🎉 Huge news!! OurHealth is returning research polygenic risk scores for coronary artery disease. This is offered through our new ancillary study, OurHealth-PRS. You are eligible if you’ve joined the OurHealth main study, returned your saliva sample, and it has been sequenced.

💜 All sequenced participants of @ourhealthstudy are eligible to have a free coronary artery disease PRS (same as in the @MassGenBrigham /@broadinstitute test) as a part of a research ancillary study! Details to sign up 👇 @kparuchuri @AniruddhPatelMD @amitvkhera @skathire @_aarushib @shriieganesh @DrMarthaGulati @iamritu @purviparwani

Won-Seok Lee @broadinstitute, receives 2026 Nancy S. Wexler Young Investigator Prize, awarded to an early career researcher whose work reflects the highest caliber of excellence, diligence & creative thinking. Learn more tinyurl.com/nswprize #curehd #huntingtonsdisease

When we lower PrP in prion-infected mice, how much good we can do depends critically on how much time they've got left. A key reason: PrP has a 5 day half-life in vivo. This is why we need to accelerate diagnosis, particularly in rapid subtypes. Paper: journals.plos.org/plospathog…

We took ~750,000 whole genomes and found the putative mechanism by which mitochondrial DNA mutations accumulate with age in blood. Spoiler: we think these mutations arise by replication error and tag age-related clonal hematopoiesis. Read @Nature broad.io/ob2jft

PBS News Hour recently featured Broad researchers Jim Collins, @MelisAnahtar, and team for their work using deep neural networks to generate and screen billions of theoretical molecules in the search for next-generation antibiotics to combat drug-resistant infections.

New research in @NatureMedicine co-authored by @DanaFarber’s Dr. Suzanne George and @BradEBernstein reveals the clinical activity of FGFR inhibition in SDH-deficient GIST. This trial illustrates successful demonstration of targeted cancer therapy predicated on an epigenetic mechanism of oncogene activation. Read more: bit.ly/497QeW8 @broadinstitute

Delighted to share the final version of our story on mtDNA mutations and aging, published today. We show mtDNA mutation burden is a sensitive marker of somatic mosaicism (due to CHIP) in blood. Curious if this pattern will extens to solid organs, too. rdcu.be/fk4Ou

1/ Excited to share our preprint on the Cancer Immunotherapy Machine Learning Competition: broad.io/MLC-2023 - the first of the ongoing @SchmidtCenter Cell Perturbation Prediction Challenge (CPPC) series. Here are some key points! 🧵👇

AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing go.nature.com/49yUr5t

Dravet syndrome is a rare, often fatal form of childhood epilepsy. New research from #HHMIInvestigator David Liu & collaborators found that a single dose of base editing can correct its underlying mutation in mice, reducing seizures & extending survival: bit.ly/4nLvIAM.

Analyzing protein-coding variants across 1.2M individuals, our study by @skoyamamd identifies new targets for lipid and CAD therapeutics & informs genetic testing for Mendelian dyslipidemias nature.com/articles/s41588-0… @NatureGenet

🎉 A new preprint spearheaded by @JiaqiZhangVic reports the results of the first @Schmidt_Center machine learning challenge, the Cancer Immunotherapy ML Competition: broad.io/MLC-2023

Today in @NatureBiotech we report a new suit of PE8 prime editor proteins. PE8 variants were developed from laboratory-evolved PE6 proteins using AI-guided protein redesign. This approach combines recent advances in computational protein design and directed evolution to increase prime editing efficiency, especially in transient therapeutically relevant delivery settings such as mRNA pegRNA electroporation into primary cells, eVLP delivery of prime editing RNPs, and LNP-mediated mRNA pegRNA delivery in mice. drive.google.com/file/d/13VT… 1/11

Excited to share the first co-first author paper from my postdoc in @davidrliu’s group @broadinstitute, out now in @NatureBiotech! We used AI-guided computational redesign to develop new PE8 prime editors. See David’s thread below!

Directed evolution of small RNA-stabilizing motifs that improve prime-editing efficiency go.nature.com/4wLWKMu

Today in @NatBiotech, we report the directed evolution of structured RNA motifs that enhance the efficiency of prime editing. Iterated high-throughput pooled screens and mutagenesis of these small RNA elements improved transient pegRNA lifetime. drive.google.com/file/d/1Nyt… 1/11

🎉 The next phase of the @Schmidt_Center Obesity ML Competition is LIVE! hub.crunchdao.com/competitio… This challenge is open to researchers from all backgrounds — no machine learning expertise required.

🎉Happy to share our (@LinkeLi_MGH @tigerstatdoc @M_Mesbah_Uddin @abhinrl @pnatarajanmd me) collaborative article with Reuben & Santhosh's team at @IUMedSchool, just out in @BloodPortfolio! Clonal hematopoiesis of indeterminate potential (CHIP)🧬is linked to multiple organ systems — heart, liver, brain — what about the colon? And if there is a causal link, can we do something about it? Using Dnmt3a-mutant mouse 🐭models of colitis and human🧓data from UK Biobank & Mass General Brigham, we show that CHIP increases inflammatory bowel disease (IBD) risk; further, APE1/Ref-1 inhibitor APX3330 can ameliorate CHIP-driven IBD, potentially breaking the CHIP-disease link. 🔗sciencedirect.com/science/ar…

Leveraging adenine #BaseEditing, researchers demonstrate high editing efficiency of mutant SCN1A in a newborn mouse model of #DravetSyndrome and show it can lower seizure frequency while boosting survival. @davidrliu @broadinstitute scim.ag/4tBdXVM