Motivated to understand the mechanisms underlying cellular dynamics like filopodia function, cell surface repair, membrane organization using biophotonics
Our new review on @filopodia is out in Trends in Cell biology. It is an easy to read review combining theoretical models with experimental findings. sciencedirect.com/science/ar… Please contact me if you need the pdf file. bendix@nbi.dk
Our new review on 'Biological Applications on Thermoplasmonics' with a bunch of exciting applications. E.g. a brand new clinical trial has proven extremely promising results for prostate treatment using photo thermal therapy. pubs.acs.org/doi/epdf/10.102…
Dynamics of influenza spike proteins revealed by a physical method called thermoplasmonics. See our new Nano Letters paper on how virus proteins can be be investigated in hybrid vesicles made from GUVs and plasma membranes from transfected cells. pubs.acs.org/doi/10.1021/acs…
Who says science has to be all boring graphs and tables? 📊
I’m exhited to share that my illustrations have been featured on the front cover of two scientific journals! For me it doesn’t get much bigger than this 🤩
Huge thanks to my co-authors on these papers ⬇️
Is biology using molecular crowding for bending membranes or no? We have tried to give a balanced and critical review on this matter in a new review published in Biochemical Society Transactions - Ruhoff et al. 2022:
portlandpress.com/biochemsoc…
Thermoplasmonic rupture of cells cause immediate recruitment of the membrane protein annexin A5. This novel approach brings new insights into annexin A5 contribution to repairing cell membranes! Read the @nanoscale_rsc article by @G_MorPes @BendixLab 👉 pubs.rsc.org/en/content/arti…
ALT Navy background with illustration of nanoscopic hole in cell plasma membrane
New paper in Nature Communications on how filopodia from many different cell types exhibit fascinating twisting rotations: nature.com/articles/s41467-0…
#EESCellSurface Enjoying a fantastic conference/workshop with many interesting topics focusing on the life at the cell periphery- what a life...Hope this event will be repeated in real life in 2 years.
3- and 4-color scanning FCS to determine higher-order protein interactions and diffusion dynamics in living cells.
Also, extending the nice new RICS approaches by @prof_jelle to determine the stoichiometry of the ternary influenza A polymerase complex.
Feedback is welcome!
Finally out our paper in @nature: "Active particles induce large shape
deformations in giant lipid vesicles".Thanks to all my coauthors @JanVermant,Gerhard,@FedosovDA,@tabajure,Masoud, Clara, Ale,Lennard! Fruitful collaboration between @ETH_en&@fz_juelich
nature.com/articles/s41586-0…
New type of filopodia dynamics revealed in our biorXiv preprint biorxiv.org/content/10.1101/…
Filopodia exhibit true spinning or twisting around their own axis and display beautiful helical coils as predicted by active matter simulations.
ALT Tracer particles, linked to the actin core at the side of the fiopodium using optical tweezers, report about the twising of the actin core.
One of the program organizer of the 2021 BPS meeting will be Patricia Bassereau @BiophysicalSoc@BiophysJ Despite the invisible enemy that locks us down, with such an organizer I am looking forward to an exciting program biophysics.cld.bz/Biophysica…
I could see that nanotube formation depends on the cell line. U2OS cells seem to form particularly large GPMVs, maybe that is connected. PS: The referenced pre-print is quite preliminary and I will post an update on biorxiv next month.
Finally, our work curvature sensing of Annexin A4 in GPMVs became published in Soft Matter. A great collaboration between theorists and experimentalists.
pubs.rsc.org/en/content/arti…