MD PhD Professor @HarvardMed @BrighamWomens @broadinstitute | membrane proteins and disrupted homeostasis in kidney, metabolic, degenerative genetic diseases
Joined October 2015
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3 Jul 2025
Delighted to share our latest, expertly led by @KatlynGabriel_ and @ChoahK:
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
Impactful work with therapeutic potential by our @GrekaLab team at @broadinstitute!
science.org/doi/10.1126/scia…
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10 Mar 2025
Thank you @EricTopol for this vital conversation about untapped opportunities in this pivotal moment for biomedicine.
9 Mar 2025
Research support for rare diseases, which cumulatively affect ~30 million Americans, is primarily derived from NIH.
Such work is exemplified by @AnnaGreka @broadinstitute in a new Ground Truths podcast.
Open-access, w/ transcript, full video, no ads
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Flushing out misfolded uromodulin as a treatment concept for kidney proteinopathies: jci.org/articles/view/180347
ASCI member @AnnaGreka & team @harvardmed restored uromodulin localization in models of autosomal dominant tubulointerstitial kidney disease using a TMED-targeting small molecule.
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Anna Greka retweeted
26 Sep 2024
Taking place tomorrow 👇🧬🩺💊💉👨💻👩💻 @broadinstitute @AnnaGreka #genomics #biology #AI #medicine 🧐 eventbrite.com/e/connecting-…
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20 Sep 2024
Delighted to share our latest @GrekaLab story in collaboration with @WuLabHarvard on the molecular basis of TMED9 cargo receptor oligomerization and entrapment of misfolded cargo in the early secretory pathway. @broadinstitute @harvardmed @MassGenBrigham
science.org/doi/10.1126/scia…
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Anna Greka retweeted
25 Jun 2024
Studies in mice suggest that strategies to enhance kidney TREM2 high macrophages may provide therapeutic benefits for DKD #diabetes #kidneydisease @CellReports cell.com/cell-reports/fullte…
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Anna Greka retweeted
23 May 2024
Our work describing #TREM2 #macrophages in #obesity & #diabetes-associated #KidneyDisease is out. An exciting journey since first sighting #TREM2 macs in our kidney #scRNAseq in 2018 w Yiming, Katherine @AnnaGreka @broadinstitute Huge 🙏🙏 to all coauthors dlvr.it/T7FFMb
2 Jun 2021
Excited to share the results of a huge collaborative effort @broadinstitute @brighamWomens providing comparative cellular taxonomies of human and mouse adult kidneys using #scRNAseq . We studied the healthy, obese & diabetic kidney to ID shared cell states across species 1/
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23 May 2024
Our latest out today in @CellReports
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Congratulations to @ayshwaryas Yiming Zhou, Katherine Vernon, a great group of co-authors @Zimmermk1986 @ClatworthyLab Aviv Regev and many other amazing collaborators. Grateful to @humancellatlas and @cziscience for their support!
22 May 2024
Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury dlvr.it/T7FFMb
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Anna Greka retweeted
22 May 2024
Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury dlvr.it/T7FFMb
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Anna Greka retweeted
1 Mar 2024
#RareDiseaseDay2024
@GrekaLab @harvardmed @BrighamResearch
Thank you @TEDTalks for the opportunity to share this idea with the world!
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4 Oct 2023
"The amazing thing about science is that if you follow your curiosity, it can lead you to untold scientific treasures" - @AnnaGreka
Watch Dr. Greka's TED Talk to learn more about her work and the impact it can have on millions of people globally.
ted.com/talks/anna_greka_the…
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Anna Greka retweeted
4 Oct 2023
"The amazing thing about science is that if you follow your curiosity, it can lead you to untold scientific treasures" - @AnnaGreka
Watch Dr. Greka's TED Talk to learn more about her work and the impact it can have on millions of people globally.
ted.com/talks/anna_greka_the…
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Anna Greka retweeted
29 Sep 2023
Congratulations @AnnaGreka on the fantastic @TEDTalks! Hear from Anna on "The world's rarest diseases — and how they impact everyone." ted.com/talks/anna_greka_the… @GrekaLab
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17 Jul 2023
Nearly 600 colleagues have registered for our #LaddersToCures Symposium @broadinstitute tomorrow! Come hear from innovators and leaders from @BostonChildrens @HHMINEWS @harvardmed @MassGeneralNews @IAmBiotech @GlobalGenes @MassBio
broad.io/l2c
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Anna Greka retweeted
11 Jul 2023
Join us on Tuesday, July 18 for the inaugural Ladders to Cures Symposium focused on efforts to scale mechanisms-focused research in genetic diseases. This event is hybrid and open to all. Please visit broad.io/L2C to register and see the agenda.
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10 Jul 2023
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Our #LaddersToCures Inaugural Symposium @broadinstitute partnering with @BostonChildrens @MGBInnovation @MassGeneralNews @BrighamWomens @IAmBiotech and many more leaders and innovators in biomedicine.
Join us on July 18! Visit broad.io/L2C
10 Jul 2023
Our team is excited to invite you to the inaugural Ladders to Cures Symposium focused on efforts to scale mechanisms-focused research in genetic diseases. This hybrid event is July 18, 2023. Please visit broad.io/L2C to register and see the agenda. @broadinstitute
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Anna Greka retweeted
12 Jun 2023
Congratulations to @HarvardMITmdphd student @JCoraorFried and mentor @AnnaGreka for Juli’s successful thesis defense entitled, “FALCON systematically interrogates FFA biology and identifies new mediators of lipotoxicity.” We are beyond proud! @grekalab @BBS_Harvard
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26 May 2023
Proud and honored to hood two @GrekaLab superstars Dr. Choah Kim @ChoahK and Dr. Juli Coraor Fried @JCoraorFried in today’s doctoral hooding ceremony @BBS_Harvard @harvardmed @broadinstitute @HarvardMITmdphd
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Congratulations to @GrekaLab artists @peach_arines, @SilvanaBazua, Brianna, and @JCoraorFried on the beautiful cover art for this issue of @Cell_Metabolism cell.com/issue/S1550-4131(22…
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