Condensins are enriched at promoter regions in mitosis in many eukaryotes. So, does transcription factor into mitotic chromosome condensation? Check out our new work @elife doi.org/10.7554/eLife.75475

It was wonderful to be part of the group honoring the memory and contributions of David Allis and Gary Felsenfeld to the field of chromatin biology and epigenetics at the National Cancer Institute. @theNCI Thanks to Shiv Grewal @grewalsh, and the organizing committee at NCI for putting this outstanding meeting together. @NIH @NUFeinbergMed @NorthwesternMed @LurieCancer @DrBrianStrahl @MuirLab @berger_lab @CKadoch @GAlmouzni @bernstein_lab @AsifaAkhtar1 @YiZhang_Lab @senergystic @todd_macfarlan @NogalesLab @pioneerfactors @PeterLewisLab @PlathLab @AlexKellyLab

Hurry! The deadline to register for the exciting symposium on "Histone Modifications and Chromosome Structures" is quickly approaching—this Friday, October 4, 2024. This symposium featuring talks by 25 renowned scientists is free to attend. To secure your spot, please visit: go.cancer.gov/hrxQPuE

🎉 Exciting Announcement! 🎉 “Histone Modifications and Chromatin Structure Symposium” 🗓️ Dates: October 17-18, 2024 📍 Location: National Institutes of Health, Bethesda, Maryland The NCI Center of Excellence in Chromosome Biology is delighted to invite you to our upcoming symposium. This symposium honors the legacies of Dr. C. David Allis and Dr. Gary Felsenfeld, pioneers in the study of chromatin and gene expression. Presentations from 25 renowned scientists. For more details and to register, visit: ncifrederick.cancer.gov/even…

Happy to share our work about DNA supercoiling, an understudied physical feature of the double helix and the chromatin. 1/5 nature.com/articles/s41594-0…

📢ACCESS DENIED!! Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited? Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance #epigenetics #heterochromatin #histones #chromatin Congratulations to @rakesh_k_sahu and other lab members! cell.com/molecular-cell/full…

We're deeply saddened by the passing of Dr. Maxine Singer, esteemed scientist emeritus at NCI’s Laboratory of Biochemistry and Molecular Biology. Her groundbreaking work and dedication to science have left an enduring legacy. Our thoughts are with her family and colleagues🌹

Comprehensive cancer survivor care is essential. Learn more about the latest here:

Preprint🚨on a new mechanism of genetic cheating in meiosis! 🧬We found that a mouse selfish DNA, R2d2, combines the elements of both male and female meiotic drivers! (gamete sabotaging in female meiosis) biorxiv.org/content/10.1101/…

My department is hiring! Tenure track faculty position in genetics. Researchers using any eukaryotic model, including fungi and plants are encouraged to apply! We are a broad biology department with strengths across all kingdoms. Join us! Apply by March 1 tinyurl.com/y4evds8p

Our department is looking for a computational biologist. Please help spread the word!

📢An elegant dance between replication and histone retention for epigenetic inheritance!🥳Our new work shows that heterochromatin domains are specialized replication zones that preserve parental modified histones to ensure self-templated chromatin assembly bit.ly/4b8wpNA

Now recruiting: enthusiastic postdocs to use advanced imaging methods to dissect biological processes. My group at Harvard has 2 Wellcome-funded positions examining the underlying mechanisms and resultant forces driving bacterial growth, division, and antimicrobial resistance.

Huge thanks to @chienlab @UMassBMB and @UMassMCB for hosting me at the MCB seminar series yesterday! @UMassAmherst has a great community and wonderful trainees, I really enjoyed all of my discussions!

Congratulations Joana and team!

Our first research paper is now published at nature! 🎉🐭🔬We found that F1 hybrid female mice can have defective chromosome condensation in oocytes, creating a reproductive isolating barrier. Congrats again to our postdoc, Warif El Yakoubi🎊 nature.com/articles/s41586-0…

Congratulations to Tom Misteli of the National Cancer Institute on winning ASCB’s 2023 E.B. Wilson Medal--presented at #cellbio2023 to distinguished researchers for their far-reaching contributions to cell biology over a lifetime in science. @NCITomMisteli @theNCI

Can we amplify RNA without reverse transcription to cDNA? Based on the finding that ssRNA template can be directly amplified by T7 in vitro transcription, we invented LAST-seq for RT-free single-cell RNA sequencing, offering a high capture efficiency. genomebiology.biomedcentral.…

On Thursday, I’m giving an @NHGRI intramural seminar: Genetic conflicts during meiosis shape the rapid evolution of essential chromatin proteins; work of @ChingHoChang Aida de la Cruz, & Emily Coelho among others genome.gov/event-calendar/NH…

Kinetochore community save the date! The 8th EMBO Dynamic Kinetochore Workshop will happen from 17–20 June 2024 at Caux in Switzerland. Sign up for notifications at coming-soon.embo.org/w24-37 - the full website will be launched in September. #EMBOkinetochore2024 #DKW2024

New paper alert! What controls where and how a cell builds a kinetochore? Turns out you don’t complex regulation or even DNA. Simply bringing together a single protein at a high local concentration is sufficient to trigger robust kinetochore formation. biorxiv.org/content/10.1101/…