Protein design & synthetic biology • Asst. prof. @ETH_BSSE
Joined July 2020
- Tweets 97
- Following 421
- Followers 1,561
- Likes 76
13 Photos and videos
Pinned Tweet
7 Dec 2023
Excited to share that I'll be starting a group @ETH_BSSE researching at the intersection of protein design, biology and AI. Come join us!
x.com/ETH_en/status/17327826…
7 Dec 2023
On the proposal of ETH Zurich President @Joel_Mesot
, the ETH Board appointed 12 professors and awarded the title "Professor of Practice" once. 👨🏫👩🏫 brnw.ch/21wF6YH @MortezaAramesh @ellliottt
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Basile Wicky retweeted
Feb 23
#JobAlert 🚀 Exciting opportunity for young scientists - please share: tinyurl.com/2rajyepc
@ETH_en #BIIE @BaselStadt
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Feb 23
We're hiring! If you're interested in applying protein design to improving AAV we'd love to hear from you! Fully-funded 2 year collab postdoc between my group at ETH D-BSSE (in Basel) and Denis Phichith at Roche.
Job description and application portal: lnkd.in/e3P7HXt4
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Feb 18
New lab preprint! We used design to sample protein space, and developed a HT NMR pipeline to analyze 384 designs; a first glance into seq-struct-dynamics at scale! An exciting collaboration with @HillerLab, and @DlanAbr's first paper! biorxiv.org/content/10.64898…
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Basile Wicky retweeted
19 Mar 2024
Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠
nature.com/articles/s41589-0…
Special thanks to @eaandrzejewska , Danny Sahtoe and David Baker
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Basile Wicky retweeted
23 Feb 2024
Short summary thread of our recent review on de novo protein design:
(Poster-sized figure (36 x 48 inches) for printing: drive.google.com/file/d/1sG3…)
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Basile Wicky retweeted
12 Feb 2024
I keep on preaching to my lab about the usefulness @ChatGPTapp for coding, but real-life demos might be more effective. A thread on a neural network we quickly developed to classify antibiotics sensitivity 🧵 (1/10)
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Basile Wicky retweeted
25 Jan 2024
The commentary I wrote is now live at Nature Biotech: nature.com/articles/s41587-0… (free version rdcu.be/dwSSy).
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25 Jan 2024
Continuous directed evolution is so cool 🥹
25 Jan 2024
Excited to share - EcORep! Now you can simply electroporate a PCR product into E. coli and let the linear DNA replicate orthogonally in the cell. EcORep can be used to evolve proteins rapidly and continuously! science.org/doi/10.1126/scie…
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Basile Wicky retweeted
23 Jan 2024
LigandMPNN preprint: biorxiv.org/content/10.1101/…
LigandMPNN inference code model weights (including ProteinMPNN, SolubleMPNN etc): github.com/dauparas/LigandMP…
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10 Jan 2024
Beautiful work by the talented @KieraSumida and Reyes! Their findings on the quantitative tradeoff between seq conservation, designability and function (fig. 3f/g) is particularly insightful, and will be useful for many future protein engineering efforts!
9 Jan 2024
Our paper using ProteinMPNN redesign for improved properties is up on JACS! Huge thanks to Reyes, @ikalvet, Sam, and many others for their work. Shout out to @JustasDauparas for developing such a groundbreaking (and versatile!) tool. @UWproteindesign
pubs.acs.org/doi/full/10.102…
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Basile Wicky retweeted
22 Dec 2023
#openposition Exciting opportunity for a #postdoc: be part of the partnership @ETH_en and @Roche and become a Next-Gen Bioengineer > u.ethz.ch/m4Lwj Thanks for sharing!
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Basile Wicky retweeted
22 Dec 2023
Expanding protein pore palette beyond biology. Computational design of protein pores with various shapes and sizes. (Potential applications: Nanopore sensing, DNA/Protein sequencing, Custom pores for selective membranes and ligand-gated channels for cellular delivery.....)
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Basile Wicky retweeted
22 Dec 2023
We are hiring! Come join us for a PhD in Computational Language Evolution @ETH in Basel @ETH_BSSE and the National Research Program on Evolving Language @NCCR_Language. We are looking forward to receiving your application jobs.ethz.ch/job/view/JOPG_e…
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Basile Wicky retweeted
6 Dec 2023
We're looking for a PhD student interesting in protein design and tech development. Exciting project interfacing protein @structbiolbxl and solid-state nanopores @imec_int. Computational design of hybrid nanopore sensors. Apply by December 15th! imec-int.com/en/work-at-imec…
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Basile Wicky retweeted
5 Dec 2023
Dorado v0.5 NCM release 🎉
- new simplex models
- faster
- higher accuracy
- easier to use (auto model selection)
- hemi-methylation (duplex mods)
- primer & adapter trimming
- custom barcodes
#nanoporeconf
github.com/nanoporetech/dora…
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Basile Wicky retweeted
Is binarization of scATAC-seq data really necessary? The conclusion from our analysis is that a quantitative treatment is in fact beneficial. Now out in Nature Methods! @gagneurlab @fabian_theis nature.com/articles/s41592-0…
Many additions since the preprint 👇(1/n)
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Basile Wicky retweeted
4 Dec 2023
For anyone interested in generating publication-quality secondary structure diagrams from PDB files, SSDraw is available and now published by @ProteinSociety onlinelibrary.wiley.com/doi/…
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Basile Wicky retweeted
25 Nov 2023
Check out our latest work on a new algorithm for protein clustering and the discovery of new CRISPR systems! More on this soon. So grateful to have this work published by @ScienceMagazine !
23 Nov 2023
Using a new algorithm called FLSHclust, researchers have revealed rare and previously unknown #CRISPR-Cas systems.
The approach and results provide novel opportunities for understanding the vast functional diversity of microbial proteins. scim.ag/4W6
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