Proud to see this world wide effort for #DSP finally out! Kudos to my DSP-erados partner @RTCarrick for bringing this paper home and thanks to the many collaborators @ProtonotariosA @HughCalkinsMD @LaredoMikael @AdamHelmsMD @vnparikh @jpvantintelen @teRieleA @JuliaCTourigny

#OriginalResearch In mice models, dysfunction adhesion was demonstrated to play a key role in the pathophysiology of arrhythmogenic cardiomyopathy #AHAJournals ahajrnls.org/3Nyu57q

Like everything else she writes, a must read in @JACCJournals #JACCHF from @AG_EM33 💙💚 Critical Importance of Genetic Screening in Family Members #cvGenetics jacc.org/doi/epdf/10.1016/j.…

Outstanding @jclinicalinvest review about novel myosin-based interventions! @jct_ucb @sday_hcm JCI - Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure jci.org/articles/view/148557…

Excited to share some new work from us today on ultra-rapid genome sequencing for the diagnosis of critically ill children and adults. In critical care settings, genetic diagnosis can shorten stays, direct precision therapy, save money, and help with family planning. 1/

In this randomized phase 2 trial, Valsartan improved cardiac structure and function in patients with early-stage sarcomeric HCM compared to placebo. @NatureMedicine @glimongelli @Fedeilardi @FGraziani_Grace @IacopoOlivotto @saramoscatelli7 @PeroneFrancesco nature.com/articles/s41591-0…

Excited to share our work on iPSC-derived 2D cardiac muscle bundles. Accessible and reproducible contractile assessment, insights on cardiac development, disease modeling. Read @NatureComms rdcu.be/cz3pD @BakerLaboratory @LoriLIsom1 @yuweiwu_imb @umichCVC

Super excited to release genebass.org, a web application for browsing association results for 3,700 phenotypes across 281,850 individuals from the UK Biobank. The site features plots, tables, and controls for exploring billions of associations.

Our paper on “The genetic architecture of Plakophilin 2 cardiomyopathy” is now online at @GIMJournal. Please check it out (and/or read the thread below) at rdcu.be/cmqCE ! 1/n

Our work in childhood-onset HCM now published in #EHJ @ESC_Journals Take Home Points: 1) 3 peaks of HCM onset, peak in teens driven by Sarcomeric HCM 2) ~15% of HCM is diagnosed in childhood, carrying ~2%/yr event rate 3)⬆️risk of VT & VAD/Transplant compared to adult-onset

⚡Out today from @ChrisMHaggerty team: Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy through Genomic Screening of Pathogenic Desmosome Gene Variants ahajournals.org/doi/abs/10.1… @AHAScience #ahajournals #cardiogen 📽️@JeanetteErdmann @AnwarChahal

EXPLORER-HCM CMR substudy finds that mavacamten favorably impacts cardiac structure in obstructive HCM. Read more: ow.ly/Iobx50DxLH0 #AHAJournals @S2beri

Grateful to work with @EricSmithMD & outstanding collaborators incl @neallakdawala @DanielJacobyMD @emmcnally @LWilsbacher @AubertGregory. Great to see recurring themes in others just out @piriou_nicolas et al @ESC_Journals, Poller et al @JAHA_AHA, Gandjbakhch et al @Circ_Gen