The Chowdhury lab studies #DSBrepair, #RadiationOncology & #microRNAs as biomarkers @Harvardmed @DanaFarber @BrighamWomens. Account managed by lab members.
Joined August 2017
- Tweets 187
- Following 331
- Followers 1,742
- Likes 292
48 Photos and videos
Big congratulations to @SusanKilgas, who won a Poster Presentation Award at the 20th International p53 Workshop | p53 Conference, which took place last week in Toronto!
Fantastic work! #p53biology
2
5
23
711
Chowdhury Lab retweeted
Apr 16
New paper out today in @MolecularCell
We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.
Congratulations to first author Kaimeng Huang, all co-authors and collaborators.
sciencedirect.com/science/ar…
3
7
34
1,933
Apr 16
New paper out today in @MolecularCell
We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.
Congratulations to first author Kaimeng Huang, all co-authors and collaborators.
sciencedirect.com/science/ar…
3
7
34
1,933
Apr 16
Deletion of the MRE11 pPAS reduces MRN complex abundance and phenocopies hypomorphic MRE11 defects. We further find that loss of the pPAS triggers ectopic DNA replication and confluence‑induced cell death, revealing non‑canonical, non‑DDR functions linked to MRE11.
1
3
269
Apr 16
Finally, we demonstrate that PAS‑mediated promoter looping broadly regulates DDR gene expression and genome stability, expanding the conceptual framework for how DDR factors are controlled.
3
233
Chowdhury Lab retweeted
Mar 31
Excited to announce: EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning
Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research
Abstract deadline: 17 May: meetings.embo.org/event/26-d…
10
36
2,065
Mar 26
The Chowdhury Lab at the Dana-Farber Cancer Institute is hiring a Senior Research Technician!
If you are passionate about NGS and its applications in cancer research, apply here: careers.dana-farber.org/job/…
1
4
9
1,161
Mar 26
We are looking for a candidate with hands-on experience in NGS to drive workflows in fundamental genome stability research and clinical genomics. This role offers the opportunity to work on sequencing projects both within our lab and in collaboration with clinical teams.
1
284
Mar 20
Excited to share that Michelle Swift has been selected as an OCRA grantee! This support will help us study mechanisms of PARP inhibitor resistance in ovarian cancer and identify new therapeutic opportunities.
ocrahope.org/research/curren…
11
625
Mar 16
Congratulations to @ChiaraMasnovo on receiving the @AmericanCancer Postdoctoral Fellowship! 🎉 Her project will be defining the DNA Repair Independent Mitotic Role of 53BP1
Mentor: Dipanjan Chowdhury
Co-mentor: Alexander Spektor
Well deserved recognition of outstanding work! 👏
2
17
1,162
Mar 15
Congratulations to @SusanKilgas on receiving the first place Best Poster Award at the DNA Damage Mutation and Cancer Gordon Research Conference for her poster on a novel layer of p53 regulation through TIRR 🎉
1
4
27
1,556
Mar 11
Congratulations to Michelle Swift on receiving the Best Short Talk Award at the #DRRSC26 Fusion Conference for her presentation on BRCA1/BARD1 regulation of DNA repair. 🎉
@Fusion_Conf
13
629
Chowdhury Lab retweeted
2 Sep 2025
Excited to share our new paper from Sara J. Buhrlage lab & @ChowdhuryLab! We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 pathway loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
2
13
41
6,257
Chowdhury Lab retweeted
20 Aug 2025
🧬 Grad students and postdocs in DNA repair/DDR: don’t forget to register for the 2026 GRS “Safeguarding the Genome” seminar — Feb 28–Mar 1, Ventura, CA. Keynote: @ChowdhuryLab. Abstracts due by Nov 23, 2025. Register here: 🔗 grc.org/dna-damage-mutation-…
1
18
36
4,296
Chowdhury Lab retweeted
23 Jul 2025
📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-abst…
2
29
123
8,576
22 May 2025
Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/scie…
3
24
132
9,805
Chowdhury Lab retweeted
14 May 2025
Thank you to @ChowdhuryLab (@Harvardmed,
@DanaFarber) for joining us for a fantastic #WednedsayLectureSeries on "#DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab.
3
24
2,130
30 Oct 2024
📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context!
sciencedirect.com/science/ar…
2
20
107
10,759
3 Oct 2024
Enjoying New England fall weather with our annual lab hike! Celebrated recent achievements from the lab. Cheers to all of you 🍾
1
4
22
2,430