Excited to share our work on chromatin landscape remodeling in cloned embryos! 🐄🐄We started off w/ simple question: how does the somatic epigenome reprogram to prepare for the onset of transcription (EGA)? tinyurl.com/yc4wv76p

Two distinct causes contribute to the low efficiency of human pre-impl... sciencedirect.com/science/ar…

A grant cap tells scientists there is a limit to their discoveries. The entire capitalist critique of communism is literally that when you put ceilings on what people are allowed to aspire to, collective ambition shrinks, and innovation becomes less likely. I would really encourage people to do a quick RePORTER search for a few HHMI faculty or recipients of NIH Pioneer, Transformative Research R01, or Outstanding Investigator R35 awards, and look at how many NIH grants they had when they reached that level.

✨Rare model organisms can teach us how to build a body differently. In snail embryos blastomeres can be as big as the rest of the embryo! 🐌Phrontis vibex blastula stained for tubulin (gray), phalloidin (blue) and histone (magenta). 🔬 #ModelMonday #DevBio 📸: Clemens Cabernard

Fyodor, your critique matters. And so does the research to show the boundaries. In addition to promise, we show potential for base editor toxicity in human embryos: clearly not a green light. As you know, my lab did the same for Cas9 when a claim was published that it could correct a mutation, but instead removed chromosomes. Great promise without documented risk enables the very thing we want to prevent: a premature and uninformed run to the clinic. We saw it with Cas9. Thats why we do this work: data first. Thank you for the discussion.

New preprint: Base editing allows for efficient and highly specific editing and development of early human embryos. It avoids the genotoxic consequences of a DSB seen with Cas9. Some embryos are uniformly edited, yielding stem cells. This will change the discussion on heritable editing. Even so, there are previously unknown risks that we have also identified. It is not ready for application. Pls find here: biorxiv.org/content/10.64898…

it’s really inspiring to see the collective response of humanities professors on twitter whenever an academic says something positive about artificial intelligence. it feels like getting the whole gang together again for one last hurrah before turning off the lights for good.

We find that teaching or research experience is less helpful in administration than experience working in senior care or child care, preferably both.

We just decided to stop teaching everyone math, in the hopes that this would make society equal because everyone would be equally incompetent

To be clear, universities are doing this because they think it will enable professors to get 2x as many grants and teach 4x as many students for the same pay.

All the admins leaving for other jobs isn’t a sign that people are fleeing the college. It’s healthy turnover. Time for some new energy. Except for me, I am staying.

If you know how much Chicago (or any other university) is paying to give everyone on campus Claude Enterprise, my DMs are open. I am curious how this expense compares to the apparently “too expensive” humanities PhD programs Chicago has cut. I bet the answer is illuminating!

I love @DSHB_antibodies and we use their products all the time in the lab!

Decoding the origins of cellular self-organization for engineered biology go.nature.com/4e1m3Br

PhD committee trying to help a struggling student

We're so used to reagents being unreliable in biology that many people probably bought these antibodies, spent weeks troubleshooting them, and then marked them as "bad" without reporting back to Thermo... We just accept that you have to sift through multiple antibodies every time you design a new assay

New online! Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation dlvr.it/TSkDVT

Today in absurd grant review comments we have: Only studying females is a weakness…in a grant on endometriosis. 🤷‍♀️🤷‍♀️🤷‍♀️ Aren’t you all supposed to have a ton of education?!?

Pan, J., Li, Y., Lin, Z. et al. Spatiotemporal transcriptome atlas of human embryos after gastrulation. Nature (2026). doi.org/10.1038/s41586-026-1…

立花領域究代表による成果がNature Structural & Molecular Biology誌に掲載されました! Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation nature.com/articles/s41594-0…

A fertilized egg’s first few divisions rely on proteins stored in fibrous structures. The ordered nature of these structures and clues about their function are revealed. go.nature.com/4nNiHX6