Ph.D. student in the Marraffini lab @RockefellerUniv | Formerly @UCSF @UCBerkeley | NSF GRFP Fellow
Joined April 2019
- Tweets 48
- Following 252
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2 Photos and videos
Pinned Tweet
11 Apr 2023
It's up! Super excited to share our work highlighting the utility of 🔥phage accessory genes🔥 as a tool to elucidate the many layers of phage-host competition.
"If you want to know what the host is doing, just ask its virus" - Sukrit, probably
11 Apr 2023
Years ago, we wrote a proposal about using phage anti-defense genes to discover new defense systems. The idea was to take advantage of anti-defense gene clustering (islands) to ask what the neighbors of known anti-RM/CRISPR genes are inhibiting. 1/5
biorxiv.org/content/10.1101/…
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Héloïse Carion retweeted
5 May 2025
Grad student @CarionHeloise of the Marraffini lab was interviewed by @MolecularCell about her latest paper on the activation of bacterial programmed cell death by phage inhibitors of host immunity. Check it out here:
cell.com/molecular-cell/full…
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Héloïse Carion retweeted
26 Feb 2025
It is finally out!
Muntathar Al-Shimary, Doudna Lab, @bradyfcress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)!
Check out the final paper in @NatureMicrobiol
nature.com/articles/s41564-0…
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Héloïse Carion retweeted
28 Oct 2024
Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.1101/…
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Héloïse Carion retweeted
22 Aug 2024
Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: defensefinder.mdmlab.fr/. Read below for our insights into the >47K detectable systems📈 tiny.cc/8xrizz
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Héloïse Carion retweeted
3 Jul 2024
I am thrilled to start my lab as an assistant professor @biozentrum & @NCCR_AntiResist of @UniBasel_en this fall. I will continue my research interest in bacteria & jumbophage interactions. Equally thrilled to be closer to our families after 10 years.
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Héloïse Carion retweeted
18 Apr 2024
Excited to share my latest work from the @MarraffiniLab, in collaboration with @PhoebeARice, now online @Nature!!
nature.com/articles/s41586-0…
We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria!
A thread 🧵: 1/
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Héloïse Carion retweeted
29 Mar 2024
New preprint from the lab, led by outstanding student Claire Kokontis! (@CKokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one.
biorxiv.org/content/10.1101/…
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Héloïse Carion retweeted
1 Mar 2024
Hachiman is hot off the (preprint) presses! @owen_t_tuck and I in @doudna_lab present a model for how this broad-activity defense system recognizes genome integrity, a core feature of phage infection.
Check out the preprint and Owen's thread for the news:
1 Mar 2024
New preprint! @ben_a_adler and I @doudna_lab, in collaboration with @Emy_nim and @JoePogliano, unveil a mechanism for Hachiman immunity. The punchline - Hachiman is a genome integrity sensor. @UCB_Chemistry @igisci @HHMINEWS
biorxiv.org/content/10.1101/…
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Héloïse Carion retweeted
8 Dec 2023
Yesterday, i had the honor of becoming part of the first Scientific Council for the French President, among a group of 12 incredible scientists.
A tad far from my 🦠, but hopefully will help a bit in fostering the role of science & knowledge in our society and democracy.
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Héloïse Carion retweeted
19 Sep 2023
I’m really excited to share our new pre-print “Genome-wide Characterization of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi”, with co-first author Muntathar Al-Shimary @doudna_lab and the newly-minted @bradyfcress lab!
biorxiv.org/content/10.1101/…
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Héloïse Carion retweeted
14 Sep 2023
Happy to share our new preprint!
We used viperins🐍, to understand the conservation and diversification of immune genes across domains of life.
A deep dive in the evolutionary history of immune genes shared by prokaryotes and eukaryotes!
biorxiv.org/cgi/content/shor…
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Héloïse Carion retweeted
5 Sep 2023
Class picture time for incoming @RockefellerUniv grad student class!
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Héloïse Carion retweeted
12 May 2023
The increasing discovery of anti-phage bacterial immune systems (>100 in 5 years!) means an increasing diversity of phage activators. Here, @joeBondyDenomy and I review phage proteins as a prominent ‘pattern of pathogenesis’ and how they activate immunity. tinyurl.com/tmrpwrnk
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It's finally out! 🚀 Before doing a genome-wide screen in P. aeruginosa looking for immune systems, look in these two conserved anti-phage hotspots we named cDHS1 and cDHS2.
academic.oup.com/nar/advance…
Congrats to all the coauthors!
@joeBondyDenomy @ErinHuiting @ARDavidson_UofT
Excited to share an exciting discovery which I think will help us understand the anti-phage arsenal of bacteria!
biorxiv.org/content/10.1101/…
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Héloïse Carion retweeted
3 May 2023
BIG Congratulations to @Nicole_D_Marino who just signed her offer letter at UPenn @PennVet Pathobiology Departmant to start her own lab! The Marino lab opens Jan 1, 2024 focusing on new discoveries at the interface of phage and host immunity! s/o to Chair @BrodskyIgor
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Héloïse Carion retweeted
20 Apr 2023
If like me you like to analyse genomics data in Jupyter notebooks I have something for you:
dbikard.github.io/genomenote…
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Héloïse Carion retweeted
20 Feb 2023
Super thrilled to share our new publication led by @ben_a_adler “Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins” on single strand RNA Fiersviridae #phages nature.com/articles/s41589-0…
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6 Feb 2023
Erin is a ⭐️!! What a fun story
6 Feb 2023
Our latest CBASS story from the @joeBondyDenomy lab has arrived! 🙌Through a serendipitous collaboration with Yue Feng's lab, we uncovered an anti-CBASS protein that ‘sponges’ up a broad spectrum of cyclic dinucleotides.
cell.com/cell/fulltext/S0092…
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