We apply biochemistry, synthetic biology, and chemical biology to study how phase separation organizes the bacterial cytoplasm and how bacteria make decisions.
Joined August 2018
- Tweets 609
- Following 1,032
- Followers 808
- Likes 10,624
22 Photos and videos
Pinned Tweet
24 Aug 2023
Together with Michael Collins, @schraderlab, @DylanTomares, @iamvidyadhar we examined how the phase separation of BR-bodies is logically wired to the enzymatic functions of a key client - PNPase nature.com/articles/s41598-0…
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Childers Lab retweeted
Mar 30
Just out @J_A_C_S We show that short peptide-based assemblies can promote enantioselective carboligation!
#SystemsChem #suprachem #catalysis
Grateful to @ANRFIndia & @DBTIndia @iiserkol @dcsiiserkol pubs.acs.org/doi/10.1021/jac… Check out our latest works ddaslab.com
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Distinguished Professor David H. Waldeck has sadly passed away.
We send our condolences to his family along with the Faculty, Students and staff that knew and worked with him. Read more about Prof. Waldeck's life and work using this link: zurl.co/LHyuX
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Childers Lab retweeted
1 Nov 2025
A study by Harriet Ellis and @JoshMcquail revealing new roles for glutathione in the adaptive response to N starvation in E. coli. biorxiv.org/content/10.1101/…
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5 Oct 2025
As the planet gets hotter & drier, can we make proteins & organisms more resilient to desiccation stress? Together with @shaharsu @SyracuseU & @alexholehouse @washumedicine, we show in @CellSystemsCP a sequence grammar encoding tolerance to dehydration.
cell.com/cell-systems/abstra…
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Childers Lab retweeted
28 Jun 2025
Just presented for the first time today by April @ProteinSociety who received their young investigator award! #ProudPI #FriedLabNews.
Is Anfinsen’s Thermodynamic Hypothesis of protein folding true? We think PGK challenges it in a truly striking way.
biorxiv.org/content/10.1101/…
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24 May 2025
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share!
youtube.com/watch?v=8YhJM6zx…
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Childers Lab retweeted
7 Apr 2025
Congratulations to the recipients of our department's inaugural best paper awards! This round of awards recognizes outstanding papers published in Summer 2024. Read about their work at the links below: zurl.co/0sufX
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19 Sep 2024
Carnegie Mellon biologists have discovered the mechanism behind telomere elongation, which has implications for treating cancer.
cmu.edu/mcs/news-events/2024…
Want to learn more? Register for an upcoming talk by lead researcher Professor Huaying Zhang.
cmu.zoom.us/webinar/register…
ALT SUMO and DNA repair factors co-localize to telomeres in ALT cancer cells.
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17 Sep 2024
Many thanks to @APSPhysiology #TPhysMag for featuring us in this month's "Under the Microscope"... Was fun to do this interview! @pittkidneyctr
physiology.org/publications/…
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13 Sep 2024
Controlled Protein-Membrane Interactions Modulate Self-Organization of Min Protein Patterns (Katja Zieske and co-workers) @ZieskeLab @MPI_Light #openaccess onlinelibrary.wiley.com/doi/…
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Childers Lab retweeted
12 Sep 2024
1. Excited to share our new study, just published in Cell. First off, link to paper: cell.com/cell/fulltext/S0092…
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18 Aug 2024
🔬🦠 Read our latest review tinyurl.com/2y9ebsgl in @PLOSPathogens on bacterial condensates, their role in stress sensing and response, and potential for influencing host-pathogen interactions. Fun project with the @ChildersLab. Congrats to @moeka_sasazawa and @DylanTomares
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9 Jul 2024
Check out our latest paper in @nchembio, where we developed our CAGE split intein platform to study signaling events using proteomic profiling. This enables insights into the differential molecular connections of fusion oncogenes. Congrats to @GihoonLee1!
nature.com/articles/s41589-0…
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2 Jul 2024
So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of @AriSarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.1101/…) 1/12
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Childers Lab retweeted
15 Jun 2024
Membrane binding properties of the cytoskeletal protein bactofilin
We characterize the membrane-binding motif of bactofilin and investigate the interplay between membrane binding, polymerization and client-protein recruitment.
A great collaboration with the Schäfer lab (MD simulations) and Wieland Steinchen/@BangeBalcony (HDX analysis), led by former PhD student Ying Liu.
doi.org/10.1101/2024.06.14.5…
@SYNMIKRO @mpi_marburg @Bio_UMR
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12 Jun 2024
Published in #OpenBiology: Bacterial division ring stabilizing ZapA versus destabilizing SlmA modulate FtsZ switching between biomolecular condensates and polymers ow.ly/vxIG50SfkpL | #Biochemistry #Biophysics #SyntheticBiology
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11 Jun 2024
Excited to share my lab’s first preprint! We found that increasing DNA binding by type IV pili in an Acinetobacter pathogen can boost its natural transformation rates by ~100-fold, demonstrating that DNA binding is rate-limiting for natural transformation. biorxiv.org/content/10.1101/…
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Childers Lab retweeted
5 Jun 2024
Pick of the Week, out #OpenAccess in @ChemSystemsChem by @ChildersLab:
Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter-to-Life Transitions
ow.ly/kP6W50S9Vjo
SystemsChem Talents: ow.ly/opyk50S9Vs3
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Childers Lab retweeted
28 May 2024
Just online @NatureComms cationic peptide nanotubes can bind weak hydride transfer agents to facilitate efficient reduction of esters in water! Grateful to Swarnajayanti Grant, @serbonline , CSIR & @iiserkol rdcu.be/dJbwI #systemschem #enzymemimics
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25 May 2024
Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter-to-Life Transitions by W. Seth Childers and co-workers @ChildersLab #OpenAccess onlinelibrary.wiley.com/doi/…
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