🔬Research Group focused on Stem cells and Cancer at @HMar_research @CarrerasIJC 👩🔬👨🔬 Dr. Anna Bigas and Dr. Lluís Espinosa working together since 1998
Joined July 2019
- Tweets 220
- Following 279
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47 Photos and videos
The 7th NF-kB International Congress is here!
📅 October 7–9, 2026
📍 Barcelona Biomedical Research Park (PRBB)
Join leading experts to explore the latest advances in signaling, inflammation, and disease.
🔗 Register now and don’t miss it!
#NFKB #BiomedicalResearch #Barcelona
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Bigas/Espinosa Lab retweeted
🔬Researchers from @HMar_research & @hmarpath have identified a key mechanism behind colon cancer metastasis.
🧬A lack of the IKKα protein enables tumour cells to cluster together & survive during dissemination.
📊@NatureComms.
🗞️More: researchmar.net/news/806/
@hospitaldelmar
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Bigas/Espinosa Lab retweeted
📣Happy to start the year by sharing our team’s latest work on the development of dormant hematopoietic stem cells (HSCs), now available on bioRxiv: biorxiv.org/content/10.64898…
We show that a population of dormant HSCs with high regenerative capacity is established in the embryo.
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11 Dec 2025
Happy to share our minimal fetal-like gene signatures (ColoStem & EpiColoStem) that identify high-risk colorectal tumors in >1,100 patients and are measurable by qPCR in tissue and plasma, enabling patient stratification for future targeted therapies.
nature.com/articles/s41416-0…
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Bigas/Espinosa Lab retweeted
20 Nov 2025
Desxifren els esdeveniments genètics que desencadenarien una leucèmia en pacients d’un trastorn rar: la deficiència en GATA2🧬
L’estudi s’ha fet gràcies a models avançats del trastorn fets pels investigadors, una eina clau en la recerca d'ara endavant
👉 idibell.cat/2025/11/desxifre…
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Bigas/Espinosa Lab retweeted
15 Nov 2025
La Dra. Anna Bigas, investigadora @HMar_research i @CarrerasIJC, s'incorpora com a #editoraassociada a @Dev_journal📰
Està centrada en el camp de la biologia del desenvolupament i malalties associades a processos embrionaris
@Co_Biologists @BigSpinLab
hospitaldelmar.cat/ca/notici…
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Bigas/Espinosa Lab retweeted
11 Nov 2025
We are delighted to welcome Anna Bigas (@BigSpinLab) from Hospital del Mar Research Institute and Josep Carreras Leukemia Research Institute as a new Associate Editor at Development, handling papers on #haematopoiesis, #signalling and #cancer.
journals.biologists.com/dev/…
ALT Anna Bigas Associate Editor, Development Hospital de Mar Research Institute (HMRIB) and Josep Carreras Lukaemia Research Institute (IJC), Spain "I look forward to handling appers on developmental haematopoiesis and haematopoietic stem cells. I can also handle Notch signalling papers in different systems, as well as papers on cancer and leukaemia mechanisms." Key topics: development and disease, haematopoiesis, signalling, stem cells.
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Bigas/Espinosa Lab retweeted
31 Oct 2025
Check out this new research from the @BigSpinLab!
The authors found that IκBα accumulates specifically in the chromatin fraction of mPSCs.
📚 More in @eLife: bit.ly/3Wt1Lsl
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Bigas/Espinosa Lab retweeted
13 Oct 2025
🩸Desarrollan modelos de embrión en laboratorio que producen células sanguíneas
🗨️Anna Bigas @BigSpinLab: "Es un trabajo muy preliminar que sugiere que, con las condiciones adecuadas, seremos capaces de obtener muchos tipos celulares"
sciencemediacentre.es/desarr…
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9 Oct 2025
It's always a pleasure to work together!🔬👩🔬
9 Oct 2025
New paper from our lab finally online 🔥. Congrats to the amazing first author 👏🏽 @Fra_Matteini💥, wonderful collaborators Anna Bigas @BigSpinLab and Antonio Del Sol @delSolLab
Stem Cell Aging Team @idibell_cat
👇🏽👇🏽👇🏽
Notch in HSC aging doi.org/10.1182/blood.202402…
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Bigas/Espinosa Lab retweeted
9 Oct 2025
New paper from our lab finally online 🔥. Congrats to the amazing first author 👏🏽 @Fra_Matteini💥, wonderful collaborators Anna Bigas @BigSpinLab and Antonio Del Sol @delSolLab
Stem Cell Aging Team @idibell_cat
👇🏽👇🏽👇🏽
Notch in HSC aging doi.org/10.1182/blood.202402…
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Bigas/Espinosa Lab retweeted
22 Sep 2025
📢New Workshop on NF-kB: Cell Plasticity and Cancer
📅 Tues 23 Sep
⏰ 9.30 h
📍 Charles Darwin Room
The workshop will feature presentations from a range of distinguished experts in oncology research
ℹ️ researchmar.net/agenda/977/w…
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Bigas/Espinosa Lab retweeted
18 Jul 2025
Thrilled to share with you the latest work from my PhD in @BigSpinLab @HMar_research @CarrerasIJC published in @BloodPortfolio
We’ve programmed blood stem cells from PSCs using CRISPRa screen and found a new “bloody” cocktail
#CRISPR #HSCs #StemCells
kwnsfk27.r.eu-west-1.awstrac…
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18 Jul 2025
🚨New paper out!🚨
🔬 CRISPRa screening during mesodermal differentiation identifies 7 key genes with HSC induction potential.
🧬 A 7-gene cocktail drives multilineage repopulation and self-renewal from mouse ESCs.
📄 Don’t miss it!
doi.org/10.1182/blood.202402…
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Bigas/Espinosa Lab retweeted
8 Jul 2025
🔬 Join us for the next @hmar_research-@UPFbiomed
Seminar!
🗓️15/07 📌Charles Darwin Room
Talks by @bigas_anna @BigSpinLab & @AMartinezArias @icreacommunity
👉researchmar.net/agenda_en/91…
ALT We invite you to the next Hospital del Mar Research Institute /MELIS UPF Seminar that will take place on Tuesday 15/07/2025 at 12:00h in the Charles Darwin Room. The seminar will consist of two talks, one by Anna Bigas, Stems cells and cancer research Group. Hospital del Mar Research Institute with the title "Using embryonic stem cells to understand blood development" and the other by Alfonso Martinez Arias, ICREA Senior researcher Universitat Pompeu Fabra under the title "Modelling mammalian gastrulation with Pluripotent stem cells."
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11 Jul 2025
🚀 New paper out! 🔬Discover how IκBα exerts distinct chromatin- and NF-κB-related regulatory functions, and how its chromatin-related activity restores intestinal stem cell function & differentiation 👉cell.com/cell-reports/fullte…
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Bigas/Espinosa Lab retweeted
💬 "Som més a prop del somni científic de crear sang artificial amb finalitats terapèutiques"🩸
🔬📺 La recerca del @BigSpinLab, a les notícies de @som3cat
➡️ 3cat.cat/324/som-mes-a-prop-…
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Bigas/Espinosa Lab retweeted
19 May 2025
A step closer to the confident production of #bloodstemcells for regenerative medicine
Study published in @BloodJournal, from @BigSpinLab, @HMar_research and @CarrerasIJC
@ASH_hematology @Menendez_Lab @clarabueno_74 @CienciaGob @recercauniscat
researchmar.net/news/723/a-s…
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11 Apr 2025
Happy to share that our work ‘An unbiased genomewide screen uncovers 7 genes that drive hematopoietic stem cell fate from mouse embryonic stem cells’ as first edition in @BloodJournal.
Thank you to all collaborators for making this work possible!
ashpublications.org/blood/ar…
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