I did it! London Marathon 2025 done. ☑️🏃‍♀️🥇🙌🏻💜☀️ Thank you to everyone for your encouragement and donations to my chosen charity @PancreaticCanUK. Any last contributions to my fundraising page are greatly appreciated. 🔗 2025tcslondonmarathon.enthus… Congratulations to all runners!

Happy to share our latest study @Nature , where we evaluate somatic evolution and the effect of treatment in normal tissue using duplex sequencing 1/n nature.com/articles/s41586-0…

Just over 2 weeks to go until my @LondonMarathon run in aid of @PancreaticCanUK - Last long run was 21.8 miles 🏃‍♀️- Pancreatic cancer is a cause close to my ❤️ after the death of a friend - Any donations to my fundraising page are gratefully received 🙏🏻 - 2025tcslondonmarathon.enthus…

It’s been a long time coming…#PhDone

Huge congratulations @ZaccaSimo!! So utterly well deserved. Great news to round off a wonderfully successful year. Thank you for the inspiration and mentorship you are providing to so many of us who are setting out on our cancer research careers. 🌟

We are so grateful to @qianthefirst for this outstanding @NatureGenet News&Views piece highlighting our recent SPRINTER work and framing it so beautifully within the literature. A truly valuable resource! 🙏 Read it here👉 doi.org/10.1038/s41588-024-0… 🧵Dive into SPRINTER's work 👇

The human proteomic revolution proceeds with high-throughput assessment, AI analytics, correlation with health and disease, drug interactions, biomarkers cell.com/cell/fulltext/S0092…

Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in @Nature

Vamos, @RafaelNadal!   As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional.   Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I was stepping into your backyard, and you made me work harder than I ever thought I could just to hold my ground. You made me reimagine my game—even going so far as to change the size of my racquet head, hoping for any edge.   I’m not a very superstitious person, but you took it to the next level. Your whole process. All those rituals. Assembling your water bottles like toy soldiers in formation, fixing your hair, adjusting your underwear... All of it with the highest intensity. Secretly, I kind of loved the whole thing. Because it was so unique—it was so you.   And you know what, Rafa, you made me enjoy the game even more.    OK, maybe not at first. After the 2004 Australian Open, I achieved the #1 ranking for the first time. I thought I was on top of the world. And I was—until two months later, when you walked on the court in Miami in your red sleeveless shirt, showing off those biceps, and you beat me convincingly. All that buzz I’d been hearing about you—about this amazing young player from Mallorca, a generational talent, probably going to win a major someday—it wasn’t just hype.   We were both at the start of our journey and it’s one we ended up taking together. Twenty years later, Rafa, I have to say: What an incredible run you’ve had. Including 14 French Opens—historic! You made Spain proud... you made the whole tennis world proud.   I keep thinking about the memories we’ve shared. Promoting the sport together. Playing that match on half-grass, half-clay. Breaking the all-time attendance record by playing in front of more than 50,000 fans in Cape Town, South Africa. Always cracking each other up. Wearing each other out on the court and then, sometimes, almost literally having to hold each other up during trophy ceremonies.   I’m still grateful you invited me to Mallorca to help launch the Rafa Nadal Academy in 2016. Actually, I kind of invited myself. I knew you were too polite to insist on me being there, but I didn’t want to miss it. You have always been a role model for kids around the world, and Mirka and I are so glad that our children have all trained at your academies. They had a blast and learned so much—like thousands of other young players. Although I always worried my kids would come home playing tennis as lefties.   And then there was London—the Laver Cup in 2022. My final match. It meant everything to me that you were there by my side—not as my rival but as my doubles partner. Sharing the court with you that night, and sharing those tears, will forever be one of the most special moments of my career.   Rafa, I know you’re focused on the last stretch of your epic career. We will talk when it’s done. For now, I just want to congratulate your family and team, who all played a massive role in your success. And I want you to know that your old friend is always cheering for you, and will be cheering just as loud for everything you do next.   Rafa that!   Best always, your fan, 
 Roger

1/ This is the next chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord. 🧵nature.com/articles/s41586-0…

In our new paper just out in Science Advances we investigate mechanisms that may be limiting responses of KRAS mutant lung cancer to KRAS inhibitors and immunotherapy. science.org/doi/10.1126/scia…

science.org/doi/10.1126/scia… T cells receive regulatory signals from close neighbours, through ligand-receptor interactions and cytokines. Therefore we dived into the local neighbourhoods of CD8 T cells to investigate why a lung cancer model was resistant to KRAS-G12C-i a-PD1.

"Lung cancer is one of the hardest types of cancer to treat, so working out how to harness the immune system to better target tumours is so important." Read about the new work from Megan Cole, @JulianDownward, @F_vanMaldegem and more ⤵️ crick.ac.uk/news-and-reports…

Ready for #singlecellclub @ScienceLab_MCBI? 😀Excited to hear from @EgleKvedaraite (@karolinskainst) on human mononuclear phagocytes in tissue using #scRNAseq, #flowcytometry✨ & #imaging, and @ColliverEmma (@TheCrick) on the PHLEX computational toolkit for #singlecellimaging 🔬

Together with @CharlesSwanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…nature.com/articles/s41588-0…... 🧵below

Cancer research PhD opportunities with a talented and supportive group leader. 👇🏻 I had the pleasure of working with Alex during my PhD. Please share with your networks. 🧬

***Wet lab cancer research postdoc opportunity in the Swanton lab*** - crick.wd3.myworkdayjobs.com/… It has been a privilege to start my research career with this group and at the Crick.🧑‍🔬

This 600-year-old painting is one of the most mysterious in history. That mirror at the back is just 3 inches wide — yet it reflects the entire room in immense detail. Look closer at it and you'll realize nothing is as it seems… (thread) 🧵

Paris is truly a beautiful city!💜 These are 10 of the most beautiful competition venues at the Paris 2024 Olympics... 1. Grand Palais (Champs-Élysées) - to host Taekwondo & Fencing

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules