Unraveling the secrets of bacterial injection needles .. (among other things)
Joined August 2010
- Tweets 132
- Following 13
- Followers 1,884
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13 Photos and videos
May 3
Congratulations to Alea on winning a Gold Medal🥇and a trip to the Taiwan International Science Fair!
The 4th top prize in a row under our mentorship. Huge thanks to @biozentrum, @NCCR_AntiResist, @UniBasel_en for their continuous support.
Read more:
inspiration.sjf.ch/identific…
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Apr 26
Check this video describing Alea's high-school graduation project done in our lab:
youtu.be/b9hG_RedCQs?si=1KYN…
Thanks to @biozentrum and @NCCR_AntiResist for support.
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9 Dec 2025
Thank you, Katrin (@biozentrum) for a great summary of our paper!
You can also check out this "Behind the Paper" written by @ATejadaArranz:
communities.springernature.c…
8 Dec 2025
New research by @Basler_Lab reveals a surprising microbial trade-off: The bacterium Pseudomonas aeruginosa activates a general defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. 👇biozentrum.unibas.ch/news/de…
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28 Nov 2025
Big congrats to @ATejadaArranz and co-authors on this paper showing novel insights into the resistance to #T6SS effectors and an unexpected link to antibiotic resistance!
Thanks @NCCR_AntiResist for funding and supporting the collaboration with @JenalLab!
nature.com/articles/s41467-0…
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17 Nov 2025
Update to BacFighT6, with presets for easy exploration of complex behaviors:
sites.google.com/view/bacfig…
Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate!
Took a while to eliminate the reds!
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14 Nov 2025
Happy to share our latest T6SS review:
nature.com/articles/s41579-0…
Thank you, @jan_wohlfarth, @DannyJamesWard, and @Joana_MPereira as well as reviewers and editors @NatureRevMicro!
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15 Jun 2025
Major update to BacFighT6: sites.google.com/view/bacfig…
Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!
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15 Jun 2025
Check out the NotebookLM powered interactive Q&A: sites.google.com/view/bacfig…
This is based on the scientific literature and the simulation code. Literature is cited in the help and the documentation. Extremely helpful!
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15 Jun 2025
The prey (blue) multiply, don't move and produce capsule (purple). The predators (red) move towards prey and attack non-kin. They divide only if they lyse prey. The defenders (orange) move randomly and defend themselves by retaliation (divide if they lyse a cell). Who wins?
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26 May 2025
To make our research more approachable, I used #Gemini to develop (mostly by #vibecoding) a simulation of #T6SS mediated bacterial interactions. I hope that you'll have as much fun as I have with this and that you'll learn something new!
sites.google.com/view/bacfig…
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26 Apr 2025
Happy to help William with his high school graduation project:
inspiration.sjf.ch/the-role-…
youtu.be/u0d72T9rRQg?si=koTM…
Congratulations!
Thanks to @biozentrum and @NCCR_AntiResist for support.
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5 Mar 2025
Poke bacteria with a sharp needle and they poke back in just a few seconds!
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum @SNIunibas!
science.org/doi/10.1126/scia…
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5 Mar 2025
Thank you, Katrin, for a great news article:
Damaged but not defeated: Bacteria use nano-spearguns to retaliate against attacks
biozentrum.unibas.ch/news/de…
And the @SNIunibas for producing this video summary:
youtu.be/0uOVdcOy3vQ?si=p7Eu…
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Basler Lab retweeted
3 Mar 2025
Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until May 18, 2025. bit.ly/4caiqqX @biozentrum @UniBasel_en
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Basler Lab retweeted
18 Jul 2024
Assistant/Associate Professor in Structural Biology, Biological Imaging or Biophysics
ow.ly/lxVP50SF2iy
#Biozentrum #Basel #research #science #joboffer #Assistant #Associate #Professor
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14 Jul 2024
For over 10 years, we've known that neighboring P. aeruginosa cells engage in rounds of H1-T6SS firing. It was unclear how this starts since H1-T6SS only fires in response to an attack. Now we know:
journals.asm.org/doi/10.1128…
Congrats Max, Sharath, Alejandro, and others!
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30 Apr 2024
Happy to support Gabriela's successful high school graduation project!
More information here:
inspiration.sjf.ch/iron-regu…
Thanks to @biozentrum and @NCCR_AntiResist
for support as well as to @SJf_CH for organizing the competition!
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19 Apr 2024
Thank you, Katrin (@biozentrum), for a great summary of our work!
biozentrum.unibas.ch/news/de…
19 Apr 2024
Exciting discovery by @PlumifyM & @Basler_Lab: The intracellular pathogen #Burkholderia uses the #T6SS nano-speargun to spread in the body without being recognized by the immune system.
@biozentrum @Unibasel_en @cellhostmicrobe @ERC_Research
ow.ly/BBNe50RjBf7
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