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Jeffrey Brault, PhD @BraultMuscleLab

Associate Professor in the Center for Musculoskeletal Health at the Indiana U School of Medicine. Skeletal muscle energetics and the control of muscle mass.

Joined November 2021
  • Tweets 28
  • Following 301
  • Followers 410
6 Photos and videos
Thrilled to publish our skeletal muscle-centric study of mitochondrial transacylase deficiency. The NMJ adaptations are surprising. Awesome work by post-doc Catalina Matias and wonderful collaboration with Simon Conway and lab. @IUICMH @IUImpact society-scwd.org/deficient-c….

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition And Neuromuscular Connectivity In...

BACKGROUND Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While...

society-scwd.org
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Jeffrey Brault, PhD retweeted
The Hornberger Lab@HornbergerLab
Jan 21
📢Tenure Track Faculty Position: UW-Madison is expanding its research portfolio in aging and is interested in applicants who study the interplay between aging and skeletal muscle biology. 10 days left to apply - please RT and DM if you have questions. jobs.wisc.edu/jobs/immunolog…

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2nd Annual Global ADSS1 Scientific & Clinical Conference in Boston, MA was a great success - demonstrating massive progress in understanding this devastating myopathy of purine metabolism. I'm fortunate to be a small part of this dedicated group. #ADSS1
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Jeffrey Brault, PhD retweeted
Marcas Bamman, PhD@MarcasBamman
11 Feb 2025
Join us!
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Have you ever wondered whether ATP alone is a good measure of mitochondrial function? It is not! In this review, we address ATP and the energetic state in a mitochondrial metabolic disorder. @IUICMH @IUImpact oaepublish.com/articles/jtgg…

What can ATP content tell us about Barth syndrome muscle phenotypes?

Adenosine triphosphate (ATP) is the energy currency within all living cells and is involved in many vital biochemical reactions, including cell viability, metabolic status, cell death, intracellular...

oaepublish.com
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Happy to be a small part of this impressive study on the integrated stress response and purine metabolism in prostate cancer cells.
Advanced Prostate Cancer Consensus Conference
@APCCC_Lugano
27 Nov 2024
Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer science.org/doi/10.1126/scis… This study explores how the integrated stress response (ISR) helps prostate cancer cells survive, particularly those lacking the p53 tumor suppressor. Researchers found that inhibiting the ISR kinase GCN2 in p53-deficient #ProstateCancer cells disrupts amino acid availability, which is crucial for purine nucleotide synthesis. This disruption is deadly to p53-deficient cells because they cannot initiate the protective cell cycle arrest and senescence that p53 typically triggers. In contrast, p53-functional tumors can survive GCN2 inhibition. In mouse models, GCN2 inhibition slowed tumor growth in both types but was especially lethal to p53-deficient tumors, suggesting a potential therapeutic strategy for targeting p53-deficient prostate cancers. @BraultMuscleLab @kirkstaschke Ping @nataliagandur @yekeduz_emre @bavilima
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Happy to share our exciting, new mito-myopathy model — KO of Sucla2. Despite similar loss of enzyme activity and increase in protein succinylation across muscles, we show dramatic muscle-specific phenotypic changes between muscles. onlinelibrary.wiley.com/doi/…

Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle...

Background Pathogenic variants in subunits of succinyl-CoA synthetase (SCS) are associated with mitochondrial encephalomyopathy in humans. SCS catalyses the conversion of succinyl-CoA to succinate...

onlinelibrary.wiley.com
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I'm happy to be part of this exciting conference on a devastating but rare neuromuscular disease, ADSSL1 myopathy. Looking forward to learning from these experts. #ADSSL1 #RareDisease
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While uric acid is largely thought to be produced in the liver, where do the precursors come from? Muscle! Excited to share that this major piece of @SpencerGMiller dissertation work was selected for the cover of @JCI_insight @IUICMH
JCI insight
@JCI_insight
23 Jan 2024
#Cover: Uric acid formation is driven by crosstalk between skeletal muscle and other cell types: buff.ly/3SpUND9 An immunofluorescence #image of C2C12 myotubes displaying myosin heavy chain (orange) and nuclei (blue); Credit: @SpencerGMiller @BraultMuscleLab @IUMedSchool
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ADP concentrations generally cannot be measured in vivo, but they can be accurately estimated in muscle! Happy to be a small part of this tour de force to integrate major physiological factors into the calculations of creatine kinase equilibrium. mdpi.com/1422-0067/24/17/132…

Creatine Kinase Equilibration and ΔGATP over an Extended Range of Physiological Conditions:...

In this report, we establish a straightforward method for estimating the equilibrium constant for the creatine kinase reaction (CK Keq″) over wide but physiologically and experimentally relevant...

mdpi.com
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Jeffrey Brault, PhD retweeted
Kelsey Fisher-Wellman, PhD@KFW_Lab
5 Jun 2023
Excited to announce our group's latest preprint led by @IlyaNBoykov @Mcmontgomery11 biorxiv.org/content/10.1101/… In it we compared OXPHOS expression/function, across various murine tumor types, matched normal tissues and other organs -- all normalized to mito content. 🧵below

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across tumor types

Targeting mitochondrial oxidative phosphorylation (OXPHOS) to combat cancer is increasingly being investigated using a variety of small molecule inhibitors. Clinical success for these inhibitors has...

biorxiv.org
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Jeffrey Brault, PhD retweeted
Shenhav Shemer Lab@Shenhav_Lab
18 Apr 2023
It is with great sadness that we mourn the passing of Prof. Alfred Goldberg, my postdoc mentor and colleague. Fred’s contributions to science were profound and far-reaching, and his passing leaves a void. He was a passionate advocate for science and education. We will miss him.
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Jeffrey Brault, PhD retweeted
Everett Minchew@everettminchew
22 Mar 2023
No oxygen? No problem 💪 Thrilled to reveal evidence of a mammalian skeletal muscle that functions properly without O₂. A massive effort by the team! @EspenLab @APS_Function @MYOTWlTTER #myotwitter academic.oup.com/function/ad…

Function

journals.physiology.org
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Another great day at the Advances in Skeletal Muscle Biology Conference at University of Florida #MyoTwitter
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Jeffrey Brault, PhD retweeted
Journal of Applied Physiology@japplphysiol
16 Sep 2022
#ArticlesInPress “Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1” By: Paul S. Hafen, et al. ow.ly/19VJ50KLsc6 #JAPPL #Fatigue #SexDifferences
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Jeffrey Brault, PhD retweeted
Kelsey Fisher-Wellman, PhD@KFW_Lab
6 Sep 2022
📢#Mitochondria and #Cancer drug resistance📢 How much energy does it cost to run drug efflux pumps? This and more are what we set out to answer in our latest work, just published in BBA – Bioenergetics. sciencedirect.com/science/ar… 🧵below 1/

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Congratulations Dr. Miller @SpencerGMiller on your successful PhD defense! One of the great pleasures of being an academic professor is the success of your students. I am proud of Spencer and am confident he will continue to achieve great things.
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We are excited to share our new chromatography method for ATP and associated molecules. This was driven by graduate student Andrew Law. sciencedirect.com/science/ar…
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Jeffrey Brault, PhD retweeted
Jake Hines@jhhines2
8 Jul 2022
We've developed smartphone fluorescence microscopes, aka Glowscopes. A few simple and inexpensive components convert your smartphone into a basic fluorescence microscope. 1/n
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