PhD Student @mpi_nat @CramerLab, interested in structural biology and climate crisis, opinions are my own
Joined March 2021
- Tweets 44
- Following 354
- Followers 179
- Likes 22,803
Photos and videos
Pinned Tweet
13 Aug 2024
Thrilled to share our new preprint on the molecular mechanism of influenza virus cap-snatching! 🦠🧬
biorxiv.org/content/10.1101/…
We determined structures showing how flu polymerase hijacks host RNA polymerase II to steal RNA caps, a crucial step in viral gene expression.
7
23
78
10,306
A research team from the Max Planck Institute for Multidisciplinary Sciences, Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate.
Check out the MPI press release: mpinat.mpg.de/5179649/pr_260…
14
62
4,826
Alexander Rotsch retweeted
8 Jan 2025
Structure of the Nipah virus polymerase complex
Jonathan Grimes and collaborators
embopress.org/doi/full/10.10…
6
12
2,077
Alexander Rotsch retweeted
17 Dec 2024
Perfect holiday reading! Dive into the exciting work on the molecular mechanism of co-transcriptional H3K36me3 by SETD2 from our fantastic postdoc @sciJamesWalshe & Moritz Ochmann! biorxiv.org/content/10.1101/…. Also check out the great related work by @LucasFarnung & @KurumizakaLab.
10
32
3,100
Alexander Rotsch retweeted
6 Dec 2024
The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/shor… (1/6)🧵
2
4
16
2,386
Alexander Rotsch retweeted
21 Nov 2024
So proud of Dr Aitu @zhnbkv_ai!! Congratulations on her fantastic PhD 🎉
1
2
26
5,720
Alexander Rotsch retweeted
6 Nov 2024
We had a great time at our lab retreat at the Harnack House together with the @MariekeOudelaar lab and @mpgpresident. Exciting talks from our guest speakers Stephan Hamperl, @EddaGSchulz and @S_Grosswendt. Thanks for coming!
4
27
2,973
Alexander Rotsch retweeted
30 Oct 2024
The pro-Trump "free speech enthusiast" owner of this platform decided to just delete the viral anti-Trump ad I posted I few days ago (and replaced it with a "This Post was deleted by the Post author" message).
So here it is again Elon, enjoy!
199
7,615
25,730
1,234,512
Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem
👇👇👇
4
51
216
34,206
Alexander Rotsch retweeted
26 Aug 2024
Congratulations to Florian Kabinger and Alexander Rotsch for passing their PhD defenses today with distinction. @FKabinger @AlexanderRotsch
1
1
74
3,647
Alexander Rotsch retweeted
13 Aug 2024
Deadly kiss of polymerases: How Influenza polymerase cleaves capped nascent RNA from host Pol II to start its own transcription. Preprint from Alexander Rotsch et al. with Steven Cusack‘s lab @EMBLGrenoble.
biorxiv.org/content/10.1101/…
12
88
6,438
13 Aug 2024
Thrilled to share our new preprint on the molecular mechanism of influenza virus cap-snatching! 🦠🧬
biorxiv.org/content/10.1101/…
We determined structures showing how flu polymerase hijacks host RNA polymerase II to steal RNA caps, a crucial step in viral gene expression.
7
23
78
10,306
13 Aug 2024
Huge thanks to all co-authors! This work was a team effort, combining expertise in structural biology, biochemistry, and virology. Special shoutout to Delong Li, Maud Dupont, @krischuns, @MariaLukarska @isaac_fianu, @c_dienemann, Nadia Naffakh, Stephen Cusack and @mpgpresident.
4
311
13 Aug 2024
3. We captured structures before and after RNA cleavage, revealing how the cleaved capped RNA fragment is positioned for immediate initiation of viral transcription. This provides a complete structural view of the cap-snatching mechanism.
1
229
13 Aug 2024
🔬 Key findings:
1. We identified the minimal host complex required for efficient cap-snatching is an elongating Pol II complex with DSIF.
2. Cryo-EM structures reveal precise molecular interactions between flu polymerase and host machinery.
1
233
13 Aug 2024
Cap-snatching is essential for flu virus replication. The virus steals caps from host mRNAs to make its own transcripts stable and translatable. Understanding this process at the molecular level is crucial for understanding influenza infection.
3
408
Alexander Rotsch retweeted
22 May 2024
Es geht wieder los: Die Aufgaben zur 1. Runde der IBO 2025 stehen für euch bereit! Diesmal geht es um Honigbienen🐝, die Backhefe S. cerevisiae in der Biotechnologie🧑🔬, Organspende🫀 und das menschliche Gedächtnis 🧠. Klingt spannend? Dann erfahrt mehr auf biologieolympiade.info
2
4
241
Alexander Rotsch retweeted
12 Jun 2024
Extremely honoured to receive the Otto Hahn Medal and the Otto Hahn Award today from the Max Planck Society @maxplanckpress ! An amazing recognition of my work and the scientific environment and support in the @SchuhLab at the @mpi_nat ! 🔬❤️
27
10
270
28,612
Alexander Rotsch retweeted
24 May 2024
I’m happy to announce that I was appointed a junior professor at @yourUMG. Many thanks to everyone who supported me during my journey, especially @mpgpresident and his team (@lidschreiber, @c_dienemann & K. Zumer), but also all past and present colleagues and collaborators.
14
1
54
5,703
Alexander Rotsch retweeted
10 Apr 2024
The final version of our work on initiation-elongation transition by mammalian Pol II is now online! We visualized key transition steps during initiation and early elongation.
Many thanks to Patrick @mpgpresident, Christian @c_dienemann, Elisa @EOberbeckmann and the Cramer lab!
7
16
3,469
Alexander Rotsch retweeted
3 Apr 2024
Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. removal of Pol II from the DNA template
Published in @Nature
nature.com/articles/s41586-0…
Many thanks to my mentor Patrick Cramer @mpgpresident for unwavering support
30
39
215
38,473