Joined June 2012
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- Followers 3,159
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20 Photos and videos
The review Martin Howard and I wrote on “Graded versus ON/OFF control in quantitative gene expression and epigenetic memory” is now available at EMBO J doi 10.1038/s44318-026-00750-y
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Caroline Dean retweeted
21 Feb 2025
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
biorxiv.org/content/10.1101/…
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Caroline Dean retweeted
26 Jun 2024
In our new review paper, @ywan_wan and I focused on the functional importance of RNA structure in gene regulation. Many thanks to Yue and Xinang! I really enjoy the writing process. nature.com/articles/s41580-0…
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Caroline Dean retweeted
14 Jun 2024
We are hiring postdocs at @Cambridge_Uni
Join our diverse and inclusive team and help us understand chromatin phase transitions with multiscale simulations: jobs.cam.ac.uk/job/46962/
Friends please RT! Sorry if I've missed your posts, haven't been using X
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Caroline Dean retweeted
7 Jun 2024
NEWS - How transcription delivers epigenetic silencing
Two new studies reveal core principles of how chromatin and transcription interconnect to regulate gene expression @CarolineDeanLab
okt.to/3Hx5ID
okt.to/aV16XA
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7 Jun 2024
Check out the movie that summarises our papers out now in @MolecularCell youtube.com/watch?v=atLsplJ_…🧬🎞️
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Caroline Dean retweeted
And as back-to-back with this other modelling paper with my dear friend Govind Menon! From Martin Howard group AND @ReeSvenja @robertietswaart @Bobby_Mapes, among others @JohnInnesCentre, so for me is like having twins 😍
cell.com/molecular-cell/full…
I am thrilled beyond words to share with you all that our work, previously posted as @biorxivpreprint, is now out in @MolecularCell @CarolineDeanLab @JohnInnesCentre @Miguel_Montez_ @Bobby_Mapes @XiaofengFangLab @lapassmore @MRC_LMB @La_UPM @CBGP_Madrid
cell.com/molecular-cell/full…
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Caroline Dean retweeted
I am thrilled beyond words to share with you all that our work, previously posted as @biorxivpreprint, is now out in @MolecularCell @CarolineDeanLab @JohnInnesCentre @Miguel_Montez_ @Bobby_Mapes @XiaofengFangLab @lapassmore @MRC_LMB @La_UPM @CBGP_Madrid
cell.com/molecular-cell/full…
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Caroline Dean retweeted
10 Apr 2024
I'm glad to share that one of my projects in @CarolineDeanLab is now published on bioRxiv. Thanks to all authors! We have used several approaches to characterize FCA condensates in vivo.
8 Apr 2024
Modular structure of RNA 3' processing condensates involving the Arabidopsis RNA binding protein FCA biorxiv.org/cgi/content/shor… #bioRxiv
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Caroline Dean retweeted
Today we started a very special meeting at @JohnInnesCentre. The first reunion of all Dean alumni. First time I saw live so many people I read papers from! Good science and a lot of fun ahead! @CarolineDeanLab @YiliangDing
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Caroline Dean retweeted
5 Mar 2024
TOPICAL REVIEW: Flowering time: from physiology, through genetics to mechanism (Robert Maple, Pan Zhu, Jo Hepworth, Jia-Wei Wang, Caroline Dean) buff.ly/3uOf5NJ @Bobby_Mapes @PanZhu_WLU @joahepworth @CarolineDeanLab @ASPB #PlantSci
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19 Jan 2024
COOLAIR and PRC2 function in parallel to silence FLC during vernalization - out now! 🌱❄️Great effort by all the authors (on twt @_MathiasLN @emateobonmati @wolffsworld @shaolyyy)
18 Jan 2024
Our paper is officially out @PNASnews
We aimed to better understand the role of lncRNA and Polycomb during FLC silencing.
Elucidating their interplay required a combination of genetics, molecular biology, and, importantly, computational modelling. 👇
pnas.org/doi/10.1073/pnas.23…
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18 Dec 2023
After 4 years in the lab @ReeSvenja successfully defended her PhD on the spatio-temporal regulation of FLC last Friday! Pictured here with supervisor Martin Howard and @ReaLAntKour. Congratulations Dr. Svenja Reeck!!
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19 Jul 2023
Excited to share with you our recent work on how different gene expression modes are integrated at FLC
doi.org/10.7554/eLife.79743
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19 Jul 2023
Here is a cheat sheet for everyone who is not as familiar with the terms of digital and analog gene regulation as we are after over 10 year of joined group meetings with the Howard group 🧬💻🌱😀 @JohnInnesCentre
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19 Jul 2023
Massive effort by all the authors and collaborators
@ReaLAntKour @meschichi @ReeSvenja @scottbscience Govind Menon @zhao_yusheng @JohnFoz Terri Holmes Lihua Zhao Huamei Wang Matthew Hartley Stefanie Rosa and Martin Howard
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10 Jul 2023
Another step closer to understanding the complexity of FLC regulation by showing that antisense transcription and PRC2 repression function in parallel during vernalization ❄️
Happy to share our recent work led by @_MathiasLN 🧬🌱and Govind Menon 💻
biorxiv.org/content/10.1101/…
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7 Jul 2023
Today we submitted two exciting stories to bioRxiv:
Driven by @emateobonmati we show that "The CPSF phosphatase module links transcription termination to chromatin silencing" biorxiv.org/content/10.1101/…
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7 Jul 2023
In the second paper led by Govind Menon, we developed a mathematical model to capture the different feedback mechanisms between co-transcriptional 3′ processing and chromatin modifications determining the rate at which Polycomb repression is established
biorxiv.org/cgi/content/shor…
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7 Jul 2023
All of this would not have been possible without the endless efforts of all the authors @emateobonmati Govind Menon @XiaofengFang1 @Bobby_Mapes Marc Fiedler @lapassmore @ReeSvenja Zhe Wu and Robert Ietswaart in this fruitful collaboration with the Howard group @JohnInnesCentre
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