Joined March 2016
- Tweets 73
- Following 126
- Followers 132
- Likes 337
1 Photos and videos
Alex Pollatos retweeted
Decagram-scale synthesis of dibenzopentalenes ✔ Late-stage modification ✔ Short and efficient synthetic routes for functional organic materials ✔ @RSCAdvances @marcellbogner doi.org/10.1039/D6RA03886G
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If you've noticed electrochemistry showing up in more and more total syntheses, our new review is for you! Electrosynthesis has been around for decades, but its role has only recently taken off – we cover how it went from niche tool to go-to strategy.
Jun 2
Electrochemistry Goes Mainstream: Applications in Modern Total Synthesis, a review appearing today in @ChemRxiv :chemrxiv.org/doi/full/10.264…
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Alex Pollatos retweeted
5 Nov 2024
Thrilled to share our new preprint in @ChemRxiv, in which we unveil a new avenue to access valuable scaffolds for drug development that were previously virtually inaccessible. Huge thanks to all our collaborators for making this work possible!
5 Nov 2024
Triply Convergent Ni-Electrocatalytic Assembly of 1,1-diaryl Cyclobutanes, Azetidines, and Oxetanes, appearing today in @ChemRxiv :chemrxiv.org/engage/chemrxiv…
Increasingly complex, three-dimensional leads for drug discovery are testing the limits of modern organic synthesis. In this context, the need for new methods to access gem-diarylated cyclobutanes, azetidines, and oxetanes is apparent. The present study outlines a modular, scalable, chemoselective approach to solve this problem using simple alpha-bromoacids and aryl halides as intuitive starting materials. As demonstrated herein, a sequential series of Ni- electrocatalytic cross-couplings can be enlisted to enable rapid access to such structures, many of which have never been accessible before, without recourse to time-consuming polar bond disconnections that are inherently limiting in terms of accessible chemical space. The scalability of this new reaction sequence is demonstrated, alongside direct applications to known patented structures. A simple user guide is also presented to accelerate adoption of this strategy in medicinal chemistry.
A super fun collaboration with BMS, Pfizer, Biogen, Enamine, and Abbvie.
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Alex Pollatos retweeted
29 Jul 2024
The final version of this work has appeared today in @J_A_C_S
A General Three-Component Alkyl Petasis Boron–Mannich Reaction | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
14 Mar 2024
Now you can Petasis (virtually) any borons! Super simple and powerful method to prep fully-sp3 complex amines is now on @ChemRxiv as our collaborative work with @QinLab. Congrats on everyone's accomplishment! @JetTsien @SijieChen17 @rohanmerchant1
go.shr.lc/48Usx0t
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Alex Pollatos retweeted
30 Apr 2024
Chemistry is puzzling over a boc group that survived 4 M HCl/Dioxane overnight
29 Apr 2024
Mathematics is finding interesting puzzles and solving them
Physics is looking at the solution to the most interesting puzzle there ever was and trying to figure out how nature did it
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Alex Pollatos retweeted
2 Apr 2024
#TotalSynthesis of Dragocins A-C through Electrochemical Cyclization (Phil S. Baran and co-workers) @BaranLabReads onlinelibrary.wiley.com/doi/…
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Alex Pollatos retweeted
2 Feb 2024
Thrilled to summarize our bioinspired skeletal reorganization approach for the synthesis of steroid natural products in Acc. Chem. Res. Credit to @yuwang175 for writing this Account. Big thanks to members of my team for their great contributions: bit.ly/484VW7A
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3 Jan 2024
Thrilled to have played a role in the implementation of electrochemistry in this beautiful synthesis! Pleasure to work alongside my friends and colleagues Brendyn, Nate, and @AlbertoFGC
3 Jan 2024
⚡️An electrifying total synthesis to start 2024⚡️! The total synthesis of Dragocins A-C appearing today in @ChemRxiv: chemrxiv.org/engage/chemrxiv… . Happy New Year! 🥂
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Alex Pollatos retweeted
25 Oct 2023
Our work on scaling electrochemistry via constant potential is out. Give it a look
A Scalable Solution to Constant Potential Flow Electrochemistry | ChemRxiv - go.shr.lc/3SduoJ9
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27 Sep 2023
Love me a good peptide! Congrats to Fabian and the team!!
26 Sep 2023
ONE (aziridine) RING TO RULE THEM ALL! The total synthesis of Dynobactin A, appearing today in @ChemRxiv: chemrxiv.org/engage/chemrxiv…
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24 Aug 2023
A tour de force! Congrats to @ManoliSofiadis , @Dongmin_Xu , and Anthony on conquering the κύκλωπας!
23 Aug 2023
CYCLOPAMINE! A total synthesis with LEO Pharma collaborators. Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
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Alex Pollatos retweeted
25 Jul 2023
"Dump, stir, electrify" - Quaternary centers made easily through decarboxylative arylation of tertiary acids with (hetero)aryl bromides. Appearing today in @ChemRxiv: tinyurl.com/ybtbaa5s. A super fun collaboration with BMS, Biogen, LEO Pharma, and Enamine.
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Alex Pollatos retweeted
17 May 2023
Happy to share on ChemRxiv our stereoselective synthesis of (–)-eugenial C via MHAT/SH2 iron catalysis. tinyurl.com/578mp2d8
It took trial and error, rational design and even a little citizen science to locally source our starting material (thanks @SDNHM Plant Atlas!!).
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Alex Pollatos retweeted
11 Apr 2023
A significant step toward the biomimetic synthesis of vancomycin and other glycopeptide antibiotics.
In our new @chemRxiv preprint, we present a selective multicopper(II) cluster-catalyzed oxidative phenol macrocyclization (OxPM) of linear peptides.
doi.org/10.26434/chemrxiv-20…
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23 Feb 2023
So many nitrogens it's almost energetic!
Congrats Cheng! Truly a piece of art
23 Feb 2023
Got Nitrogen? A concise enantioselective synthesis of the marine-derived alkaloid KB343 is disclosed today in @ChemRxiv: bit.ly/3SoRMkQ.
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Alex Pollatos retweeted
19 Jan 2023
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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19 Oct 2022
Samer is a rising star!! Snatch up these positions while they're available!
#POTC
19 Oct 2022
The Gnaim Lab website is up! s-labs.webflow.io/
We are building up a chemistry lab @WeizmannScience situated at the interface of reaction discovery, electrosynthesis, and catalysis.
Interested in joining us? Check out the website for open positions
#chemjobber #realtimechem
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Alex Pollatos retweeted
16 Jul 2022
My unpopular opinion: If we make talking to strangers (as adults) culturally taboo, the only strangers who will talk to people are assholes and that will make us think that everyone is an asshole and that is bad, so I think striking up conversations with strangers is very good.
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