In @DrSpratticus editorial accompanying the PRIMARY2, there is a very effective metaphor that prompts us to pause before claiming that these data can already be considered a paradigm shift. A longer follow-up is needed for patients managed through the PSMA PET–based path. #radonc

A bit rough around the edges, but it effectively conveys the importance of the PRIMARY2 study in press on #radonc @TheLancetOncol @NotebookLM

Very deep review in press in @IJROBP about mechanism of resistance in #Glioblastoma (@AmyWisdom8 et. al DOI :doi.org/10.1016/j.ijrobp.202…) .This table provides an at-a-glance overview of the main resistance mechanisms discussed in the paper. #radonc

A symptomatic vertebral hemangioma treated with decompressive laminectomy stabilization post-op RT (45 Gy/25 fx). Excellent MRI response and recovery from paraparesis—another reminder of the value of RT in select benign conditions. #radonc ⚡

The EORTC GUCG-1414 study (@ZilliThomas et al., Eur Urol Oncol 2025) represents an important contribution—though with structural limitations—to the understanding of the clinical impact of different types of androgen deprivation therapy combined with radiotherapy in very high-risk or locally advanced prostate cancer. The following table provides a concise and pragmatic synthesis that may be useful in daily clinical practice.

Every ray that illuminates can also burn. Every instrument of healing can become a weapon. What saves, if used without measure, destroys. And yet, for more than a century, light has remained our ally. We have learned to modulate it, to measure it, to give it form. Sometimes it enters the body like an invisible blade; at other times, it moves around the tumor like a breath of energy. It is the same light that once burned in Grubbe’s hands — the same that made Edison’s bulb shine — and that now flows silently through the bunkers of radiotherapy, within the precise beams of the accelerators. There is no contradiction here, but a paradox: radiation kills, and precisely for that reason it can heal. As if life, in order to continue, had to learn to live with its own opposite. It is on this fragile, luminous frontier that medicine and physics meet. And in that meeting — between measure and abyss — hope still shines.

A few years ago, @rweichselbaum posed—ironically, but not entirely so—the question: what is the difference between radiotherapy and radiosurgery? In some ways, this review attempts to answer that very question. This table provides a synopsis of its contents. #radonc thegreenjournal.com/article/… #radonc

Grafico tratto da un articolo del The Economist. Gli Americani, per avere un accesso più rapido alle terapie con nuovi farmaci, le pagano da 2 a 5 volte in più rispetto alla media dei paesi OCSE. Questo è il risultato di un Sistema Sanitario affaristico, in cui non vige il principio di universalità. Speriamo in Italia questo non avvenga. I tempi grami in cui versa il #SSN non mi inducono all' ottimismo. @Cartabellotta