USA. A Mexican restaurant. We had not yet ordered anything, and the food was already arriving. Chips. Salsa. Unrequested. Free. I stopped the waiter. "We have not earned these." "They just come with the table, man." They come with the TABLE. In my land, hospitality is a debt. Every gift creates an obligation, weighed carefully, returned in the proper season with interest of feeling. Here, the gift arrives before you have even proven you can pay for dinner. This is not an appetizer. This is a declaration: we trust you. Eat. I ate with the gravity the moment deserved. And then — I must report this calmly — the basket emptied, and a new one appeared. "Did we…?" "Refill," the waiter said. "It's bottomless." Bottomless. They have wells of salsa. The supply lines of this nation are beyond anything my ancestors imagined. My friend warned me. "Don't fill up on chips, dude." Too late. I had accepted three baskets. Honor demanded each one be finished — an unfinished gift is an insult. By the time my actual food arrived, I was a ruined man. I was not hungry. I was not comfortable. I had been defeated by a courtesy. Generosity that arrives before the request cannot be repaid. It can only be survived. I know the rule now. I have made my peace with the basket. One basket. Two at the most. Who am I deceiving. There is no number of baskets I would refuse. The trust of a nation is in that salsa, and I intend to honor all of it.

The only actual way to cook perfect bacon is to push it around the pan like this like a retard on low heat, and it’s so funny because whenever someone sees me do this they get annoyed and tell me to leave it alone, like many of you will, but just watch, bitch. Just watch.

Dr Tro, who has a financial interest in keto, cites multiple studies showing keto helps epilepsy. Here's a list of treatments that help epilepsy that don't have other beneficial aspects on mental health or wellbeing: Surgical and device interventions * Temporal lobectomy * Hemispherectomy * Corpus callosotomy * Responsive neurostimulation * Deep brain stimulation (anterior thalamic nucleus) Anticonvulsants that are neutral-to-harmful for mood and cognition * Phenobarbital (sedation, depression, cognitive blunting, behavioral disinhibition in kids) * Topiramate (cognitive slowing, word-finding problems, depression. The "dopamax" reputation) * Levetiracetam (irritability, aggression, depression. "Keppra rage") * Vigabatrin (depression, psychosis, plus irreversible visual field loss) * Perampanel (black-box warning for hostility, aggression, psychiatric events) * Zonisamide (depression, cognitive impairment) * Phenytoin (cognitive effects, no mood benefit) * Tiagabine (depression, encephalopathy) * Felbamate (anxiety, insomnia, and aplastic anemia/hepatotoxicity for good measure) And, of course, the ketogenic diet itself, which has no positive randomized controlled trials in mental health.

SpaceX a clôturé son premier jour de cotation à 2 100 milliards de dollars, 19%. Tout le monde regarde le chiffre. Personne ne regarde ce qu'il price réellement. Laissez-moi vous dire ce que le marché vient d'acheter, et pourquoi je pense que cette boîte vaudra 30 à 50 trillions d'ici 5 ans. D'abord, le symbole. Cette IPO est un référendum. D'un côté, 20 ans de discours sur la décroissance, la sobriété, la redistribution, la fin de l'histoire gérée par des comités. De l'autre, un homme qui a dit "je vais rendre l'humanité multiplanétaire", que tout le monde a traité de clown, et qui vient de créer la plus grosse entreprise cotée de l'histoire en partant d'un entrepôt à El Segundo. Le marché a voté. Le wokisme avait des départements RH, SpaceX avait des fusées. Les fusées ont gagné. Ensuite, la mécanique économique, parce que c'est là que tout le monde se trompe. Les analystes valorisent SpaceX comme une entreprise de lancement plus Starlink. C'est comme valoriser Internet en 1995 sur le marché du fax. Starship ne réduit pas le coût du kilo en orbite de 20%, il le divise par 100. Et chaque fois dans l'histoire qu'un coût d'infrastructure est divisé par 100, ce n'est pas le marché existant qui grossit, ce sont des industries entières qui naissent. Le coût du calcul divisé par 100 a donné Internet, le smartphone, l'IA. Le coût de l'orbite divisé par 100 va donner une économie spatiale complète. Faisons la liste de ce qui devient rentable quand le kilo en orbite coûte le prix d'un billet d'avion. Les data centers orbitaux, avec énergie solaire continue et refroidissement gratuit, au moment exact où l'IA fait exploser la demande énergétique terrestre. La fabrication en microgravité de semi-conducteurs, de fibres optiques, d'organes imprimés impossibles à produire sous gravité. Le tourisme orbital de masse, puis les hôtels lunaires, qui passeront du fantasme au business plan exactement comme la croisière de luxe au 20ème siècle. Le transport point à point terrestre, Paris-Tokyo en 40 minutes. L'industrie minière des astéroïdes, dont un seul corps de classe M contient plus de métaux que tout ce que l'humanité a extrait depuis le néolithique. Et Mars en ligne de mire, pas comme destination touristique, mais comme le plus grand projet d'infrastructure jamais entrepris, avec tout ce que ça implique de demande en énergie, matériaux, robotique, IA. SpaceX ne participera pas à ces marchés. SpaceX possède le péage d'entrée de tous ces marchés. C'est AWS, mais pour la civilisation. Apple vaut 3 500 milliards en vendant des rectangles de verre sur une seule planète. Le premier monopole d'accès à une frontière infinie à 30 ou 50 trillions dans 5 ans, ce n'est pas de l'exubérance, c'est une simple règle de trois sur l'expansion du marché adressable. Et maintenant, la partie que je préfère. Ce futur n'a pas besoin de bureaucrates. Il n'y a pas de comité consultatif en orbite. Pas de commission Théodule sur Mars. Chaque dollar de cette nouvelle économie sera créé par des ingénieurs, des techniciens, des soudeurs, des pilotes, des entrepreneurs. Les diplômés en gestion de la norme vont devoir apprendre un métier utile, et franchement, c'est une excellente nouvelle pour eux aussi : construire est infiniment plus fun que contrôler. Parce que c'est ça, le vrai signal d'aujourd'hui. Pendant 50 ans on nous a vendu un futur rétréci : moins d'énergie, moins d'enfants, moins d'ambition, gérer le déclin proprement. Et là, d'un coup, le plus gros actif financier du monde est un pari sur l'abondance, l'expansion et l'aventure. Le pessimisme vient de passer en position vendeuse sur lui-même. Le futur sera méga fun. Il y aura des hôtels avec vue sur la Terre, des honeymoons en orbite, des gamins qui diront "papa, c'était comment avant les fusées réutilisables" comme on dit "c'était comment avant Internet". Et quelque part dans les années 2030, un humain marchera sur Mars en livestream devant 5 milliards de personnes, et ce jour-là plus personne ne se souviendra du nom d'un seul de ses détracteurs. Achetez de l'optimisme. C'est encore sous-valorisé.

Which PUFAs are bad? Oxidized PUFAs are bad. We need small amounts of essential fatty acids (EFAs). Cardiolipin in the inner mitochondrial membrane uses a lot of linoleic acid (LA), but too much in the diet can cause problems with inflammation and even collapsing the membrane. You may hear blanket statements about LA, but the situation is truly nuanced. LA according to textbooks becomes arachidonic acid (AA or ARA). It is necessary for inflammation signaling. Not everyone converts LA to ARA with any real efficiency. ARA is needed for molecules to physically contort to properly load triglycerides in the liver and get them loaded onto VLDL for export. It seems diabetics can have a functional deficiency of ARA trapped in fat cells and not enough in the liver which contributes to ectopic fat build up. It’s also needed in lipid rafts on cell membranes. It is an essential fat. It can be obtained by eating animal foods. LA and ARA are Ω6 fats. There’s also GLA and DGLA and CLA that are beneficial. CLA from ruminants helps reduce our belly fat when we consume it. It was a big deal years ago. I don’t hear much about it now. D/GLA is an anti inflammatory Ω 6. Not everyone converts this well. It’s actually in the middle between LA on its way to ARA. People with skin conditions, ADHD, and women with hormone issues often benefit from GLA which is found in evening primrose oil and borage oil. The other PUFAs are Ω 3. They are named after double bond positions, but I won’t get into that. I like to distinguish these as HUFA (highly unsaturated fatty acids) because most idiots blathering on about “PUFA bad” don’t have a clue about the chemistry. ALA is considered essential, though it seems mostly important for what it can be transformed into. There are a series of enzymes that desaturate and elongate fatty acids and dietary intake can create competition for binding. Genetics also influence how well these enzymes work. The demonizing of Ω 6 is really due to how our modern processed food diets have a huge imbalance in these fatty acids. Ω6 dominates in seed oils and contributes to runaway inflammation. Truth is we need some trace amounts of both Ω 3 and 6. The ratio between the two is important, and consuming too much 6 can cripple conversion of any trace 3s. So consuming preformed fats is more ideal. Fatty fish have Ω3 DHA and EPA which we need. DHA concentrates in the brain. I mentioned cardiolipin in mitochondria concentrating LA, well in the brain, it prefers to swap out some LA for more DHA. In the heart, Cardiolipin prefers a higher proportion of EPA. These Ω3s are also used as signally molecules especially for anti inflammatory effects, resolving what the other pathway signaled for. It really is a balance. In deficiency states the body will make mead acid for membrane fluidity. It can substitute structurally, but not for signaling, despite wishful thinking. So “non-bad PUFAs” are: Trace amounts, like 1% of dietary intake for LA Preformed GLA (I supplement because I am a poor converter) Arachidonic acid (ARA) in meat, dairy, and especially eggs (body builders supplement this for growth so not everyone is afraid of this underrated EFA) ALA (because they say so. I need to read up on this again with fresh eyes). It’s found in plants, but seems to need to be converted to EPA and DHA to be truly useful. EPA and DHA, the fish oils, which are better when combined with phospholipids (which I did not go into), but krill oil is structured this way. Eggs are also loaded with phospholipids and choline (a subject all its own really). “Bad PUFAs” are boiled soybean oil, oils fried at high heat, especially for extended periods of time, partially hydrogenated oils, and any amount that disrupts the balance with Ω3, taking the ratio way outside of the 1:1 - 1:4 range. Salad dressings and cooking oil, oil in bakery goods, oil in “protein drinks” for the elderly and infirm, and too many nuts can simply be too much Ω6.