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Calen P. Ryan 🌊 @CalenRyan

PhD Research Scientist. Reproduction, Aging, Evolution, & (Epi)genetics🧬Stats and R nerd. Martial Artist. Motorcyclist🏍Outdoorsy⛺️ Aquatec🎧. He/him/eh 🇨🇦

Joined January 2015
  • Tweets 3,143
  • Following 1,331
  • Followers 634
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Calen P. Ryan 🌊@CalenRyan
14 Sep 2018
Trying to find evolution schemes depicting women. If you have one or wish to contribute, post here! #sciart #evolution (image: Eduardo Saiz)
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New work looking at how epigenetic clocks and cell composition derived from Illumina EPICv1 and v2 compare, led by our outstanding colleagues @UBC @koborlab Always thrilled to publish with such a great team!
Kobor Lab@koborlab
5 Jul 2024
Ever wondered about compatibility of @illumina #infinium V1 versus V2 #arrays for #epigenetics population studies including #epigenetic age & #risk scores? Check out our newest, courtesy of our wonderful #bioinformatics team and an awesome group of amazing @collaborators - enjoy!
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Calen P. Ryan 🌊 retweeted
Anna Medaris@AnnaMedaris
11 Jun 2024
My latest story for @AARP is live! As a bonus, I got to hang out with my editor IRL at this past weekend's @AHCJ conference in NYC. TY @mkaeberlein @CalenRyan @StevenAustad for your research & insight. aarp.org/health/healthy-livi… #aging #longevity #healthwriting #freelance
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Calen P. Ryan 🌊 retweeted
Lifespan News@LifespanNews
7 May 2024
🧬What is the link between telomeres and aging, and why does caloric restriction appear to influence them? A new study sheds some light. lifespan.io/news/exploring-h… @whastings2012 @Wolf_SarahE @CalenRyan @RacetteSusan @DrLeanneRedman @Danbelsky #TelomereAttrition #CALERIE #CR
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Stimulating questions and great discussion on our recent paper with @eabrown18 - read more about it in her article with @NatGeo!
Christine Dell'Amore@cdellamore
8 Apr 2024
Not news for us moms, but interesting nonetheless! By @eabrown18 for @NatGeo nationalgeographic.com/premi…
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We measured biological aging using 6 epigenetic clocks, a family of revolutionary tools for studying aging and predicting health and longevity. You can read more about them in my not too out-of-date review article. onlinelibrary.wiley.com/doi/…

“Epigenetic clocks”: Theory and applications in human biology

All humans age, but how we age—and how fast—differs considerably from person to person. This deviation between apparent age and chronological age is often referred to as “biological age” (BA) and...

onlinelibrary.wiley.com
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The effects we see are small, and we still don’t know the long-term implications. But this kind of research may one day help us identify who is at the greatest risk and devise ways to support them to minimize any long-term costs of reproduction.
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More broadly, these kinds of studies are highlighting how research in biological aging has often overlooked women and women’s health: we really think more carefully about pregnancy, menstruation, and menopause, when building, testing, and validating measures of biological aging.
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Our publication showing that pregnancy is associated with faster epigenetic aging is out now in @PNASNews! pnas.org/doi/10.1073/pnas.23… @koborlab @Danbelsky @ChrisKuzawa A thread about the paper below 👇

Pregnancy is linked to faster epigenetic aging in young women | PNAS

A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accel...

pnas.org
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To do this, we studied n=1735 young (20-22y old) men and women participating in the Cebu Longitudinal Health and Nutrition Survey (CLHNS), an ongoing, long-term study of growth, development, and health in the Philippines.
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We previously showed that parity was associated with biological aging among post-menopausal women. Here, we asked if it is possible to detect these ‘costs of reproduction’ among young adults, decades before they start to show signs of disease or mortality. x.com/talia_shirazi/status/1…

Talia Shirazi, PhD@talia_shirazi
25 Nov 2020
“Parity predicts biological age acceleration in post-menopausal, but not pre-menopausal, women” by ✋ @whastings2012 @asher_rosinger @CalenRyan is out in @SciReports today (rdcu.be/cbisw)! A small-ish 🧵 breaking down what we found: (1/n)
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Research in plants and animals generally supports this hypothesis, as do large epidemiological studies showing higher risk for some diseases and all-cause mortality, especially at the high end of fertility and among younger mothers. e.g. Zhang et al. 2016 nature.com/articles/srep1935…

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Evolutionary theory leads to the prediction that energy and resources allocated to reproduction should come at the expense of somatic maintenance, leading to faster biological aging. [Image courtesy of Dr. Amy Boddy]
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