NEW ARTICLE: BERBERINE and CANCER - New promising research on this plant derived alkaloid
Used for thousands of years in Ancient Chinese Medicine as an anti-inflammatory, Berberine has been re-discovered recently for its anti-cancer properties
Plants produce numerous distinct natural products including secondary metabolites, such as terpenoids, phenolics, and alkaloids
Alkaloids have remarkable biological and pharmacological properties such as antimicrobial, antifungal, anti-inflammatory, antioxidant, antihypercholesterolemic, antidiabetic and anticancer
Berberine is an alkaloid derived from roots of various plants such as Berberis vulgaris, B. aristotle, B. aquifolium, Hydrastus canadensis, Pellodendron chenins, and Coptis rhizomes
Berberine is cytotoxic against the most aggressive breast cancers - triple negative breast cancer
Berberine also reverses resistance to chemotherapy (doxorubicin) in breast cancer.
In colon cancer, berberine increases apoptosis and inhibits invasion and metastasis of colorectal carcinoma cells
Animal studies in Pancreatic cancer show berberine reducing growth of tumors in mice by 70%
Animal studies also show decreases in tumor growth in glioblastoma, a very aggressive brain cancer
Berberine suppresses capacity of castration-resistant prostate cancer cells to spread and infiltrate (blocks metastasis)
These are some of the most aggressive cancers that Berberine shows significant activity against, through numerous mechanisms:
- apoptosis
- autophagy
- generating ROS
- decreasing NF-κB
- inhibiting matrix metalloproteinases gene expression
- cell cycle arrest
- suppresses migration and invasion of tumor cells
- regulates expression of microRNAs
- inhibits angiogenesis
- regulates telomerase activity
- upregulates p53 (!)
I review the positives and negatives of Berberine in the use of "alternative treatment approaches" to cancer
“Berberine has been shown to inhibit cell proliferation and angiogenesis through modulating cell cycle, cell apoptosis, cell autophagy, and the tumor microenvironment. This review emphasized that Berberine as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to achieve clinical application for cancer therapy.”
Much more in the article...
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