, but also protective regulators of tendinopathic changes through FGF1 signaling. Thanks @AaronWJames_Lab. Check it out : science.org/doi/full/10.1126…
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Congratulations to first author Dr. Manyu Zhu and team for their work in @ScienceTM 👏👏 Showing for the 1st time that sensory nerves protect against tendon degeneration! Work done @JohnsHopkins @JHUPath
science.org/doi/10.1126/scit…
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James Laboratory retweeted
#Hemophilia patients lacking Factor VIII face hidden bone loss, not just bleeding. Replacing this clotting protein restores #bone density, expanding hemophilia care from stopping bleeds to protecting #skeletal health.😀
@BoneRes_Office
nature.com/articles/s41413-0…
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James Laboratory retweeted
Unwanted #bone growth in soft tissues after #trauma is driven by a protein switch called #PRMT6 that amplifies #inflammation. Targeting it early could prevent this disabling condition while preserving normal tissue repair, offering a precision therapy for injury patients.👇
@BoneRes_Office
nature.com/articles/s41413-0…
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James Laboratory retweeted
The #spine contains a newly discovered network of lymphatic #vessels that drain brain fluid and control #inflammation. Rewriting long-held anatomy beliefs, this hidden pathway could unlock targeted therapies for #spinal diseases, #nerve damage, and chronic back pain.🥳
@BoneRes_Office
nature.com/articles/s41413-0…
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Congrats to Zhao Li and team for their work out today. 👏 👏 Hedgehog signaling implicated in nerve-directed calvarial bone healing! See results here. Work performed at @JohnsHopkins @JHUPath ⬇️ ⬇️ ⬇️
pubmed.ncbi.nlm.nih.gov/4200…
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James Laboratory retweeted
After menopause, bone-breaking cells become overactive because they get coated with sugar molecules. Stripping off this sugar could stop bone loss as effectively as estrogen but without hormone therapy's risks.👇
#menopause #bone #hormone
@BoneRes_Office
nature.com/articles/s41413-0…
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James Laboratory retweeted
Long-term steroid use destroys hip joints by blocking blood flow and killing bone tissue. Understanding these cellular mechanisms offers targets for early intervention and prevention, potentially sparing patients from debilitating joint collapse and replacement surgery.😀
#steroid #bone #joint
@BoneRes_Office
nature.com/articles/s41413-0…
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James Laboratory retweeted
Bone cells sense how stiff their surroundings are through their microtubule skeleton, directing cell division. This reveals how physical forces guide cartilage repair, pointing to new treatments for joint injuries and osteoarthritis.🧐
#bone #osteoarthritis
@BoneRes_Office
nature.com/articles/s41413-0…
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Love this. As the year progresses we are looking for new and talented trainees! Happy to meet potential lab members interested in skeletal neuroscience @ORSsociety meeting #ORS2026
Quiet motivation, pushing you forward into the year ahead.
Happy New Year from the James laboratory @AaronWJames_Lab ✨
#Science #Research #AcademicLife #HappyNewYear2026
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James Laboratory retweeted
Quiet motivation, pushing you forward into the year ahead.
Happy New Year from the James laboratory @AaronWJames_Lab ✨
#Science #Research #AcademicLife #HappyNewYear2026
31 Dec 2025
Walking the halls at work, and am so grateful for all lab members (past and present) that helped with our recent achievements. Happy new year and may 2026 bring new knowledge and new journal covers! Photo taken @JHUPath @JohnsHopkins @HopkinsMedicine
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James Laboratory retweeted
A bone-strengthening hormone (PTH) relieves chronic back pain by reversing spinal bone thickening and blocking painful nerve growth. This suggests repurposing an existing osteoporosis drug to treat age-related spine degeneration in humans.🧐
#PTH #bone #osteoporosis
@BoneRes_Office
nature.com/articles/s41413-0…
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James Laboratory retweeted
Lymphatic vessels in bones and joints drive arthritis and fracture progression. Targeting lymphatic vessels could speed healing and reduce inflammation—offering new drug targets for common musculoskeletal disorders.🥳
#musculoskeletal #bone
@BoneRes_Office
nature.com/articles/s41413-0…
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James Laboratory retweeted
Nerve signals help heal bones by calming inflammation. Spicy food or a pain-relief cream boosts this process, offering new ways to treat bone diseases.👍
#bone #nerve
@BoneRes_Office
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James Laboratory retweeted
Feb 27
NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true.
Here is a graph showing how many fewer new funding opportunities that NIH has posted over time.
-91%, a trend that started on Jan 2025.
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It's that time of year! Hiring in the James lab. Please join this stellar group to lead our next effort! Most recent pub here 🔽🔽🔽👇👇👇 science.org/doi/10.1126/scie…
Work @JHUPath @HopkinsMedicine @JohnsHopkins
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#FGF9 Adhesive Capsulitis
cytoHubba➡️FGF9 as an AC hub gene
FGF9 ⬆️in 👤AC glenohumeral joint capsule & 🐭Shoulder Stiffness (joint immobilization)
Which cell type?🧐
Where is FGF9 Ab info?😳
FGF9 ⏫NIH3T3 fibroblast proliferation migration & α-SMA level in a PI3K-dependent manner
@FrontCellDevBio 2025
frontiersin.org/journals/cel…
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Our paper published in Science! Big congrats to @AaronWJames_Lab 🎉!Check it out: science.org/eprint/ITYHFUNWC….
So grateful to our team for their tireless efforts and this culmination. A wonderful way to begin the new year! Work done @JohnsHopkins @JHUPath and published in @ScienceMagazine
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#SpatialTranscriptomics
Visium @10xGenomics
Vascular SpatialTime
CD201/PROCR human perivascular mesenchymal progenitors
Located at the outer adventitia of artery/vein in adipose tissue
Wnt-hi
A potential hierarchy of adventitial CD34 CD31-CD45-CD146- cell progenitorness
CD201➡️CD304/NRP1 or CD141/THBD
@NThottappillil @AaronWJames_Lab @Dev_Cell 2024
cell.com/developmental-cell/…
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