EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..? shorturl.at/vuCIh Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!

Absolutely. Every major idea I’ve had, and nearly every solution to a roadblock when executing those ideas in the lab, has arisen from long periods of solitude. It’s no mystery - the process of discovery involves winnowing through an infinite thicket of possibilities to find the answer, and any interruption to this reverie crashes the whole edifice of thought to the ground.

Isn't that true for any observation in science? 🧐

Rising undergrad junior or senior? Last chance to apply! Applications close TOMORROW, Dec. 22, 11:59pm EST. Our 9-week summer research experience includes hands-on lab work, a generous stipend, & mentorship from some of the nation’s top scientists. Learn more & apply at bit.ly/CechFellows.

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The Gonzalez Lab at Columbia University is seeking a scientific leader! Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes. Apply: apply.interfolio.com/176949

Two back-to-back stories on mitosis led by my incredible postdoc @KrunoVuk at @institutrb, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @NatureComms doi.org/10.1038/s41467-025-6… doi.org/10.1038/s41467-025-6…

We are accepting applications for 2 tenure track faculty positions at UTSW in the Department of Cell Biology! Apply before October 31st!

If you’re around in NYC, and studying microtubules or mitosis, this one is not to be missed!

Excited to share our new paper! mtDNA mutations contribute to mitochondrial disease and aging only if they rise in abundance. We show that deleterious mutations reach high abundance by hitchhiking on genomes that have a replicative advantage rdcu.be/eugVO

Here’s to all my colleagues rocking bowties! Happy #BowtieDay! Shoutout to @SandyBoynton for the image. #Style #WorkLife

If you're finishing PhD soon and thinking of postdocs, see below! Especially if you're keen on combining biochemistry, imaging and cell biology, we are onto some exciting findings on molecules and mechanisms underlying a cytoplasmic division cycle autonomously of CDKs!!

#Postdoc opportunity at Columbia U. in New York! We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU! hhmi.wd1.myworkdayjobs.com/E…

🚨Thrilled to announce I will be presenting our work at the Cold Spring Harbor Genome Engineering: CRISPR Frontiers Meeting (@CSHL) Aug 12–16! 🧬✨ We're combining cutting-edge in vivo CRISPR strategies with cancer research to uncover how mutant p53 drives metastasis—mutation by mutation. From high-throughput in vivo CRISPR knockout screens to precision base & prime editing, this project dissects tumor evolution at an unprecedented resolution. Our findings underscore the emerging potential of allele-specific treatments in precision oncology. Let’s talk CRISPR, cancer, and innovation! #cshlcrispr25 #CRISPR #p53 #cancerresearch #metastasis #CancerGenomics @cshlmeetings @ColumbiaMed

I think a good rule of thumb is to spend at least as much time thinking about your data as you did obtaining it. It's common for people to spend a lot less time thinking than doing which gives rise to all kinds of problems.

I'm pleased to share this work now published in @PLOSBiology! Since our preprint, we've uncovered exciting new links connecting CCDC66 to actin, vesicular trafficking, and Wnt signaling, and revealed how these contribute to CCDC66's ciliary functions. See link below!

In case this is not obvious: Expecting to understand and predict human biology based solely on modelling nucleic acids is naive. It’s unrealistic.

Join the #VosshallLab as a postdoctoral scientist! Fully funded position in New York City @RockefellerUniv hhmi.wd1.myworkdayjobs.com/e…

I’m happy to share that my latest PhD work is published in @embojournal! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. embopress.org/doi/full/10.10…

🚨New paper alert!🚨 Our latest work uncovers how cells detect and destroy defective ribosomes before they cause harm. A key quality control pathway with implications for development and disease. #ribosome #qualitycontrol Check it out in Molecular Cell: authors.elsevier.com/a/1l2MA…

This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. @Eric_E_Zhang @susanksgolden @ @SRBR_Outreach rdcu.be/efxV8