When residents ask you why "umbrella cells"?

When assessing and epididymal cyst!!! The guy was loaded!!

Need of repost: colon lipomas May have a wide morphology!! @Joaomgama How do you describe this one??

When amniotic band goes around a finger!!!

CRC therapy is no longer linear. It’s a network. 🧬 This figure beautifully captures the shift: From single-target inhibition → to multi-node pathway control TME modulation 🔬 MAPK backbone (RAS → RAF → MEK → ERK) Everything converges here - and resistance emerges here. 🎯 What’s new 🟠 KRAS targeting has evolved • G12C OFF inhibitors (sotorasib, adagrasib) • RAS(ON) inhibitors → broader allele coverage • PROTAC degraders on the horizon 👉 Monotherapy fails → EGFR co-blockade is essential 🔵 BRAF strategy is combination-driven • BRAF EGFR ± MEK now standard • Next-gen “paradox breakers” incoming 🟢 Upstream & parallel pathways • SHP2 / SOS1 inhibition to suppress signaling flux • MET, HER2, EGFR co-targeting 🧪 Beyond MAPK • ADCs (HER2, CEACAM5, CLDN18.2) • Bispecifics & T-cell engagers • ATR / WEE1 (DDR targeting) • Immunotherapy TME modulation 💡 Takeaway CRC is no longer about “one mutation, one drug.” It’s about: ➡️ Pathway interception at multiple levels ➡️ Adaptive resistance control ➡️ Biomarker-driven combinations 📖 Full paper in comment ⬇️ #OncoTwitter #MedTwitter #CRC #PrecisionOncology @OncoAlert @myESMO @ASCO @JCO_ASCO @esmo_open

molar pregnancy!!! is does not get better than this!!

Peutz Jeghers polyp! Love how IHC pops out the "tree morphology"

In the age of targeted therapy “the old” HER2 still has importance - in this case on a extra hepatic bile duct cancer

New online! Cholangiocarcinoma 2026: status quo, unmet needs and priorities bit.ly/4q14llS

Must repost! #PediPath

A new week and one more Classic lesion!! Serous cystadenoma Round 2!

One more round at @Pathoutlines pathologyoutlines.com/topic/… A very nice entry with the valuable contributtion of two brilliant pathologists!

Pathology classic!! Serous cystadenoma! Enjoy!

Tuning IHC is sometimes a difficult task, but when it works it's fantastic. GATA6 enters the battle!

when pathologist kills a bx of tumor with wasted #IHCpath stains & now clinical team can't send for NGS #pathmemes

Going for another round. From Escapães -> World. With great power comes great responsibility! What a great honour!